Journal of Pharmacological Sciences, 2008 We examined the mechanism of thrombin on proliferation of synovial fibroblasts obtained from rheumatoid arthritis (RA). Thrombin concentration-dependently induced proliferation of synovial fibroblasts. Proliferation in response to thrombin (10 U /ml) was
Ikue Furuhashi +3 more
doaj
A novel cysteine proteinase inhibitor from seeds of Enterolobium contortisiliquum and its effect on Callosobruchus maculatus larvae. [PDF]
Biochem Biophys Rep, 2021 Nunes NNS +4 more
europepmc +1 more source
Interaction of Human Sperm Acrosomal Proteinase with Human seminal Plasma Proteinase Inhibitors [PDF]
, 1973 Fink, Edwin +4 more
core +1 more source
PROTEINASES AND PROTEINASE INHIBITORS IN FERTILIZATION [PDF]
, 1976 Schleuning, W. D. +4 more
openaire +3 more sources
The E3 ubiquitin ligase, RNF219, suppresses CNOT6L expression to exhibit antiproliferative activity
FEBS Open Bio, EarlyView.We identified RNF219 as a CCR4‐NOT complex‐interacting E3 ubiquitin ligase that targets the CCR4‐NOT subunit CNOT6L for ubiquitination. RNF219 directly binds to the DUF3819 domain of CNOT1 through its putative α‐helix spanning amino acids 521–542. Our findings also suggest that antiproliferative activity of RNF219 is at least partially mediated by ...
Shou Soeda +9 more
wiley +1 more source
Obtaining of transgenic papaya plants var. Maradol roja that carry out the rice oryzacystatin gene
Biotecnología Vegetal, 2004 Papaya (Carica papaya L.), is severely affected by Papaya Ringspot virus, which belongs to plant potyvirus group. A recent strategy for pest control produced by this virus is the transformation with genes encoding cysteine proteinase inhibitors.
Milady F. Mendoza +6 more
doaj
The effects of secreted aspartyl proteinase inhibitor ritonavir on azoles-resistant strains of Candida albicans as well as regulatory role of SAP2 and ERG11. [PDF]
Immun Inflamm Dis, 2021 Feng W +6 more
europepmc +1 more source
GENETICALLY MODIFIED PLANTS EXPRESSING PROTEINASE INHIBITORS, SAPINA2A OR SAPIN2B, AND METHODS OF USE THEREOF FOR THE INHIBITION OF TRYPSIN-AND CHYMOTRYPSIN-LIKE ACTIVITIES [PDF]
, 2004 The present invention relates to proteinase inhibitor II genes, SaPIN2a and SaPIN2b, their production in transformed plants, and isolation of SaPIN2a and SaPIN2b proteins from transformed plants of the invention.
core
Isolation and characterization of human plasma α 1-proteinase inhibitor and a conformational study of its interaction with proteinases [PDF]
, 1976 Jeremy Saklatvala +2 more
openalex +1 more source
FEBS Open Bio, EarlyView.Papain‐like protease from SARS‐CoV‐2 plays an important role in the cleavage of the viral polyproteins and in the suppression of the host's immune response. Here, we present the results of an NMR screening study. We identified 86 binding compounds, of which five candidates were chosen for in‐depth analysis.
Dennis J. Pyper +5 more
wiley +1 more source