Results 91 to 100 of about 3,477,167 (351)

Wound-induced proteinase inhibitors from tomato leaves. II. The cDNA-deduced primary structure of pre-inhibitor II.

Journal of Biological Chemistry, 1985
A cDNA containing the complete amino acid-coding region of wound-induced tomato Inhibitor II was constructed in the plasmid pUC9. The open reading frame codes for 148 amino acids including a 25-amino acid signal sequence preceding the N-terminal lysine ...
J. Graham, G. Pearce, J. Merryweather, K. Titani, L. Ericsson, C. Ryan   +5 more
semanticscholar   +1 more source

Neonatal microglia and proteinase inhibitors-treated adult microglia improve traumatic brain injury in rats by resolving the neuroinflammation. [PDF]

Bioeng Transl Med, 2022
Zheng P, Bai Q, Feng J, Zhao B, Duan J, Zhao L, Liu N, Ren D, Zou S, Chen W, Chen W.   +10 more
europepmc   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Rapid enzymatic test for phenotypic HIV protease drug resistance [PDF]

, 2003
A phenotypic resistance test based on recombinant expression of the active HIV protease in E. coli from patient blood samples was developed. The protease is purified in a rapid onestep procedure as active enzyme and tested for inhibition by five selected
Machleidt, Werner, Hoffmann, D., Assfalg-Machleidt, Irmgard, Helm, K. von der, Nitschko, H., Koszinowski, U.   +5 more
core   +1 more source

Discovery of juglone and its derivatives as potent SARS-CoV-2 main proteinase inhibitors. [PDF]

Eur J Med Chem, 2021
Cui J, Jia J.
europepmc   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Digestive enzymes of vine weevil (Otiorhynchus sulcatus) as potential targets for insect control strategies. [PDF]

, 2002
Over the previous quarter century the vine weevil (Otiorhynchus sulcatus) has become a pest of horticultural and agricultural plants. The vine weevil is a polyphagous coleopteran insect and is able to attack over one hundred different plant species.
Edwards, M.G., Edwards, Martin Gethin
core  

Osteoclastogenesis is decreased by cysteine proteinase inhibitors

, 2004
The effects of cystatin C and other cysteine proteinase inhibitors on osteoclast formation and differentiation have been investigated. Cystatin C decreased osteoclast formation stimulated by parathyroid hormone (PTH), 1,25(OH)(2)-vitamin D3 or ...
Kasprzykowski, F, Lerner, Ulf,, Lie, A, Grubb, Anders, Grubb, Anders,, Lie, Anita, Abrahamson, M, Kasprzykowska, Regina, Kasprzykowski, Franciszek, Lerner, Ulf H,, Grubb, A, Ransjo, M, Ransjö, Maria,, Abrahamson, Magnus, Lie, Anita,, Kasprzykowska, R, Brage, Monica, Ransjö, Maria, Lerner, UH, Lund University., Brage, M, Abrahamson, Magnus,   +21 more
core   +1 more source

Serine proteinase inhibitors from nematodes and the arms race between host and pathogen [PDF]

, 2001
Parasite nematode genomics is a relatively new field9, but already two of the most interesting gene families to be found encode serine proteinase inhibitors. This article describes a family of nematode proteinase inhibitors with homology to mammalian
Rick M Maizels, Xingxing Zang, Maizels, Rick, Zang, Xingxing   +3 more
core   +1 more source

Inhibition of Helicoverpa armigera gut pro-proteinase activation in response to synthetic protease inhibitors [PDF]

, 2012
Protease inhibitors play an important role in host plant defence against herbivores. However, insects have the ability to elevate the production of proteinases or resort to production of a diverse array of proteinases to offset the effect of proteinase ...
Kachole, M S, Sharma, H C, Parde, Vinod Dadarao   +2 more
core   +1 more source