Results 41 to 50 of about 23,361 (277)
Retrotransposon Domain Swapping [PDF]
The Plant Cell, 2010 Whether you consider them major genomic parasites or potentially major drivers of genome expansion, long terminal repeat (LTR) retrotransposons are major, making up 15 to 90% of plant nuclear genomes (reviewed in Sabot and Schulman, 2006). These elements transpose by a replicate-and-paste mechanism, wherein an RNA copy of the retrotransposon is reverse
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Trimeric domain-swapped barnase
Proceedings of the National Academy of Sciences, 1999 The structure of a trimeric domain-swapped form of barnase (EC 3.1.27.3 ) was determined by x-ray crystallography at a resolution of 2.2 Å from crystals of space group R 32. Residues 1–36 of one molecule associate with residues 41–110 from another molecule related through threefold symmetry ...
Zegers, Nathalie +2 more
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Domain-swapping of mesophilic xylanase with hyper-thermophilic glucanase
BMC Biotechnology, 2012 Background Domain fusion is limited at enzyme one terminus. The issue was explored by swapping a mesophilic Aspergillus niger GH11 xylanase (Xyn) with a hyper-thermophilic Thermotoga maritima glucanase (Glu) to construct two chimeras, Xyn-Glu and Glu-Xyn,
Liu Liangwei +5 more
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PLoS Neglected Tropical Diseases, 2022 Trans-sialidases (TS) represent a multi-gene family of unusual enzymes, which catalyse the transfer of terminal sialic acids (Sia) from sialoglycoconjugates to terminal galactose or N-acetylgalactosamine residues of oligosaccharides without the ...
Mario Waespy +6 more
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Molecular Therapy: Methods & Clinical Development, 2022 Recent clinical successes have intensified interest in using adeno-associated virus (AAV) vectors for therapeutic gene delivery. The liver is a key clinical target, given its critical physiological functions and involvement in a wide range of genetic ...
Marti Cabanes-Creus +14 more
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The domain swapping of human cystatin C induced by synchrotron radiation. [PDF]
Sci Rep, 2019 Domain swapping is observed for many proteins with flexible conformations. This phenomenon is often associated with the development of conformational diseases.
Taube M +6 more
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Computational Studies of the Reversible Domain Swapping of p13suc1 [PDF]
Biophysical Journal, 2005 A minimalist representation of protein structures using a Go-like potential for interactions is implemented to investigate the mechanisms of the domain swapping of p13suc1, a protein that exists in two native conformations: a monomer and a domain-swapped dimer formed by the exchange of a beta-strand.
Chahine, J., Cheung, M. S.
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Genome-Wide Analysis of Domain-Swap Predicted Products in the Genome of Anti-Stress Medicinal Plant:
Bioinformatics and Biology Insights, 2019 Computational approaches to high-throughput data are gaining importance because of explosion of sequences in the post-genomic era. This explosion of sequence data creates a huge gap among the domains of sequence structure and function, since the ...
Atul Kumar Upadhyay +1 more
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The Making of a Slicer: Activation of Human Argonaute-1
Cell Reports, 2013 Argonautes are the central protein component in small RNA silencing pathways. Of the four human Argonautes (hAgo1–hAgo4) only hAgo2 is an active slicer.
Christopher R. Faehnle +4 more
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Linking in domain-swapped protein dimers
Scientific Reports, 2016 AbstractThe presence of knots has been observed in a small fraction of single-domain proteins and related to their thermodynamic and kinetic properties. The exchanging of identical structural elements, typical of domain-swapped proteins, makes such dimers suitable candidates to validate the possibility that mutual entanglement between chains may play a
Marco Baiesi +3 more
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