Results 31 to 40 of about 23,361 (277)
Unraveling the Functional Significance of Unstructured Regions in G Protein-Coupled Receptors
Biomolecules, 2023 Unstructured regions in functional proteins have gained attention in recent years due to advancements in informatics tools and biophysical methods.
Roberto Maggio +5 more
doaj +1 more source
Domain swapping is a consequence of minimal frustration [PDF]
Proceedings of the National Academy of Sciences, 2004 The same energy landscape principles associated with the folding of proteins into their monomeric conformations should also describe how these proteins oligomerize into domain-swapped conformations. We tested this hypothesis by using a simplified model for the epidermal growth factor receptor pathway substrate 8 src homology 3 domain protein, both of ...
Sichun, Yang +6 more
openaire +2 more sources
Frontiers in Microbiology, 2021 As the incidence of antibiotic-resistant bacteria has become increased, phage endolysins are believed as one of the promising alternatives to antibiotics.
Bokyung Son +7 more
doaj +1 more source
Three-Dimensional Domain Swapping Changes the Folding Mechanism of the Forkhead Domain of FoxP1. [PDF]
Biophys J, 2016 The forkhead family of transcription factors (Fox) controls gene transcription during key processes such as regulation of metabolism, embryogenesis, and immunity.
Medina E +6 more
europepmc +2 more sources
Dramatic structural changes resulting from the loss of a crucial hydrogen bond in the hinge region involved in C-terminal helix swapping in SurE: a survival protein from Salmonella typhimurium. [PDF]
PLoS ONE, 2013 Domain swapping is an interesting feature of some oligomeric proteins in which each protomer of the oligomer provides an identical surface for exclusive interaction with a segment or domain belonging to another protomer.
Yamuna Kalyani Mathiharan +3 more
doaj +1 more source
REC protein family expansion by the emergence of a new signaling pathway
mBio, 2023 This report presents multi-genome evidence that REC protein family expansion occurs when the emergence of new pathways gives rise to functional discordance.
Megan E. Garber +9 more
doaj +1 more source
Frontiers in Microbiology, 2021 Cotton is a commercial crop of global importance. The major threat challenging the productivity in cotton has been the lepidopteron insect pest Helicoverpa armigera or cotton bollworm which voraciously feeds on various plant parts.
Kesiraju Karthik +4 more
doaj +1 more source
IUCrJ, 2020 Protein dimerization or oligomerization resulting from swapping part of the protein between neighboring polypeptide chains is known to play a key role in the regulation of protein function and in the formation of protein aggregates.
Kitaik Lee +12 more
doaj +1 more source
Structure and stability of recombinant bovine odorant-binding protein: I. Design and analysis of monomeric mutants [PDF]
PeerJ, 2016 Bovine odorant-binding protein (bOBP) differs from other lipocalins by lacking the conserved disulfide bond and for being able to form the domain-swapped dimers.
Olga V. Stepanenko +5 more
doaj +2 more sources
Synthetic and Systems Biotechnology, 2020 Modular polyketide synthases (PKSs) are a multidomain megasynthase class of biosynthetic enzymes that have great promise for the development of new compounds, from new pharmaceuticals to high value commodity and specialty chemicals.
Erin E. Drufva +2 more
doaj +1 more source