Results 191 to 200 of about 3,106,622 (403)

Down‐regulation of Shh in the hair follicles of mice during chemotherapy‐induced hair loss is mediated by the JAK/STAT1 signaling pathway

FEBS Open Bio, EarlyView.
We found that during chemotherapy‐induced alopecia (CIA), Sonic hedgehog (Shh) expression significantly decreased in hair follicle Shh+ cells, whereas the Janus‐activated kinase/signal transducer and activator of transcription 1 (JAK/STAT1) signaling pathway was markedly activated.
Ruifang Fan, Jingling Huang, Xiang Lin, Tingjiao Lan, Yuli Tang, Ling Sun, Guixuan Zhou   +6 more
wiley   +1 more source

Insight into blood proteinase-inhibitor system and pathogenesis of renal tuberculosis induced by phylogenomically different Mycobacterium tuberculosis strains in rabbit model. [PDF]

BMC Nephrol
Esmedlyaeva D, Mokrousov I, Alekseeva N, Blum N, Dyakova M, Dogonadze M, Vyazovaya A, Polev D, Ariel B, Vinogradova T, Yablonsky P.   +10 more
europepmc   +1 more source

Auxin Levels Regulate the Expression of a Wound-Inducible Proteinase Inhibitor II-Chloramphenicol Acetyl Transferase Gene Fusion in Vitro and in Vivo.

Plant Physiology, 1989
A. Kernan, R. Thornburg
semanticscholar   +1 more source

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Effects of a Proteinase Inhibitor from <i>Inga laurina</i> Seeds (ILTI) on <i>Aedes aegypti</i> Larval Development. [PDF]

J Xenobiot
Jacobowski A, Leite W, Júnior AM, Reis E, Pires L, Silva V, Rocha L, Arruda E, Franco O, Cardoso M, Hiane P, Macedo M.   +11 more
europepmc   +1 more source

Proteinases and proteinase inhibitors in ejaculates of men with adnex affections [PDF]

, 1985
Brunner, H., Fink, Edwin, Friesen, A., Hofstetter, A., Jochum, Marianne, Krause, W., Rothauge, C. F., Schießler, Hans, Schill, W.-B., Weidner, W.   +9 more
core  

In vitro phosphorylation of plant plasma membrane proteins in response to the proteinase inhibitor inducing factor.

Proceedings of the National Academy of Sciences of the United States of America, 1989
E. Farmer, G. Pearce, C. Ryan
semanticscholar   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Clinical Study Support by Long-Term Stability Studies of Alpha₁-Proteinase Inhibitor and Urea in Relevant Biological Matrices. [PDF]

Pharmaceuticals (Basel)
Engelmaier A, Zimmermann M, Butterweck HA, Weber A.   +3 more
europepmc   +1 more source