Results 51 to 60 of about 197,285 (307)

Methods for Inducing Homologous Protein Dimerization

Shengwu huaxue yu shengwu wuli jinzhan
Proteins in biological systems rarely act alone, but instead bind with other biomolecules to trigger specific cellular reactions. These biomolecules are usually astonishing number of proteins self-assemble to form dimers, which are both in a relatively ...
GUO Jun-Xia, LIU Sen
doaj   +1 more source

Suppression of cell cycle progression by Jun dimerization protein (JDP2) involves down-regulation of cyclin A2 [PDF]

, 2009
We report here a novel role for Jun dimerization protein-2 (JDP2) as a regulator of the progression of normal cells through the cell cycle. To determine the role of JDP2 in vivo, we generated Jdp2 knock-out (Jdp2KO) mice by targeting exon 1 to disrupt ...
Yu-Chang Huang, Kazunari K. Yokoyama, Koji Nakade, Satoko Masuzaki, Takehide Murata, Naoto Yamaguchi, Hitomi Hasegawa, Yuichi Obata, Jianzhi Pan, Atsushi Yoshiki   +9 more
core  

The Contribution of Different Androgen Receptor Domains to Receptor Dimerization and Signaling

, 2008
The androgen receptor (AR) is a ligand-activated transcription factor of the nuclear receptor superfamily that plays a critical role in male physiology and pathology.
Centenera, Margaret M., Lisa M. Butler, Harris, J., Butler, Lisa M., Margaret M. Centenera, Tilley, W., Harris, Jonathan M., Jonathan M. Harris, Wayne D. Tilley, Tilley, Wayne D., Butler, L., Centenera, M.   +11 more
core   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

CENP-A Ubiquitylation Contributes to Maintaining the Chromosomal Location of the Centromere

Molecules, 2019
The centromere plays an essential role in accurate chromosome segregation, and the chromosomal location of the centromere is determined by the presence of a histone H3 variant, centromere protein A (CENP-A), in centromeric nucleosomes.
Yohei Niikura,, Risa Kitagawa, Katsumi Kitagawa   +2 more
doaj   +1 more source

Synthesis of Butenolides via a Horner-Wadsworth-Emmons Cascading Dimerization Reaction

, 2019
The efficient synthesis of a range of structurally related butenolides has been observed while we were exploring the substrate-scope of a Horner–Wadsworth–Emmons (HWE) reaction.
Everson, Jack, Kiefel, Milton J
core   +1 more source

Sequence Motifs in MADS Transcription Factors Responsible for Specificity and Diversification of Protein-Protein Interaction [PDF]

, 2010
Protein sequences encompass tertiary structures and contain information about specific molecular interactions, which in turn determine biological functions of proteins.
Angenent, G.C., Martijn Fiers, Roeland C H J van Ham, Roeland C. H. J. van Ham, Morabito Giuseppa, Ham, R.C.H.J., van, Aalt D J van Dijk, Angenent Gerco C., Immink, R.G.H., van Dijk, A.D.J., Richard G H Immink, van Dijk Aalt D. J., Morabito, G., van Ham Roeland C. H. J., Dijk, A.D.J., van, Fiers, M.A., Richard G. H. Immink, Giuseppa Morabito, van Ham, R.C.H.J., Aalt D. J. van Dijk, Immink Richard G. H., Gerco C Angenent, Gerco C. Angenent, Fiers Martijn   +23 more
core   +2 more sources

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Pd(OAc)2/Ph3P-catalyzed dimerization of isoprene and synthesis of monoterpenic heterocycles

Beilstein Journal of Organic Chemistry, 2017
The palladium-catalyzed dimerization of isoprene is a practical approach of synthesizing monoterpenes. Though several highly selective methods have been reported, most of them still required pressure or costly ligands for attaining the active system and ...
Dominik Kellner, Maximilian Weger, Andrea Gini, Olga García Mancheño   +3 more
doaj   +1 more source

VEGFR-2 conformational switch in response to ligand binding

eLife, 2016
VEGFR-2 is the primary regulator of angiogenesis, the development of new blood vessels from pre-existing ones. VEGFR-2 has been hypothesized to be monomeric in the absence of bound ligand, and to undergo dimerization and activation only upon ligand ...
Sarvenaz Sarabipour, Kurt Ballmer-Hofer, Kalina Hristova   +2 more
doaj   +1 more source