Results 161 to 170 of about 13,117,352 (339)

TRPM8 levels determine tumor vulnerability to channel agonists

Molecular Oncology, EarlyView.
TRPM8 is a Ca2+ permissive channel. Regardless of the amount of its transcript, high levels of TRPM8 protein mark different tumors, including prostate, breast, colorectal, and lung carcinomas. Targeting TRPM8 with channel agonists stimulates inward calcium currents followed by emptying of cytosolic Ca2+ stores in cancer cells.
Alessandro Alaimo, Francesco Giuseppe Carbone, Kristi Buzo, Nicole Annesi, Sacha Genovesi, Annalisa Lorenzato, Karen Widmann, Michela Libergoli, Elisa Marmocchi, Giovanni Bertalot, Alberto Brolese, Mauro Giulio Papotti, Luca Molinaro, Orazio Caffo, Mattia Barbareschi, Alberto Bardelli, Alessandro Romanel, Sabrina Arena, Andrea Lunardi   +18 more
wiley   +1 more source

Harnessing subtractive genomics for drug target identification in Streptococcus agalactiae serotype v (atcc baa-611 / 2603 v/r) strain: An in-silico approach. [PDF]

PLoS One
Chowdhury ARK, Tithi FY, Bhuiyan NZ, Ishita AF, Sohel MMH.   +4 more
europepmc   +1 more source

THE BASAL METABOLISM AND THE SPECIFIC DYNAMIC ACTION OF PROTEIN IN LIVER DISEASE [PDF]

, 1921
Joseph C. Aub
openalex   +1 more source

Structure, Function, and Evolution of Coronavirus Spike Proteins.

Annual Review of Virology, 2016
Fang Li
semanticscholar   +1 more source

The anticancer effect of the HDAC inhibitor belinostat is enhanced by inhibitors of Bcl‐xL or Mcl‐1 in ovarian cancer

Molecular Oncology, EarlyView.
The pan‐HDAC inhibitor belinostat increases the expression of the pro‐apoptotic proteins Bim, Puma, and Noxa and induces apoptosis in ovarian cancer cell lines and patient‐derived tumor organoids when used at high concentrations. Moreover, inhibiting the anti‐apoptotic proteins Bcl‐xL or Mcl‐1 sensitizes these preclinical models to the cytotoxic effect
Cécilia Thomine, Sterenn Guillemot, Louis‐Bastien Weiswald, Romane Florent, Edwige Abeilard, Florence Giffard, Emilie Brotin, Mélanie Briand, Enora Dolivet, Laurent Poulain, Marie Villedieu   +10 more
wiley   +1 more source

Structural disorder and distinctive motifs in the C-terminal region of the MADS-domain transcription factors are conserved across diverse taxa. [PDF]

PLoS One
Ramírez-Aguirre E, Nava-Ramírez TB, Covarrubias AA, Garay-Arroyo A.   +3 more
europepmc   +1 more source

The effect of variations in protein and salt intake on the nitrogen and chloride content of sweat [PDF]

, 1934
D. P. Cuthbertson, W Guthrie
openalex   +1 more source

Protein-protein recognition

Progress in Biophysics and Molecular Biology, 1995
openaire   +3 more sources

Systematic profiling of cancer‐fibroblast interactions reveals drug combinations in ovarian cancer

Molecular Oncology, EarlyView.
Fibroblasts, cells in the tumor environment, support ovarian cancer cell growth and alter morphology and drug response. We used fibroblast and cancer cell co‐culture models to test 528 drugs and discovered new drugs for combination treatment. We showed that adding Vorinostat or Birinapant to standard chemotherapy may improve drug response, suggesting ...
Greta Gudoityte, Osheen Sharma, Laura Leuenberger, Emelie Wallin, Josefin Fernebro, Päivi Östling, Rebecka Bergström, Johan Lindberg, Ulrika Joneborg, Olli Kallioniemi, Brinton Seashore‐Ludlow   +10 more
wiley   +1 more source

Circulating proteins associated with histological subtypes of lung cancer from genetic and population-based perspectives. [PDF]

PLoS Genet
Lyu Z, Si G, Xing M, Li W, Gao X, Wang M, Song F, Chen K.   +7 more
europepmc   +1 more source