Results 81 to 90 of about 4,692,035 (317)
Scientific ReportsHeteromeric complexes observed within co-formulated products represent a unique class of impurities that are poorly understood in terms of their biochemical, biophysical, structural, and functional attributes.
Jennifer B. Nguyen +13 more
doaj +1 more source
Milk Proteins From Expression to Food
, 2014 Understanding of the interactions of milk proteins in complex food systems continues to progress, resulting in specialized milk-protein based applications in functional foods, and in protein ingredients for specific health applications.
Boland, Michael J.
core
Heat shock proteins in tendinopathy: novel molecular regulators [PDF]
, 2012 Tendon disorders-tendinopathies-are the primary reason for musculoskeletal consultation in primary care and account for up to 30% of rheumatological consultations.
Neal L. Millar +3 more
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FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
Evolvability of Chaperonin Substrate Proteins
, 2009 Molecular chaperones ensure that their substrate proteins reach the functional native state, and prevent their aggregation. Recently, an additional function was proposed for molecular chaperones: they serve as buffers (_capacitors_) for evolution by ...
Tobias Maier +7 more
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Insights into the regulation of intrinsically disordered proteins in the human proteome by analyzing sequence and gene expression data [PDF]
, 2009 Background: Disordered proteins need to be expressed to carry out specified functions; however, their accumulation in the cell can potentially cause major problems through protein misfolding and aggregation.
Edwards, Y.J.K. +11 more
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FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Recruitment of proteins to modulate protein-protein interactions
Chemistry & Biology, 1999 The use of a 'borrowed' protein surface to either enhance or inhibit the interaction of a small ligand with its protein target has been reported recently. This approach represents a general method for modulating protein-protein interactions and may find many applications in both biology and medicine.
openaire +2 more sources
Photophysical Properties of Fluorescent Probe Thioflavin T in Crowded Milieu
Journal of Spectroscopy, 2017 Thioflavin T (ThT) is a widely used fluorescent probe of amyloid fibrils, which accompanies many serious neurodegenerative and other diseases. Until recently, examinations of processes of amyloid fibril formation in vitro were conducted in solutions ...
Natalia P. Rodina +5 more
doaj +1 more source
The energetics of nucleotide binding to RAS proteins
, 1992 Ras proteins are a special class of proteins that mediate cell growth signals. Their importance lies in the fact that they are products of a proto-oncogene.
Worth, Graham A., Worth, Graham Alan.
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