Results 31 to 40 of about 22,091 (247)
The Unfolding Story of Three-Dimensional Domain Swapping [PDF]
Structure, 2003 Three-dimensional domain swapping is the event by which a monomer exchanges part of its structure with identical monomers to form an oligomer where each subunit has a similar structure to the monomer. The accumulating number of observations of this phenomenon in crystal structures has prompted speculation as to its biological relevance. Domain swapping
Rousseau, Frederic +2 more
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Molecular Therapy: Methods & Clinical Development, 2022 Recent clinical successes have intensified interest in using adeno-associated virus (AAV) vectors for therapeutic gene delivery. The liver is a key clinical target, given its critical physiological functions and involvement in a wide range of genetic ...
Marti Cabanes-Creus +14 more
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Genome-Wide Analysis of Domain-Swap Predicted Products in the Genome of Anti-Stress Medicinal Plant:
Bioinformatics and Biology Insights, 2019 Computational approaches to high-throughput data are gaining importance because of explosion of sequences in the post-genomic era. This explosion of sequence data creates a huge gap among the domains of sequence structure and function, since the ...
Atul Kumar Upadhyay +1 more
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The Making of a Slicer: Activation of Human Argonaute-1
Cell Reports, 2013 Argonautes are the central protein component in small RNA silencing pathways. Of the four human Argonautes (hAgo1–hAgo4) only hAgo2 is an active slicer.
Christopher R. Faehnle +4 more
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Computational Studies of the Reversible Domain Swapping of p13suc1 [PDF]
Biophysical Journal, 2005 A minimalist representation of protein structures using a Go-like potential for interactions is implemented to investigate the mechanisms of the domain swapping of p13suc1, a protein that exists in two native conformations: a monomer and a domain-swapped dimer formed by the exchange of a beta-strand.
Chahine, J., Cheung, M. S.
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Domain swapping and amyloid fibril conformation [PDF]
Prion, 2012 For several different proteins an apparent correlation has been observed between the propensity for dimerization by domain-swapping and the ability to aggregate into amyloid-like fibrils. Examples include the disease-related proteins β 2-microglobulin and transthyretin.
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Linking in domain-swapped protein dimers
Scientific Reports, 2016 AbstractThe presence of knots has been observed in a small fraction of single-domain proteins and related to their thermodynamic and kinetic properties. The exchanging of identical structural elements, typical of domain-swapped proteins, makes such dimers suitable candidates to validate the possibility that mutual entanglement between chains may play a
Marco Baiesi +3 more
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Deciphering MCR-2 Colistin Resistance
mBio, 2017 Antibiotic resistance is a prevalent problem in public health worldwide. In general, the carbapenem β-lactam antibiotics are considered a final resort against lethal infections by multidrug-resistant bacteria.
Jian Sun +11 more
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Frontiers in Microbiology, 2014 The polymerase chain reaction (PCR) is widely applied across the biosciences, with archaeal Family-B DNA polymerases being preferred, due to their high thermostability and fidelity.
Ashraf eElshawadfy +5 more
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Structural Insights into RNA Dimerization: Motifs, Interfaces and Functions
Molecules, 2020 In comparison with the pervasive use of protein dimers and multimers in all domains of life, functional RNA oligomers have so far rarely been observed in nature.
Charles Bou-Nader, Jinwei Zhang
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