Results 51 to 60 of about 3,477,167 (351)

Digestive duet: midgut digestive proteinases of Manduca sexta ingesting Nicotiana attenuata with manipulated trypsin proteinase inhibitor expression.

PLoS ONE, 2008
BackgroundThe defensive effect of endogenous trypsin proteinase inhibitors (NaTPIs) on the herbivore Manduca sexta was demonstrated by genetically altering NaTPI production in M. sexta's host plant, Nicotiana attenuata.
Jorge A Zavala, Ashok P Giri, Maarten A Jongsma, Ian T Baldwin   +3 more
doaj   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Developments in plant breeding for improved nutritional quality of soya beans II. Anti-nutritional factors [PDF]

, 2000
Nutritional value of most plant materials is limited by the presence of numerous naturally occurring compounds which interfere with nutrient digestion and absorption.
Clarke, E, J. WISEMAN, E. J. CLARKE, Wiseman, J   +3 more
core   +1 more source

Development of an in vitro cleavage assay system to examine vaccinia virus I7L cysteine proteinase activity

Virology Journal, 2005
Through the use of transient expression assays and directed genetics, the vaccinia virus (VV) I7L gene product has been implicated as the major maturational proteinase required for viral core protein cleavage to occur during virion assembly.
Hruby Dennis E, Byrd Chelsea M
doaj   +1 more source

Comparison of three methods for concentration of rotavirus from artificially spiked shellfish samples [PDF]

Veterinary World, 2014
Background: Shellfish are a nutritious food source whose consumption and commercial value have risen dramatically worldwide. Shellfish being filter feeders concentrate particulate matters including microorganisms such as pathogenic bacteria and viruses ...
Vysakh Mohan, Shriya Rawat, K. M. Lokesh, H. V. Mohan, D. Avinash Reddy, Ashok Kumar , K N. Bhilegaonkar   +6 more
doaj   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

A neutron laue diffraction study of endothiapepsin: Implications for the aspartic proteinase mechanism [PDF]

, 2001
Current proposals for the catalytic mechanism of aspartic proteinases are largely based on X-ray structures of bound oligopeptide inhibitors possessing nonhydrolyzable analogues of the scissile peptide bond.
Myles, D. A. A., Erskine, P. T., Wood, S. P., L. Coates, Erskine, P.T., Wood, S.P., P. T. Erskine, Cooper, J. B., D. A. A. Myles, Coates, L., S. P. Wood, J. B. Cooper, Cooper, J.B., Myles, D.A.A.   +13 more
core   +1 more source

A novel in vitro cell model of the proteinase/antiproteinase balance observed in alpha-1 antitrypsin deficiency

Frontiers in Pharmacology
Background: Alpha-1 antitrypsin deficiency (AATD) is a genetic condition resulting from mutations in the alpha-1 antitrypsin (AAT) protein, a major systemic antiproteinase, resulting in reduced/no release of AAT, disrupting the proteinase/antiproteinase ...
Celine H. Chen, Helena Crisford, Aaron Scott, Aaron Scott, Elizabeth Sapey, Elizabeth Sapey, Elizabeth Sapey, Robert A. Stockley, Robert A. Stockley   +8 more
doaj   +1 more source

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

FEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

Isolation of six cysteine proteinase inhibitors from human urine. Their physicochemical and enzyme kinetic properties and concentrations in biological fluids.

Journal of Biological Chemistry, 1986
Six cysteine proteinase inhibitors were isolated from human urine by affinity chromatography on insolubilized carboxymethylpapain followed by ion-exchange chromatography and immunosorption.
M. Abrahamson, G. Salvesen, A. Barrett, A. Grubb   +3 more
semanticscholar   +1 more source