Results 21 to 30 of about 295,838 (293)

Functional independence of endogenous μ- and δ-opioid receptors co-expressed in cholinergic interneurons

open access: yeseLife, 2021
Class A G-protein-coupled receptors (GPCRs) normally function as monomers, although evidence from heterologous expression systems suggests that they may sometimes form homodimers and/or heterodimers.
Seksiri Arttamangkul   +3 more
doaj   +1 more source

Thermokinetic study of the inactivation reaction of 1-methyl phthalazinium ylids [PDF]

open access: yesJournal of the Serbian Chemical Society, 2003
The present paper consists in a thermokinetic study on the dimerization reactions of 1-methylphthalazinium ylids with –NO2 (ylid 1) and respectively, –O–CH3 (ylid 2) substituents in the p position of the benzoyl radical bound to the ylidic carbanion ...
Carposu Maria   +4 more
doaj   +1 more source

The Dimerization Domain in DapE Enzymes Is Required for Catalysis [PDF]

open access: yes, 2013
The emergence of antibiotic-resistant bacterial strains underscores the importance of identifying new drug targets and developing new antimicrobial compounds.
Gutierrez, Blanca   +9 more
core   +4 more sources

Structural Determinant of β-Amyloid Formation: From Transmembrane Protein Dimerization to β-Amyloid Aggregates

open access: yesBiomedicines, 2022
Most neurodegenerative diseases have the characteristics of protein folding disorders, i.e., they cause lesions to appear in vulnerable regions of the nervous system, corresponding to protein aggregates that progressively spread through the neuronal ...
Nicolas Papadopoulos   +6 more
doaj   +1 more source

Lactose and Galactose Promote the Crystallization of Human Galectin-10

open access: yesMolecules, 2023
Galectin-10 (Gal-10) forms Charcot–Leyden crystals (CLCs), which play a key role in the symptoms of asthma and allergies and some other diseases. Gal-10 has a carbohydrate-binding site; however, neither the Gal-10 dimer nor the CLCs can bind sugars.
Yu-Fan Fu   +6 more
doaj   +1 more source

A Novel Mechanism Underlying the Inhibitory Effects of Trastuzumab on the Growth of HER2-Positive Breast Cancer Cells

open access: yesCells, 2022
To improve the efficacy of trastuzumab, it is essential to understand its mechanism of action. One of the significant issues that makes it difficult to determine the precise mechanism of trastuzumab action is the formation of various HER receptor dimers ...
Hamid Maadi, Zhixiang Wang
doaj   +1 more source

A dimer ABC: [PDF]

open access: yesBulletin of the London Mathematical Society, 2016
We give an overview of recent developments in the theory of dimer models. The viewpoint we take is inspired by mirror symmetry. After an introduction to the combinatorics of dimer models, we will first look at dimers in dynamical systems and statistical mechanics, which can be viewed as coming from the A-model in mirror symmetry.
openaire   +3 more sources

Effects of electron transfer on the stability of hydrogen bonds. [PDF]

open access: yes, 2017
The measurement of the dimerization constants of hydrogen-bonded ruthenium complexes (12, 22, 32) linked by a self-complementary pair of 4-pyridylcarboxylic acid ligands in different redox states is reported.
Heim, Gavin P   +2 more
core   +1 more source

How Does Thymine DNA Survive Ultrafast Dimerization Damage?

open access: yesMolecules, 2016
The photodimerization reaction between the two adjacent thymine bases within a single strand has been the subject of numerous studies due to its potential to induce DNA mutagenesis and possible tumorigenesis in human skin cells.
Hongjuan Wang, Xuebo Chen
doaj   +1 more source

Lattice Dimerization in the Spin-Peierls Compound CuGeO$_3$ [PDF]

open access: yes, 1998
The uniaxial pressure dependences of the exchange coupling and the structural distortion in the dimerized phase of CuGeO$_3$ are analyzed. A minimum magnetic dimerization of 3 % is obtained, incompatible with an adiabatic approach to the spin-Peierls ...
Büchner, B.   +3 more
core   +2 more sources

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