Results 1 to 10 of about 220,710 (308)
KRAS Dimerization Impacts MEK Inhibitor Sensitivity and Oncogenic Activity of Mutant KRAS
Cell, 2018 Marzia Capelletti +2 more
exaly +2 more sources
Molecular Approaches to Protein Dimerization: Opportunities for Supramolecular Chemistry
Frontiers in Chemistry, 2022 Protein dimerization plays a key role in many biological processes. Most cellular events such as enzyme activation, transcriptional cofactor recruitment, signal transduction, and even pathogenic pathways are significantly regulated via protein-protein ...
Dung Thanh Dang
doaj +1 more source
An essential Noc3p dimerization cycle mediates ORC double-hexamer formation in replication licensing
Life Science Alliance, 2023 Differential mutants confirmed Noc3’s separate roles in DNA replication and ribosome biogenesis, and an essential Noc3 dimerization cycle was found to mediate ORC dimerization in replication licensing.
Aftab Amin +8 more
doaj +1 more source
Inhibition of 5'-UTR RNA conformational switching in HIV-1 using antisense PNAs. [PDF]
PLoS ONE, 2012 BACKGROUND: The genome of retroviruses, including HIV-1, is packaged as two homologous (+) strand RNA molecules, noncovalently associated close to their 5'-end in a region called dimer linkage structure (DLS).
Braham Parkash +5 more
doaj +1 more source
Photo-Crosslinked Coumarin-Containing Bis-Urea Amphiphile Hydrogels
Gels, 2022 The design of photo-responsive supramolecular hydrogels based on coumarin dimerization and de-dimerization is described. The photo-responsive coumarin unit is chemically incorporated into an oligo(ethylene glycol) (OEG) bis-urea amphiphile that is ...
Jie Liu +4 more
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Revival of superconductivity in a one-dimensional dimerized diamond lattice
Scientific Reports, 2023 We study an s-wave superconductivity in a one-dimensional dimerized diamond lattice in the presence of spin–orbit coupling and Zeeman field. The considered diamond lattice, comprising of three sublattices per unitcell and having flat band, has two ...
Sanaz Shahbazi, Mir Vahid Hosseini
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EGFR trafficking: effect of dimerization, dynamics, and mutation
Frontiers in Oncology, 2023 Spontaneous dimerization of EGF receptors (EGFR) and dysregulation of EGFR signaling has been associated with the development of different cancers. Under normal physiological conditions and to maintain homeostatic cell growth, once EGFR signaling occurs,
Destiny F. Schultz +3 more
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Contextual computation by competitive protein dimerization networks [PDF]
CellMichael B Elowitz +2 more
exaly +2 more sources
Scientific Reports, 2021 Clostridium botulinum neurotoxin serotype A (BoNT/A) is a potent neurotoxin that serves as an effective therapeutic for several neuromuscular disorders via induction of temporary muscular paralysis.
Nicholas G. James +7 more
doaj +1 more source
ACS Combinatorial Science, 2020 A new coronavirus (CoV) caused a pandemic named COVID-19, which has become a global health care emergency in the present time. The virus is referred to as SARS-CoV-2 (severe acute respiratory syndrome-coronavirus-2) and has a genome similar (∼82%) to ...
Bhupesh Goyal, Deepti Goyal
semanticscholar +1 more source