Results 41 to 50 of about 197,285 (307)

A Single Conserved Amino Acid Residue as a Critical Context-Specific Determinant of the Differential Ability of Mdm2 and MdmX RING Domains to Dimerize

open access: yesFrontiers in Physiology, 2019
Mdm2 and MdmX are related proteins serving in the form of the Mdm2 homodimer or Mdm2/MdmX heterodimer as an E3 ubiquitin ligase for the tumor suppressor p53.
Pavlína Kosztyu   +10 more
doaj   +1 more source

Substrate binding disrupts dimerization and induces nucleotide exchange of the chloroplast GTPase Toc33

open access: yes, 2011
GTPases act as molecular switches to control many cellular processes, including signalling, protein translation and targeting. Switch activity can be regulated by external effector proteins or intrinsic properties, such as dimerization.
Ivo Tews   +19 more
core   +1 more source

Membrane-mediated oligomerization of G protein coupled receptors and its implications for GPCR function

open access: yesFrontiers in Physiology, 2016
The dimerization or even oligomerization of G protein coupled receptors (GPCRs) causes ongoing, controversial debates about its functional role and the coupled biophysical, biochemical or biomedical implications.
Stefan Gahbauer, Rainer A Böckmann
doaj   +1 more source

Atom-dimer and dimer-dimer scatterings in a spin-orbit-coupled Fermi gas

open access: yesPhysical Review A, 2021
Using the diagrammatic approach, here we study how spin-orbit coupling (SOC) affects the fermion-dimer and dimer-dimer scattering lengths in the Born approximation, and benchmark their accuracy with the higher-order approximations. We consider both isotropic and Rashba couplings in three dimensions, and show that the Born approximation gives accurate ...
openaire   +6 more sources

Superbackscattering nanoparticle dimers [PDF]

open access: yesNanotechnology, 2015
The theory and design of superbackscattering nanoparticle dimers are presented. We analytically derive the optimal configurations and the upper bound of their backscattering cross-sections. In particular, it is demonstrated that electrically small nanoparticle dimers can enhance the backscattering by a factor of 6.25 with respect to single dipolar ...
Liberal, Iñigo   +3 more
openaire   +3 more sources

Oxygen dimerization as a defect-driven process in bulk LiNiO2 [PDF]

open access: yes
To explore the possibility of oxygen dimerization — particularly the formation of molecular oxygen-like species — in the bulk of LiNiO2 lithium ion cathodes materials at high states of charge, we conduct a redox-product structure search inspired by ...
Alexander G., Squires   +4 more
core   +1 more source

Acetylation modulates prolactin receptor dimerization [PDF]

open access: yes, 2010
Cytokine-activated receptors undergo extracellular domain dimerization, which is necessary to activate intracellular signaling pathways. Here, we report that in prolactin (PRL)-treated cells, PRL receptor (PRLR) undergoes cytoplasmic loop dimerization ...
Jin-song Gao   +12 more
core   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

open access: yesFEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Dimer Metadynamics

open access: yesJournal of Chemical Theory and Computation, 2017
Sampling complex potential energies is one of the most pressing challenges of contemporary computational science. Inspired by recent efforts that use quantum effects and discretized Feynman's path integrals to overcome large barriers we propose a replica exchange method.
Nava M.   +3 more
openaire   +4 more sources

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

open access: yesFEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa   +2 more
wiley   +1 more source

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