Results 31 to 40 of about 185,470 (305)

Lactose and Galactose Promote the Crystallization of Human Galectin-10

open access: yesMolecules, 2023
Galectin-10 (Gal-10) forms Charcot–Leyden crystals (CLCs), which play a key role in the symptoms of asthma and allergies and some other diseases. Gal-10 has a carbohydrate-binding site; however, neither the Gal-10 dimer nor the CLCs can bind sugars.
Yu-Fan Fu   +6 more
doaj   +1 more source

Taming highly unstable radical anions and 1,4-organodilithiums by flow microreactors: controlled reductive dimerization of styrenes

open access: yes, 2022
Reduction of styrenes with lithium arenide in a flow microreactor leads to the instantaneous generation of the radical anion of styrenes and subsequent dimerization by fast mixing to yield the corresponding 1,4-dilithium species.
Hideki, Yorimitsu, Yiyuan, Jiang
core   +1 more source

A Novel Mechanism Underlying the Inhibitory Effects of Trastuzumab on the Growth of HER2-Positive Breast Cancer Cells

open access: yesCells, 2022
To improve the efficacy of trastuzumab, it is essential to understand its mechanism of action. One of the significant issues that makes it difficult to determine the precise mechanism of trastuzumab action is the formation of various HER receptor dimers ...
Hamid Maadi, Zhixiang Wang
doaj   +1 more source

Dimers and imaginary geometry [PDF]

open access: yesThe Annals of Probability, 2020
We show that the winding of the branches in a uniform spanning tree on a planar graph converge in the limit of fine mesh size to a Gaussian free field. The result holds assuming only convergence of simple random walk to Brownian motion and a Russo–Seymour–Welsh type crossing estimate, thereby establishing a strong form of universality.
Berestycki, Nathanaël   +2 more
openaire   +7 more sources

Red light activatable chemo-optogenetic dimerization regulates cell apoptosis

open access: yes, 2023
We report a non-phototoxic and non-photobleaching chemo-optogenetic dimerizer that effectively regulates protein-protein proximity inside living cells using far-red light.
Chengjian, Zhou   +4 more
core   +1 more source

RNA Dimerization Promotes PKR Dimerization and Activation [PDF]

open access: yesJournal of Molecular Biology, 2009
The double-stranded RNA (dsRNA)-activated protein kinase [protein kinase R (PKR)] plays a major role in the innate immune response in humans. PKR binds dsRNA non-sequence specifically and requires a minimum of 15-bp dsRNA for one protein to bind and 30-bp dsRNA to induce protein dimerization and activation by autophosphorylation.
Laurie A, Heinicke   +7 more
openaire   +2 more sources

How Does Thymine DNA Survive Ultrafast Dimerization Damage?

open access: yesMolecules, 2016
The photodimerization reaction between the two adjacent thymine bases within a single strand has been the subject of numerous studies due to its potential to induce DNA mutagenesis and possible tumorigenesis in human skin cells.
Hongjuan Wang, Xuebo Chen
doaj   +1 more source

Ribosomal dimers produced by dimers of aurintricarboxylic acid [PDF]

open access: yesFEBS Letters, 1977
Aurintricarboxylic acid (ATA) inhibits protein synthesis in various cell-free systems most likely by interacting with 30 S ribosomal proteins [I]. The blockage is specific for the binding of messengerRNA to the ribosome [2-4]. The binding of ATA to the ribosome itself does not depend on the presence of mRNA.
Fortnagel, Peter, Schnier, Joachim
openaire   +2 more sources

A Single Conserved Amino Acid Residue as a Critical Context-Specific Determinant of the Differential Ability of Mdm2 and MdmX RING Domains to Dimerize

open access: yesFrontiers in Physiology, 2019
Mdm2 and MdmX are related proteins serving in the form of the Mdm2 homodimer or Mdm2/MdmX heterodimer as an E3 ubiquitin ligase for the tumor suppressor p53.
Pavlína Kosztyu   +10 more
doaj   +1 more source

Atom-dimer and dimer-dimer scatterings in a spin-orbit-coupled Fermi gas

open access: yesPhysical Review A, 2021
Using the diagrammatic approach, here we study how spin-orbit coupling (SOC) affects the fermion-dimer and dimer-dimer scattering lengths in the Born approximation, and benchmark their accuracy with the higher-order approximations. We consider both isotropic and Rashba couplings in three dimensions, and show that the Born approximation gives accurate ...
openaire   +6 more sources

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