The enigma of the near-symmetry of proteins: Domain swapping. [PDF]
PLoS ONE, 2017 The majority of proteins form oligomers which have rotational symmetry. Literature has suggested many functional advantages that the symmetric packing offers. Yet, despite these advantages, the vast majority of protein oligomers are only nearly symmetric.
Maayan Bonjack-Shterengartz, David Avnir
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GRB2 dimerization mediated by SH2 domain-swapping is critical for T cell signaling and cytokine production [PDF]
Scientific Reports, 2023 GRB2 is an adaptor protein required for facilitating cytoplasmic signaling complexes from a wide array of binding partners. GRB2 has been reported to exist in either a monomeric or dimeric state in crystal and solution.
Aline Sandouk +8 more
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Domain swapping: a mathematical model for quantitative assessment of structural effects [PDF]
FEBS Open BioThe domain‐swapping mechanism involves the exchange of structural elements within a secondary or supersecondary structure between two (or more) proteins.
Irena Roterman +3 more
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Domain swapping in allosteric modulation of DNA specificity.
PLoS Biology, 2010 SgrAI is a type IIF restriction endonuclease that cuts an unusually long recognition sequence and exhibits allosteric self-modulation of cleavage activity and sequence specificity.
Chad K Park +7 more
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A five-residue motif for the design of domain swapping in proteins [PDF]
Nature Communications, 2019 Designing interfaces that can induce protein-protein interactions is a challenging problem. Here the authors show that a five amino acid sequence known to mediate domain swapping in cystatins can drive oligomerization when grafted onto functionally and ...
Neha Nandwani +6 more
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Domain swapping of complementarity-determining region in nanobodies produced by Pichia pastoris [PDF]
AMB Express, 2019 Easy preparation of chimeric nanobodies with various scaffolds is important for customizing abilities of nanobodies toward practical utilization. To accomplish high-throughput production of various nanobodies, utilization of microbes is an attractive ...
Natsuko Miura +7 more
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Evidences for the unfolding mechanism of three‐dimensional domain swapping [PDF]
Protein Science, 2013 AbstractThe full or partial unfolding of proteins is widely believed to play an essential role in three‐dimensional domain swapping. However, there is little research that has rigorously evaluated the association between domain swapping and protein folding/unfolding.
Zhirong Liu, Yongqi Huang
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Regulation of Dishevelled DEP domain swapping by conserved phosphorylation sites [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2021 Trevor Rutherford +2 more
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Environment-Dependent Dimerization as a Functional Switch in Leech Cystatin CysHv [PDF]
ToxinsCystatins from hematophagous organisms modulate host proteases and are promising biotechnological tools. CysHv, a secreted cystatin from the Brazilian leech Haementeria vizottoi, was previously characterized as a potent inhibitor of papain and cathepsin ...
Melissa Regina Fessel +2 more
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Amino‐acid composition after loop deletion drives domain swapping [PDF]
Protein Science, 2017 Ranabir Das +2 more
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