Results 91 to 100 of about 288,185 (387)

Evaluation of Proteinuria [PDF]

Mayo Clinic Proceedings, 1994
Proteinuria, a common finding on urinalysis, may indicate the presence of a wide variety of medical conditions, some of which are benign and associated with a favorable prognosis (such as orthostatic proteinuria) and others of which have more serious implications (such as glomerular disease or multiple myeloma).
openaire   +2 more sources

Adaptive Antioxidant Nanomedicines Inhibit Ferroptosis in Renal Tubular Epithelial Cells to Alleviate Diabetic Kidney Disease

Advanced Science, EarlyView.
In this study, an adaptive antioxidant nanodrug (AAN) is developed through the self‐polymerization of L‐selenocysteine. The AAN exhibits dual functionalities: antioxidant activity (scavenging reactive oxygen species) and mitochondrial targeting. Moreover, the released selenium (Se) participates in the synthesis of glutathione peroxidase 4 (GPX4), which
Zerun Liu, Ting Huang, Ying Hong, Yuqi Yang, Wensheng Chen, Qingtao Zeng, Qiaohui Chen, Yongqi Yang, Xiaohong Ying, Wan Zeng, Ziyu Wu, Tianjiao Zhao, Xuesi Wan, Jianlin Chen, Kelong Ai, Qiong Huang   +15 more
wiley   +1 more source

Use of Antihypertensive Agents and Association With Risk of Adverse Outcomes in Chronic Kidney Disease: Focus on Angiotensin-Converting Enzyme Inhibitors and Angiotensin Receptor Blockers. [PDF]

, 2018
Background Our objective was to determine patterns of antihypertensive agent use by stage of chronic kidney disease (CKD) and to evaluate the association between different classes of antihypertensive agents with nonrenal outcomes, especially in advanced ...
Johansen, Kirsten L, Ku, Elaine, Lin, Feng, McCulloch, Charles E, Vittinghoff, Eric   +4 more
core  

Risk Factors Triggering the Development of Preeclampsia in Pregnant Women with Isolated Gestational Proteinuria and Perinatal Outcomes

Haseki Tıp Bülteni, 2019
Aim:To determine the risk factors for preeclampsia in isolated gestational proteinuria and to compare perinatal outcomes between women who did and did not develop preeclampsia.Methods:Seventy-six pregnants, who were diagnosed with isolated proteinuria ...
Betül Dündar, Burcu Dinçgez Çakmak, Ülkü Ayşe Türker   +2 more
doaj   +1 more source

Proteinuria in Dent disease: a review of the literature

Pediatric nephrology (Berlin, West), 2016
BackgroundDent disease is a rare X-linked recessive proximal tubulopathy caused by mutations in CLCN5 (Dent-1) or OCRL (Dent-2). As a rule, total protein excretion (TPE) is low in tubular proteinuria compared with glomerular disease. Several authors have
Y. Van Berkel, M. Ludwig, J. V. van Wijk, A. Bökenkamp   +3 more
semanticscholar   +1 more source

Proteinuria Thresholds Are Irrational: A Call for Proteinuria Indexing [PDF]

Nephron Clinical Practice, 2010
Current guidelines for chronic kidney disease (CKD) diagnosis, referral and management are based on absolute thresholds of proteinuria/albuminuria with no reference to the residual nephron mass or function. This is illogical since the severity of proteinuria is a direct reflection of the number of filtering nephrons as well as their pathology and the ...
Timothy Ellam, Meguid El Nahas
openaire   +2 more sources

Inhibition of AMPKα Pathway by Podocyte GOLM1 Exacerbates Diabetic Nephrology in Mice

Advanced Science, EarlyView.
Podocyte Golgi membrane protein 1 interacts with epidermal growth factor receptor to inhibit peroxisome proliferator activated receptor γ, and then inactivates adenosine monophosphate activated protein kinase α pathway, which facilitates diabetes‐related inflammation, oxidative damage, apoptosis, and renal dysfunction.
Peng Xu, Kaiqiang Li, Huasong Liu, Aibo Xu, Zhewei Zhang, Yimin Yang, Xiaobo Lai, Ke Hao, Kui Fang, Zeyu Lai, Xiping Ou, Yuqun Cai, Zhen Wang, Keda Lu, Wanli Jiang   +14 more
wiley   +1 more source

The Accumulation of VEGFA in the Glomerular Basement Membrane and Its Relationship with Podocyte Injury and Proteinuria in Alport Syndrome. [PDF]

PLoS ONE, 2015
The pathogenesis of proteinuria in Alport syndrome (AS) remains unclear. Vascular endothelial growth factor A (VEGFA) is a key regulator of the glomerular filtration barrier (GFB).
Haiyan Wang, Zhihui Yue, Jinlang Wu, Ting Liu, Ying Mo, Xiaoyun Jiang, Liangzhong Sun   +6 more
doaj   +1 more source

Risk factors of proteinuria in renal cell carcinoma patients treated with VEGF inhibitors: a secondary analysis of pooled clinical trial data

British Journal of Cancer, 2016
Background:Proteinuria is a common adverse effect of vascular endothelial growth factor targeted agents, particularly in metastatic renal cell carcinoma (mRCC).
M. Sorich, A. Rowland, G. Kichenadasse, R. Woodman, A. Mangoni   +4 more
semanticscholar   +1 more source

Lenvatinib Plus Paclitaxel as Second‐Line Therapy for Advanced Gastric Cancer Patients: A Dose Escalation Exploratory Study

Advanced Science, EarlyView.
This study determines the maximum tolerated dose of lenvatinib in combination with paclitaxel as second‐line therapy for advanced gastric cancer patients. A dynamic network biomarker panel associated with patient prognosis and response to treatment is established.
Chenfei Zhou, Jinling Jiang, Liting Guo, Wenqi Xi, Junwei Wu, Qu Cai, Jun Ji, Feng Qi, Jun Zhang   +8 more
wiley   +1 more source