Results 171 to 180 of about 10,718,710 (345)

Proteomics Profiling Reveals Circulating Biomarkers and Dysregulated Pathways in Transthyretin Amyloid Cardiomyopathy. [PDF]

Circ Heart Fail
Lu R, Nalbandian A, Akita K, Teruya S, Bampatsias D, Santos AM, Maurer MS, Shimada YJ.   +7 more
europepmc   +1 more source

Quantitative Proteomics Reveals Protein–Protein Interactions with Fibroblast Growth Factor 12 as a Component of the Voltage-Gated Sodium Channel 1.2 (Nav1.2) Macromolecular Complex in Mammalian Brain*

, 2015
Norelle C. Wildburger, Syed R. Ali, Jim Hsu, Alexander S. Shavkunov, Miroslav N. Nenov, Cheryl F. Lichti, Richard D. LeDuc, Ekaterina Mostovenko, Neli I. Panova-Elektronova, Mark R. Emmett, Carol L. Nilsson, Fernanda Laezza   +11 more
openalex   +1 more source

Infrared spectroscopy of proteins.

Biochimica et Biophysica Acta, 2007
A. Barth
semanticscholar   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Mono-mix strategy enables comparative proteomics of a cross-kingdom microbial symbiosis. [PDF]

PLoS One
Dupuis S, Lingappa UF, Purvine SO, Chiang L, Gallaher SD, Nicora CD, Lipton MS, Merchant SS.   +7 more
europepmc   +1 more source

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

SH3BGRL proteins are thioredoxin fold-containing actin filament pointed end capping proteins (TPECs). [PDF]

Sci Rep
Heiringhoff RS, Marke D, Curth U, Greve JN.   +3 more
europepmc   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

The Proteome of <i>Dictyostelium discoideum</i> Across Its Entire Life Cycle Reveals Sharp Transitions Between Developmental Stages. [PDF]

Proteomes
Banu S, Anusha PV, Beltran-Alvarez P, Idris MM, Wollenberg Valero KC, Rivero F.   +5 more
europepmc   +1 more source