Results 31 to 40 of about 3,477,167 (351)

Antiviral proteinase inhibitors of plant and animal origin

Iberoamerican Journal of Medicine, 2020
Introduction: Over the past 10 years, much attention has been paid to the development of new antiviral drugs based on the suppression of the proteolytic activity of enzymes by trypsin inhibitors of plant and animal origin.
Valentina Divocha, Irina Komarevzeva
doaj   +1 more source

A KLK4 proteinase substrate capture approach to antagonize PAR1

Scientific Reports, 2021
Proteinase-activated receptor-1 (PAR1), triggered by thrombin and other serine proteinases such as tissue kallikrein-4 (KLK4), is a key driver of inflammation, tumor invasiveness and tumor metastasis.
Eitan Rabinovitch, Koishiro Mihara, Amiram Sananes, Marianna Zaretsky, Michael Heyne, Julia Shifman, Amir Aharoni, Morley D. Hollenberg, Niv Papo   +8 more
doaj   +1 more source

Inhibition of Plant-Pathogenic Fungi by the Barley Cystatin Hv-CPI (Gene Icy) Is Not Associated with Its Cysteine-Proteinase Inhibitory Properties

Molecular Plant-Microbe Interactions, 2003
The recombinant barley cystatin Hv-CPI inhibited the growth of three phytopathogenic fungi (Botrytis cinerea, Colletotrichum graminicola, and Plectosphaerella cucumerina) and the saprotrophic fungus Trichoderma viride.
M. Martínez, E. López-Solanilla, P. Rodríguez-Palenzuela, P. Carbonero, I. Díaz   +4 more
doaj   +1 more source

Characteristics of intracellular peptidase and proteinase activities from the mycelium of a cord-forming wood decay fungus Serpula lacrymans [PDF]

, 2001
Serpula lacrymans is a basidiomycete cord-forming wood decay fungus which reallocates nitrogen within an extensive perennial mycelial system in response to spatial discontinuities in external nutrient supply.
Burton, Kerry S., Watkinson, Sarah C., Wood, David A.   +2 more
core   +1 more source

Cystatins as calpain inhibitors: Engineered chicken cystatin- and stefin B-kininogen domain 2 hybrids support a cystatin-like mode of interaction with the catalytic subunit of μ-calpain [PDF]

, 2001
Within the cystatin superfamily, only kininogen domain 2 (KD2) is able to inhibit μ- and m-calpain. In an attempt to elucidate the structural requirements of cystatins for calpain inhibition, we constructed recombinant hybrids of human stefin B (an ...
Gross, Stefan, Machleidt, Werner, Assfalg-Machleidt, Irmgard, Pfeiler, Dietmar, Gabrijelcic-Geiger, Dusica, Gollmitzer, Nicole, García Diaz, Beatriz, Auerswald, Ennes A., Stubbs, Milton T., Fritz, Hans   +9 more
core   +1 more source

Molecular mechanisms of antithrombin-heparin regulation of blood clotting proteinases. a paradigm for understanding proteinase regulation by serpin family protein proteinase inhibitors

Biochimie, 2010
Serpin family protein proteinase inhibitors regulate the activity of serine and cysteine proteinases by a novel conformational trapping mechanism that may itself be regulated by cofactors to provide a finely-tuned time and location-dependent control of ...
S. Olson, B. Richard, G. Izaguirre, Sophia Schedin‐Weiss, P. Gettins   +4 more
semanticscholar   +1 more source

Insect digestive enzymes as a target for pest control [PDF]

Invertebrate Survival Journal, 2011
The continual need to increase food production necessitates the development and application of novel biotechnologies to enable the provision of improved crop varieties in a timely and cost-effective way.
M L Rodrigues Macedo, M das Graças Machado Freire   +1 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Novel bi- and trifunctional inhibitors of tumor-associated proteolytic systems [PDF]

, 2003
Serine proteases, cysteine proteases, and matrix metalloproteinases (MMPs) are involved in cancer cell invasion and metastasis. Recently, a recombinant bifunctional inhibitor (chCysuPA(19-31)) directed against cysteine proteases and the urokinasetype ...
Sato, Sumito, Assfalg-Machleidt, Irmgard, Magdolen, Ulla, Schmitt, Manfred, Rettenberger, Peter, Magdolen, Viktor, Krol, Janna   +6 more
core   +1 more source

Investigating Polypharmacology Through Targeting Known Human Neutrophil Elastase Inhibitors to Proteinase 3

, 2023
Using a combination of state-of-the-art free energy computational approaches together with in vitro IC50 assays, we evaluated the polypharmacological potential of a scaffold currently in clinical trials for inhibition of human neutrophil elastase (HNE ...
Fahimeh, Khorsand, Luis F, Cervantes, Ruth, Brenk, Juha Ilmari, Vahokovski, Nathalie, Reuter, Parveen, Gartan, Charles L., Brooks, Pushpak, Mizar, Bengt Erik, Haug   +8 more
core   +1 more source