Results 331 to 340 of about 3,106,622 (403)
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British Medical Bulletin, 1995
The primary agents responsible for cartilage and bone destruction in joint diseases are active proteinases degrading collagen and proteoglycan. All four main classes of proteolytic enzymes are involved in either the normal turnover of connective tissue or its pathological destruction.
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The primary agents responsible for cartilage and bone destruction in joint diseases are active proteinases degrading collagen and proteoglycan. All four main classes of proteolytic enzymes are involved in either the normal turnover of connective tissue or its pathological destruction.
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Proteinase inhibitors in Ascarida
Parasitology Today, 1994Ascaris suum and A. lumbricoides are intestinal parasites that survive in a hostile hydrolytic environment They contain low-molecular-weight proteins that can inactivate most of the proteinases present in the worm's surroundings. Jeffrey Hawley, Mark Martzen and Robert Peanasky suggest that host specificity of these nematodes may be associated with the
J H, Hawley, M R, Martzen, R J, Peanasky
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Proteinases and Proteinase Inhibitors
1992The peritoneal cavity is well endowed with proteinases both in the parietal and viseral peritoneum as well as in the peritoneal fluid. Proteinases have a major role in activating and modulating the complement, coagulation, kinin, fibrinolytic, and extracellular matrix remodeling systems, and thus are critical components of the peritoneal response to ...
Gere S. diZerega, Kathleen E. Rodgers
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Invertebrate proteinase inhibitors
Pure and Applied Chemistry, 1994Abstract
R.-A. Boigegrain +3 more
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International Journal of Peptide and Protein Research, 1979
Investigations have been carried out on the complex formed between sorghum Inhibitor III and α‐chymotrypsin by physico‐chemical methods. An apparent dissociation constant (Ki) of 4.0 times 10‐8 M has been calculated for the complex. This enzyme‐inhibitor complex was isolated by gel filtration on Sephadex G‐75 and a molecular weight of 48,000 was ...
Kumar, Harish PM +2 more
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Investigations have been carried out on the complex formed between sorghum Inhibitor III and α‐chymotrypsin by physico‐chemical methods. An apparent dissociation constant (Ki) of 4.0 times 10‐8 M has been calculated for the complex. This enzyme‐inhibitor complex was isolated by gel filtration on Sephadex G‐75 and a molecular weight of 48,000 was ...
Kumar, Harish PM +2 more
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Acrosomal Proteinase and Proteinase Inhibitor of Human Spermatozoa
Science, 1972The acrosomal proteinase of human spermatozoa was characterized and differs from other human proteinases. The enzyme has optimal activity at p H 8.0, is inactive below p H 5.0 or above p H 10.5, requires calcium for maximum activity, hydrolyzes fibrinogen, gelatin, and
L J, Zaneveld +2 more
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?1-Proteinase inhibitor and mucus proteinase inhibitor in human lung emphysema
The Clinical Investigator, 1992The role of the antiproteases alpha 1-proteinase inhibitor (alpha 1PI) and mucus proteinase inhibitor (MPI) in human lung emphysema was investigated by measuring their amount and functional activity against trypsin, leukocyte elastase, and pancreatic elastase in the bronchoalveolar lavage fluid (BALF).
G, Trefz +4 more
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Proteinase inhibitors as antileishmanial agents
Transactions of the Royal Society of Tropical Medicine and Hygiene, 1982Leishmania mexicana mexicana amastigote proteinase activity was largely inhibited by low concentrations of leupeptin, antipain and two epoxysuccinates, compounds known to affect cysteine proteinases. Of these inhibitors, only two had leishmanicidal activity. trans-Dicyclohexylepoxysuccinate at 10 microgram/ml inhibited the in vitro transformation of L.
G H, Coombs, D T, Hart, J, Capaldo
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1980
Reports of myelin basic protein (MBP) fragments [2,11] and raised proteolytic activity [8] in the cerebrospinal fluid (CSF) of multiple sclerosis (MS) patients in exacerbation are indicative of inflammatory demyelination. Basic protein is highly susceptible to digestion by the neutral proteinases of polymorphonuclear leucocytes (PMNL) and macrophages ...
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Reports of myelin basic protein (MBP) fragments [2,11] and raised proteolytic activity [8] in the cerebrospinal fluid (CSF) of multiple sclerosis (MS) patients in exacerbation are indicative of inflammatory demyelination. Basic protein is highly susceptible to digestion by the neutral proteinases of polymorphonuclear leucocytes (PMNL) and macrophages ...
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