Results 21 to 30 of about 6,757,592 (330)
Folding–unfolding asymmetry and a RetroFold computational algorithm
Royal Society Open Science, 2023 We treat protein folding as molecular self-assembly, while unfolding is viewed as disassembly. Fracture is typically a much faster process than self-assembly.
Sergey Shityakov +2 more
doaj +1 more source
The unfolded protein response [PDF]
Journal of Cell Science, 2003 The endoplasmic reticulum (ER) is a principal site for folding and maturation of transmembrane, secretory and ER-resident proteins. Perturbations that alter ER homeostasis can lead to accumulation of unfolded proteins (UPs), which is a threat to all living cells.
Chuan Yin, Liu, Randal J, Kaufman
openaire +2 more sources
As Simple As Possible, but Not Simpler: Exploring the Fidelity of Coarse-Grained Protein Models for Simulated Force Spectroscopy. [PDF]
PLoS Computational Biology, 2016 Mechanical unfolding of a single domain of loop-truncated superoxide dismutase protein has been simulated via force spectroscopy techniques with both all-atom (AA) models and several coarse-grained models having different levels of resolution: A Gō model
Mona Habibi +2 more
doaj +1 more source
Protein unfolding: Rigidity lost [PDF]
Proceedings of the National Academy of Sciences, 2002 We relate the unfolding of a protein to its loss of structural stability or rigidity. Rigidity and flexibility are well defined concepts in mathematics and physics, with a body of theorems and algorithms that have been applied successfully to materials, allowing the constraints in a network to be related to its deformability.
A J, Rader +3 more
openaire +2 more sources
How Quickly Do Proteins Fold and Unfold, and What Structural Parameters Correlate with These Values?
Biomolecules, 2020 The correlations between the logarithm of the unfolding rate of 108 proteins and their structural parameters were calculated. We showed that there is a good correlation between the logarithm of folding and unfolding rates (0.79) and protein stability and
Anna V. Glyakina, Oxana V. Galzitskaya
doaj +1 more source
MECHANICAL UNFOLDING OF DDFLN4 STUDIED BY COARSE-GRAINED KNOWLEDGE-BASED CABS MODEL
TASK Quarterly, 2014 Mechanical unfolding of the fourth domain of Distyostelium discoideum filamin (DDFLN4) was studied using a CABS – coarse-grained knowledge-based protein model.
MAKSIM KOUZA +4 more
doaj +1 more source
Exploring early stages of the chemical unfolding of proteins at the proteome scale. [PDF]
PLoS Computational Biology, 2013 After decades of using urea as denaturant, the kinetic role of this molecule in the unfolding process is still undefined: does urea actively induce protein unfolding or passively stabilize the unfolded state?
Michela Candotti +6 more
doaj +1 more source
The unfolded protein response [PDF]
Current Biology, 2005 Where does the UPR function? Between the endoplasmic reticulum (ER) and the nucleus of eukaryotic cells. All secreted proteins and proteins that reside in secretory compartments translocate as nascent peptide chains into the ER, where they may undergo folding, modification and assembly before assuming their functional conformations.
Chawla, Aditi, Niwa, Maho
openaire +2 more sources
Direction dependent mechanical unfolding and Green Fluorescent Protein as a force sensor [PDF]
, 2011 An Ising--like model of proteins is used to investigate the mechanical unfolding of the Green Fluorescent Protein along different directions. When the protein is pulled from its ends, we recover the major and minor unfolding pathways observed in ...
Caraglio, M. +2 more
core +2 more sources
Indonesian Journal of Chemistry, 2018 Molecular dynamics simulations of the B1 fragment of protein G (56 residues) have been performed at 325, 350, 375, 400, 450 and 500 K for 10 ns. An analysis of its structural and energetic parameters has indicated that the unfolding process of the GB1 ...
Tony Ibnu Sumaryada +2 more
doaj +1 more source