Results 11 to 20 of about 185,470 (305)
Scientific Reports, 2021 Clostridium botulinum neurotoxin serotype A (BoNT/A) is a potent neurotoxin that serves as an effective therapeutic for several neuromuscular disorders via induction of temporary muscular paralysis.
Nicholas G. James +7 more
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Тонкие химические технологии, 2022 Objectives. Catalytic processes involving norbornene (NBN) and norbornadiene (NBD) offer exceptional opportunities for the synthesis of a wide range of hard-to-reach polycyclic hydrocarbons.
S. A. Durakov, A. A. Kolobov, V. R. Flid
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Proceedings of the National Academy of Sciences, 1997 ActA, a surface protein of Listeria monocytogenes , is able to induce continuous actin polymerization at the rear of the bacterium, in the cytosol of the infected cells. Its N-terminal domain is sufficient to induce actin tail formation and movement.
P, Mourrain +5 more
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Chemical Science, 2021 By combining the incorporation of unnatural amino acids, click chemistry, FRET and EPR distance measurements, protein modeling and biomolecular simulations, we obtained an unambiguous Ras dimer structural model and disrupt the dimer by mutagenesis.
Till Rudack +8 more
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mBio, 2021 Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent for coronavirus disease 2019 (COVID-19), encodes two proteases required for replication.
David A. Davis +9 more
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Annals of Mathematics, 2006 We study random surfaces which arise as height functions of random perfect matchings (a.k.a. dimer configurations) on an weighted, bipartite, doubly periodic graph G embedded in the plane. We derive explicit formulas for the surface tension and local Gibbs measure probabilities of these models. The answers involve a certain plane algebraic curve, which
Kenyon, Richard +2 more
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A stay of execution: ATF4 regulation and potential outcomes for the integrated stress response
Frontiers in Molecular Neuroscience, 2023 ATF4 is a cellular stress induced bZIP transcription factor that is a hallmark effector of the integrated stress response. The integrated stress response is triggered by phosphorylation of the alpha subunit of the eukaryotic initiation factor 2 complex ...
Graham Neill, Glenn R. Masson
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SUMO chain-induced dimerization activates RNF4 [PDF]
, 2014 Dimeric RING E3 ligases interact with protein substrates and conformationally restrain the ubiquitin-E2-conjugating enzyme thioester complex such that it is primed for catalysis.
Hay, Ronald T +5 more
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eLife, 2022 Cells steadily adapt their membrane glycerophospholipid (GPL) composition to changing environmental and developmental conditions. While the regulation of membrane homeostasis via GPL synthesis in bacteria has been studied in detail, the mechanisms ...
Florian Bleffert +12 more
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Pari passu dimers of dimers [PDF]
Proceedings of the National Academy of Sciences, 2012 The ErbB/HER network is composed of four receptors and 11 ligands (1). The receptors are known to exist in at least two different conformations (2). In the absence of ligand, EGFR, ErbB3, and ErbB4 exist in a closed or tethered conformation that buries their dimerization arm and prevents unregulated signaling (3).
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