Results 121 to 130 of about 3,106,622 (403)

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Pharmacokinetics and Biochemical Efficacy of an α₁-Proteinase Inhibitor (Aralast NP) in α₁-Antitrypsin Deficiency: a Cross-Product Retrospective Comparability Analysis. [PDF]

Pulm Ther, 2022
Li Z, Franke RM, Morris DN, Yel L.
europepmc   +1 more source

Lung deposition of inhaled Alpha-1-proteinase inhibitor (Alpha1-PI) - problems and experience of Alpha1-PI inhalation therapy in patients with hereditary Alpha1-PI deficiency and cystic fibrosis [PDF]

, 2010
R. Siekmeier
openalex   +1 more source

Possible role of extracellularly released phagocytic proteinases in the coagulation disorder during liver transplantation [PDF]

, 1991
Orthotopic liver transplantation is frequently associated with a complex coagulation disorder, influencing the outcome of the procedure. In this respect, disseminated intravascular coagulation (DIC) had been suggested to be of causative importance for ...
Blumhardt, G., Himmelreich, G., Jochum, Marianne, Machleidt, W., Neuhaus, P., Riess, H., Roissaint, R.   +6 more
core  

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Investigating the Effects of a New Peptide, Derived from the Enterolobium contortisiliquum Proteinase Inhibitor (EcTI), on Inflammation, Remodeling, and Oxidative Stress in an Experimental Mouse Model of Asthma-Chronic Obstructive Pulmonary Disease Overlap (ACO). [PDF]

Int J Mol Sci, 2023
Barbosa JAS, da Silva LLS, João JMLG, de Campos EC, Fukuzaki S, Camargo LDN, Dos Santos TM, Dos Santos HT, Bezerra SKM, Saraiva-Romanholo BM, Lopes FDTQDS, Bonturi CR, Oliva MLV, Leick EA, Righetti RF, Tibério IFLC.   +15 more
europepmc   +1 more source

The proteinase yscB inhibitor (PBI2) gene of yeast and studies on the function of its protein product [PDF]

, 1991
Peter Schu, Paz Suárez‐Rendueles, Dieter H. Wolf   +2 more
openalex   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Corrigendum: Exploration of the Role of Serine Proteinase Inhibitor A3 in Alcohol Dependence Using Gene Expression Omnibus Database. [PDF]

Front Psychiatry, 2022
Zhang B, Wang G, Huang CB, Zhu JN, Xue Y, Hu J.   +5 more
europepmc   +1 more source

Survival and feeding avoidance of the eucalyptus defoliator Thyrinteina arnobia exposed to the proteinase inhibitor berenil [PDF]

, 2011
Jeanne Scardini Marinho‐Prado, André Luiz Lourenção, Júlia Assunção de Castro Oliveira, R. N. C. Guedes, M. G. A. Oliveira   +4 more
openalex   +1 more source