Results 31 to 40 of about 197,285 (307)
Cells, 2022 To improve the efficacy of trastuzumab, it is essential to understand its mechanism of action. One of the significant issues that makes it difficult to determine the precise mechanism of trastuzumab action is the formation of various HER receptor dimers ...
Hamid Maadi, Zhixiang Wang
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Dimers and imaginary geometry [PDF]
The Annals of Probability, 2020 We show that the winding of the branches in a uniform spanning tree on a planar graph converge in the limit of fine mesh size to a Gaussian free field. The result holds assuming only convergence of simple random walk to Brownian motion and a Russo–Seymour–Welsh type crossing estimate, thereby establishing a strong form of universality.
Berestycki, Nathanaël +2 more
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Transition-State Analysis Reveals Unexpected Coordination-Specific Reactivity that Drives Alkene Dimerization by Sulfated Metal–Organic Frameworks [PDF]
, 2022 Metal–organic frameworks (MOFs) with metal nodes and organic linkers have significant potential as reaction catalysts. However, one major factor impeding the development and use of MOFs as organic reaction catalysts is the detailed under-standing of ...
Daniel, Ess +4 more
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RNA Dimerization Promotes PKR Dimerization and Activation [PDF]
Journal of Molecular Biology, 2009 The double-stranded RNA (dsRNA)-activated protein kinase [protein kinase R (PKR)] plays a major role in the innate immune response in humans. PKR binds dsRNA non-sequence specifically and requires a minimum of 15-bp dsRNA for one protein to bind and 30-bp dsRNA to induce protein dimerization and activation by autophosphorylation.
Laurie A, Heinicke +7 more
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, 2004 Cleavage of the beta-amyloid precursor protein (APP) by the aspartyl protease beta-site APP-cleaving enzyme (BACE) is the first step in the generation of the amyloid beta-peptide, which is deposited in the brain of Alzheimer's disease patients.
Lurman, Glenn +9 more
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Evidence for Dimerization of Dimers in K+ Channel Assembly [PDF]
Biophysical Journal, 1999 Voltage-gated K+ channels are tetrameric, but how the four subunits assemble is not known. We analyzed inactivation kinetics and peak current levels elicited for a variety of wild-type and mutant Kv1.3 subunits, expressed singly, in combination, and as tandem constructs, to show that 1) the dominant pathway involves a dimerization of dimers, and 2 ...
Tu, LiWei, Deutsch, Carol
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Chemical Science, 2021 Oncogenic mutated Ras is a key player in cancer, but despite intense and expensive approaches its catalytic center seems undruggable. The Ras dimer interface is a possible alternative drug target. Dimerization at the membrane affects cell growth signal transduction.
Till Rudack +8 more
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The Role of Structural Flexibility in Plasmon-Driven Coupling Reactions: Kinetic Limitations in the Dimerization of Nitro-Benzenes [PDF]
, 2021 The plasmon-driven dimerization of 4-nitrothiophenol (4NTP) to 4-4’-dimercaptoazobenzene (DMAB) has become a testbed for understanding bimolecular photoreactions enhanced by nanoscale metals, in particular, regarding the relevance of electron transfer ...
Matias, Bargheer +14 more
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How Does Thymine DNA Survive Ultrafast Dimerization Damage?
Molecules, 2016 The photodimerization reaction between the two adjacent thymine bases within a single strand has been the subject of numerous studies due to its potential to induce DNA mutagenesis and possible tumorigenesis in human skin cells.
Hongjuan Wang, Xuebo Chen
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Ribosomal dimers produced by dimers of aurintricarboxylic acid [PDF]
FEBS Letters, 1977 Aurintricarboxylic acid (ATA) inhibits protein synthesis in various cell-free systems most likely by interacting with 30 S ribosomal proteins [I]. The blockage is specific for the binding of messengerRNA to the ribosome [2-4]. The binding of ATA to the ribosome itself does not depend on the presence of mRNA.
Fortnagel, Peter, Schnier, Joachim
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