Results 1 to 10 of about 22,091 (247)
The enigma of the near-symmetry of proteins: Domain swapping. [PDF]
PLoS ONE, 2017 The majority of proteins form oligomers which have rotational symmetry. Literature has suggested many functional advantages that the symmetric packing offers. Yet, despite these advantages, the vast majority of protein oligomers are only nearly symmetric.
Maayan Bonjack-Shterengartz, David Avnir
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GRB2 dimerization mediated by SH2 domain-swapping is critical for T cell signaling and cytokine production [PDF]
Scientific Reports, 2023 GRB2 is an adaptor protein required for facilitating cytoplasmic signaling complexes from a wide array of binding partners. GRB2 has been reported to exist in either a monomeric or dimeric state in crystal and solution.
Aline Sandouk +8 more
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Domain swapping: a mathematical model for quantitative assessment of structural effects [PDF]
FEBS Open BioThe domain‐swapping mechanism involves the exchange of structural elements within a secondary or supersecondary structure between two (or more) proteins.
Irena Roterman +3 more
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Bioinformatics and Biology Insights, 2010 3-dimensional domain swapping is a mechanism where two or more protein molecules form higher order oligomers by exchanging identical or similar subunits. Recently, this phenomenon has received much attention in the context of prions and neurodegenerative
Khader Shameer +5 more
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Energetic Calculations to Decipher pH-Dependent Oligomerization and Domain Swapping of Proteins. [PDF]
PLoS ONE, 2015 Domain swapping mechanism is a specialised mode of oligomerization of proteins in which part of a protein is exchanged in a non-covalent manner between constituent subunits. This mechanism is highly affected by several physiological conditions.
Prashant Shingate +2 more
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Domain swapping in allosteric modulation of DNA specificity.
PLoS Biology, 2010 SgrAI is a type IIF restriction endonuclease that cuts an unusually long recognition sequence and exhibits allosteric self-modulation of cleavage activity and sequence specificity.
Chad K Park +7 more
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A five-residue motif for the design of domain swapping in proteins [PDF]
Nature Communications, 2019 Designing interfaces that can induce protein-protein interactions is a challenging problem. Here the authors show that a five amino acid sequence known to mediate domain swapping in cystatins can drive oligomerization when grafted onto functionally and ...
Neha Nandwani +6 more
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Domain swapping of complementarity-determining region in nanobodies produced by Pichia pastoris [PDF]
AMB Express, 2019 Easy preparation of chimeric nanobodies with various scaffolds is important for customizing abilities of nanobodies toward practical utilization. To accomplish high-throughput production of various nanobodies, utilization of microbes is an attractive ...
Natsuko Miura +7 more
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Amino‐acid composition after loop deletion drives domain swapping [PDF]
Protein Science, 2017 Ranabir Das +2 more
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3D domain swapping: As domains continue to swap [PDF]
Protein Science, 2002 Abstract Three‐dimensional (3D) domain swapping creates a bond between two or more protein molecules as they exchange their identical domains. Since the term '3D domain swapping' was first used to describe the dimeric structure of diphtheria toxin, the database of domain‐swapped proteins has greatly expanded. Analyses of the now about
Yanshun, Liu, David, Eisenberg
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