Results 121 to 130 of about 734,343 (302)
Molecular Oncology, EarlyView.Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez +5 more
wiley +1 more source
Obtaining of transgenic papaya plants var. Maradol roja that carry out the rice oryzacystatin gene
Biotecnología Vegetal, 2004 Papaya (Carica papaya L.), is severely affected by Papaya Ringspot virus, which belongs to plant potyvirus group. A recent strategy for pest control produced by this virus is the transformation with genes encoding cysteine proteinase inhibitors.
Milady F. Mendoza +6 more
doaj
In Silico Comparison of Main Proteinase Inhibitors for Different Coronaviruses
مجلة بغداد للعلومCoronaviruses are enclosed positive stranded RNA viruses with spike protein protrusions that permit the virus to penetrate and affect host cells. The emergence of Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) and Middle East Respiratory ...
Tahani W. Jihad +3 more
doaj +1 more source
Molecular Oncology, EarlyView.This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault +12 more
wiley +1 more source
Proteinase inhibitor candidates for therapy of enzyme-inhibitor imbalances [PDF]
, 1992 Collins, John +6 more
core +1 more source
Interaction of Human Sperm Acrosomal Proteinase with Human seminal Plasma Proteinase Inhibitors [PDF]
, 1973 Zaneveld, L. J. D. +4 more
core +1 more source
Molecular Oncology, EarlyView.Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu +9 more
wiley +1 more source
Serine proteinase inhibitors isolated from boar seminal plasma
, 2002 Serine proteinase inhibitors were found in boar seminal plasma. The work was concentrated on isolation and characterization of proteinase inhibitors and study of the existence of inhibitors in complexes with other proteins in seminal ...
Jelínková, Petra
core
Hydroxyquinones are competitive non-peptide inhibitors of HIV-1 proteinase
, 1995 Quinones with one, two and three aromatic rings are a new class of micomolar non-peptidic inhibitors of HIV-1 proteinase, an enzyme essential for replication of Human Immunodeficiency Virus and an important drug target for AIDS.
Brinkworth R.I., Fairlie D.P.
core +1 more source
Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source