Results 11 to 20 of about 23,361 (277)
Domain swapping: a mathematical model for quantitative assessment of structural effects [PDF]
FEBS Open BioThe domain‐swapping mechanism involves the exchange of structural elements within a secondary or supersecondary structure between two (or more) proteins.
Irena Roterman +3 more
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Bioinformatics and Biology Insights, 2010 3-dimensional domain swapping is a mechanism where two or more protein molecules form higher order oligomers by exchanging identical or similar subunits. Recently, this phenomenon has received much attention in the context of prions and neurodegenerative
Khader Shameer +5 more
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The enigma of the near-symmetry of proteins: Domain swapping. [PDF]
PLoS ONE, 2017 The majority of proteins form oligomers which have rotational symmetry. Literature has suggested many functional advantages that the symmetric packing offers. Yet, despite these advantages, the vast majority of protein oligomers are only nearly symmetric.
Maayan Bonjack-Shterengartz, David Avnir
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GRB2 dimerization mediated by SH2 domain-swapping is critical for T cell signaling and cytokine production [PDF]
Scientific Reports, 2023 GRB2 is an adaptor protein required for facilitating cytoplasmic signaling complexes from a wide array of binding partners. GRB2 has been reported to exist in either a monomeric or dimeric state in crystal and solution.
Aline Sandouk +8 more
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Domain-swapped dimer of Pseudomonas aeruginosa cytochrome c551: structural insights into domain swapping of cytochrome c family proteins. [PDF]
PLoS ONE, 2015 Cytochrome c (cyt c) family proteins, such as horse cyt c, Pseudomonas aeruginosa cytochrome c551 (PA cyt c551), and Hydrogenobacter thermophilus cytochrome c552 (HT cyt c552), have been used as model proteins to study the relationship between the ...
Satoshi Nagao +7 more
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Deposition Diseases and 3D Domain Swapping [PDF]
Structure, 2006 Protein aggregation is a feature of both normal cellular assemblies and pathological protein depositions. Although the limited order of aggregates has often impeded their structural characterization, 3D domain swapping has been implicated in the formation of several protein aggregates.
Bennett, Melanie J. +2 more
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Topological Determinants of Protein Domain Swapping [PDF]
Structure, 2006 Protein domain swapping has been repeatedly observed in a variety of proteins and is believed to result from destabilization due to mutations or changes in environment. Based on results from our studies and others, we propose that structures of the domain-swapped proteins are mainly determined by their native topologies. We performed molecular dynamics
Ding, Feng +3 more
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The Unfolding Story of Three-Dimensional Domain Swapping [PDF]
Structure, 2003 Three-dimensional domain swapping is the event by which a monomer exchanges part of its structure with identical monomers to form an oligomer where each subunit has a similar structure to the monomer. The accumulating number of observations of this phenomenon in crystal structures has prompted speculation as to its biological relevance. Domain swapping
Rousseau, Frederic +2 more
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Domain swapping and amyloid fibril conformation [PDF]
Prion, 2012 For several different proteins an apparent correlation has been observed between the propensity for dimerization by domain-swapping and the ability to aggregate into amyloid-like fibrils. Examples include the disease-related proteins β 2-microglobulin and transthyretin.
Van Der Wel, PCA
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Energetic Calculations to Decipher pH-Dependent Oligomerization and Domain Swapping of Proteins. [PDF]
PLoS ONE, 2015 Domain swapping mechanism is a specialised mode of oligomerization of proteins in which part of a protein is exchanged in a non-covalent manner between constituent subunits. This mechanism is highly affected by several physiological conditions.
Prashant Shingate +2 more
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