Activation of NF‐κB Signaling by Optogenetic Clustering of IKKα and β
Advanced Biology, EarlyView.This study presents an optogenetic approach for graded clustering of eGFP‐fused proteins using an eGFP‐specific nanobody and engineered Cryptochrome 2 variants. The method enables potent, reversible activation of NF‐κB signaling via endogenous pathways, as confirmed by RNA sequencing. This versatile system provides a spatially and temporally controlled
Alexandra Anna Maria Fischer +8 more
wiley +1 more source
Phagocyte proteinases in multiple trauma and sepsis [PDF]
, 1993 Fritz, Hans +4 more
core +1 more source
Effect of proteinase inhibitors on intracellular processing of cathepsin B, H and L in rat macrophages [PDF]
, 1988 Kenji Hara +2 more
openalex +1 more source
Advanced Biology, EarlyView.The regenerative potential of adipose tissue‐derived stem cells can be enhanced through chemical stimulation in vitro. A short stimulation protocol using forskolin, either alone or in combination with other growth factors, under xeno‐free conditions enhanced the pro‐angiogenic responses in human ASCs.
Maria Vittoria Giraudo +5 more
wiley +1 more source
Synthesis of the HIV-Proteinase Inhibitor Saquinavir: A Challenge for Process Research
CHIMIA, 1996 The task of process research, namely developing efficient, economically and technically as well as ecologically feasible syntheses in time, is demonstrated on the HIV-proteinase inhibitor Saquinavir, a complex molecule comprising six stereo ...
Wolfgang Göbring +5 more
doaj +2 more sources
Disturbances of selected plasma proteins in Hyperdynamic Septic Shock [PDF]
, 1982 A Ledgerwood +38 more
core +1 more source
Serine proteinases and their inhibitors in Phycomyces blakesleeanus.
, 1979 Eckhard Fischer, Klaus-Sten Thomson
openalex +1 more source
Effects of microbial proteinase inhibitors on the degradation of endogenous and internalized proteins by rat yolk sacs [PDF]
, 1981 S E Knowles +3 more
openalex +1 more source
LIN28B Promotes Cancer Cell Dissemination and Angiogenesis
Advanced Biology, EarlyView.Children diagnosed with high‐risk neuroblastoma have a 5‐year event‐free survival rate of less than 50% and poor outcomes after recurrence. Deregulation of the LIN28B oncogene can be addressed in these patients. Upregulation of LIN28B is shown to support the metastatic cascade.
Diana Corallo +8 more
wiley +1 more source
Proteolysis-induced pathomechanisms in acute inflammation and related therapeutic approaches [PDF]
, 1991 A Billing +30 more
core +1 more source