Results 61 to 70 of about 185,470 (305)

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Temperature-Dependent Spin-Driven Dimerization Determines the Ultrafast Dynamics of a Copper(II)-Bound Tripyrrindione Radical

, 2023
Radicals and other open-shell molecules play a central role in chemical transformations and redox chemistry. While radicals are often highly reactive, stable radical systems are desirable for a range of potential applications ranging from materials ...
Vanessa, Huxter, Anshu, Kumar, Benjamin, Thompson, Elisa, Tomat, Ritika, Gautam   +4 more
core   +1 more source

Dimerizing hard spherocylinders in porous media

Condensed Matter Physics
This research focuses on the unique phase behavior of non-spherical patchy colloids in porous environments. Based on the theory of scaled particle (SPT), methods have been refined and applied to analyze the thermodynamic properties of non-spherical ...
V. I. Shmotolokha, M. F. Holovko
doaj   +1 more source

Biased suppression of TP homodimerization and signaling through disruption of a TM GxxxGxxxL helical interaction motif

Journal of Lipid Research, 2013
Thromboxane A2 (TXA2) contributes to cardiovascular disease (CVD) by activating platelets and vascular constriction and proliferation. Despite their preclinical efficacy, pharmacological antagonists of the TXA2 receptor (TP), a G protein-coupled receptor,
Alexander J. Frey, Salam Ibrahim, Scott Gleim, John Hwa, Emer M. Smyth   +4 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Dimerization of

, 2004
Cleavage of the beta-amyloid precursor protein (APP) by the aspartyl protease beta-site APP-cleaving enzyme (BACE) is the first step in the generation of the amyloid beta-peptide, which is deposited in the brain of Alzheimer's disease patients.
Lurman, Glenn, Reiss, Karina, Assfalg-Machleidt, Irmgard, Willem, Michael, Multhaup, Gerd, Westmeyer, G. G., Saftig, Paul, Haass, Christian, Lichtenthaler, Stefan F., Westmeyer, Gil G.   +9 more
core   +1 more source

Merlin isoform 2 dimerization.

, 2023
A). Merlin isoform dimerization reactions with Merlin isoform 1-NL: Merlin isoform 1-GFP, Merlin isoform 2-NL: Merlin isoform 1-GFP and Merlin isoform 2-NL: Merlin isoform 2-GFP.
Nancy Ratner (375065), Craig S. Thomson (11183118), Kye Stachowski (14659932), Nicolas Nassar (2389237), Robert F. Hennigan (7946606)   +4 more
core   +1 more source

HpFBH3 transactivates HpCO7 via binding to the E-boxes in the promoter and may accelerate flower formation in pitaya

Journal of Integrative Agriculture
Hylocereus polyrhizus, also known as pitaya or dragon fruit, is a climbing cactus grown worldwide because of its excellent performance under drought stress and appealing red-purple fruits.
Xiaowei Cai, Ling Xiao, Xiangmei Nie, Qiandong Hou, Sulin Wen, Kun Yang, Xiaopeng Wen   +6 more
doaj   +1 more source

Visualizing Rous Sarcoma Virus Genomic RNA Dimerization in the Nucleus, Cytoplasm, and at the Plasma Membrane

Viruses, 2021
Retroviruses are unique in that they package their RNA genomes as non-covalently linked dimers. Failure to dimerize their genomes results in decreased infectivity and reduced packaging of genomic RNA into virus particles.
Eunice C. Chen, Rebecca J. Kaddis Maldonado, Leslie J. Parent   +2 more
doaj   +1 more source

Dynamics of a Bouncing Dimer [PDF]

Physical Review Letters, 2005
4 pages, 5 figures, Movies: http://physics.clarku.edu/~akudrolli ...
Dorbolo, Stéphane, Volfson, D., Tsimring, L., Kudrolli, A.   +3 more
openaire   +4 more sources