Results 1 to 10 of about 10,718,710 (345)
Synthesized Anti-HER2 Trastuzumab-MCC-DM1 Conjugate: An Evaluation of Efficacy and Cytotoxicity [PDF]
Iranian Journal of Immunology, 2023 Background: Trastuzumab is a humanized monoclonal antibody that targets site-specifically human epidermal growth factor-2 receptor (HER2) cell surface antigen overexpressed in approximately 20% of human breast carcinomas. Despite its positive therapeutic
Soodabeh Shafiee +5 more
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Anti-cancer therapeutic strategies based on HGF/MET, EpCAM, and tumor-stromal cross talk
Cancer Cell International, 2022 As an intelligent disease, tumors apply several pathways to evade the immune system. It can use alternative routes to bypass intracellular signaling pathways, such as nuclear factor-κB (NF-κB), Wnt, and mitogen-activated protein (MAP)/phosphoinositide 3 ...
Khadijeh Barzaman +9 more
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Proteins, proteins everywhere [PDF]
Science, 2021 The first protein structures were determined by x-ray crystallography in 1957 by John C. Kendrew and Max F. Perutz. As a bioinorganic chemist, I was delighted that the structures were myoglobin and hemoglobin, both heme proteins with big, beautiful iron atoms.
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Nature Communications, 2021 ATTR amyloidosis causes heart failure through the accumulation of misfolded transthyretin in cardiac muscle. Here the authors report a mouse model of ATTR amyloidosis and demonstrate the involvement of protease activity in ATTR amyloid deposition.
Ivana Slamova +18 more
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Contextualized Protein-Protein Interactions [PDF]
Patterns, 2021 Protein-protein interaction (PPI) databases are an important bioinformatics resource, yet existing literature-curated databases usually represent cell-type-agnostic interactions, which is at variance with our understanding that protein dynamics are context specific and highly dependent on their environment.
Anthony Federico, Stefano Monti
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MUC1 is a potential target to overcome trastuzumab resistance in breast cancer therapy
Cancer Cell International, 2022 Although resistance is its major obstacle in cancer therapy, trastuzumab is the most successful agent in treating epidermal growth factor receptor 2 positive (HER2 +) breast cancer (BC).
Aysooda Hosseinzadeh +4 more
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Journal of Biological Engineering, 2021 Development of engineered non-pathogenic bacteria, capable of expressing anti-cancer proteins under tumor-specific conditions, is an ideal approach for selectively eradicating proliferating cancer cells.
Mitra Samadi +9 more
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Advances in Nutrition, 2011 Proteins are polymers of amino acids linked via α-peptide bonds. They can be represented as primary, secondary, tertiary, and even quaternary structures, but from a nutritional viewpoint only the primary (amino acid) sequence is of interest. Similarly, although there are many compounds in the body that can be chemically defined as amino acids, we are ...
Malcolm, Watford, Guoyao, Wu
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Design and characterization of a protein fold switching network
Nature Communications, 2023 In this work the authors investigate the structure-sequence dependance. The ability to design and characterize proteins at interfaces between three common folds suggests that fold switching is an intrinsic feature of protein folding language and likely ...
Biao Ruan +11 more
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Comparison of mucin-1 in human breast cancer and canine mammary gland tumor: a review study
Cancer Cell International, 2022 Mucin-1 (MUC-1) is a transmembrane glycoprotein, which bears many similarities between dogs and humans. Since the existence of animal models is essential to understand the significant factors involved in breast cancer mechanisms, canine mammary tumors ...
Rana Vafaei +6 more
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