Results 81 to 90 of about 4,998,947 (297)

Protein-protein diffusional encounter

open access: yesBiophysical Journal, 1997
Protein-protein association is clearly a very important process in biology, including events such as signal transduction, immune response, and transcription. Protein-protein association rates are in the range of 103 to 109 M-l S-1, with those in the diffusion-limited regime having rates of .106 M-1 s.
openaire   +3 more sources

Plasmodium falciparum gametogenesis essential protein 1 (GEP1) is a transmission‐blocking target

open access: yesFEBS Letters, EarlyView.
This study shows Plasmodium falciparum GEP1 is vital for activating sexual stages of malarial parasites even independently of a mosquito factor. Knockout parasites completely fail gamete formation even when a phosphodiesterase inhibitor is added. Two single‐nucleotide polymorphisms (V241L and S263P) are found in 12%–20% of field samples.
Frederik Huppertz   +5 more
wiley   +1 more source

Characterization of a novel lipase from Pseudomonas aeruginosa

open access: yesNova Biotechnologica et Chimica, 2019
Lipases cleaving oils into fatty acids and glycerol are of great interest for the use in increasing the efficiency of fuels. In this work, a novel lipase from Pseudomonas aeruginosa, P.
Berdiev Nodir Sh.   +4 more
doaj   +1 more source

Biophysical analysis of angiotensin II and amyloid‐β cross‐interaction in aggregation and membrane disruption

open access: yesFEBS Letters, EarlyView.
Angiotensin II (AngII), a neuropeptide, interacts with amyloid‐β (Aβ), a key player in Alzheimer's disease. This study reveals that AngII reduces Aβ aggregation and membrane disruption in vitro. Biophysical assays and molecular modeling suggest AngII binds disordered Aβ forms, potentially modulating early amyloidogenic events and contributing to ...
Mohsen Habibnia   +5 more
wiley   +1 more source

Protein-Protein Interactions [PDF]

open access: yesRevista Brasileira de Ciências Farmacêuticas, 2004
Graziella Pedrazzi, Igor Stagljar
openaire   +5 more sources

Drosophila as a Model for Studying the Roles of Lamins in Normal Tissues and Laminopathies

open access: yesCells
Nuclear processes are fundamental to the regulation of cellular, tissue, and organismal function, especially in complex multicellular systems. Central to these processes are lamins and lamin-associated proteins, which contribute to nuclear structure ...
Aleksandra Zielińska   +3 more
doaj   +1 more source

4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase in malaria parasites and enhances atovaquone efficacy

open access: yesFEBS Letters, EarlyView.
Atovaquone is an antimalarial requiring potentiation for sufficient efficacy. We pursued strategies to enhance its activity, showing that 4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase, decreasing ubiquinone biosynthesis. Since atovaquone competes with ubiquinol in mitochondria, 4‐nitrobenzoate facilitates its action, potentiating ...
Ignasi Bofill Verdaguer   +7 more
wiley   +1 more source

Paper electrophoresis as a quantitative method. Serum proteins [PDF]

open access: green, 1955
William P. Jencks   +2 more
openalex   +1 more source

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