Results 51 to 60 of about 187,783 (355)

Chewing areca nut as an independent risk factor for proteinuria in middle-aged men

Kaohsiung Journal of Medical Sciences, 2013
No previous large-scale research has reported the association of chewing areca nut (AN) with proteinuria. The aim of this study was to investigate such an association in men over a 7-year study.
Wen-Hsin Liu, Chih-Cheng Hsu, Yueh-Han Hsu   +2 more
doaj   +1 more source

The Accumulation of VEGFA in the Glomerular Basement Membrane and Its Relationship with Podocyte Injury and Proteinuria in Alport Syndrome. [PDF]

PLoS ONE, 2015
The pathogenesis of proteinuria in Alport syndrome (AS) remains unclear. Vascular endothelial growth factor A (VEGFA) is a key regulator of the glomerular filtration barrier (GFB).
Haiyan Wang, Zhihui Yue, Jinlang Wu, Ting Liu, Ying Mo, Xiaoyun Jiang, Liangzhong Sun   +6 more
doaj   +1 more source

Membranoproliferative glomerulonephritis in patients with chronic venous catheters: a case report and literature review. [PDF]

, 2014
Chronic indwelling catheters have been reported to be associated with membranoproliferative glomerulonephritis (MPGN) via the activation of the classical complement pathway in association with bacterial infections such as coagulase negative ...
Nast, Cynthia C, Pham, Phuong-Chi T, Pham, Phuong-Thu T, Sy, John   +3 more
core   +2 more sources

Kidney Fibrosis In Vitro and In Vivo Models: Path Toward Physiologically Relevant Humanized Models

Advanced Healthcare Materials, EarlyView.
This review discusses kidney diseases with a focus on kidney fibrosis and the models currently used. It highlights the limitations of animal and 2D in vitro models in replicating human kidney anatomy and physiology. Consequently, there is a significant need for humanized 3D in vitro models, such as 3D cell aggregates, membranes and hydrogels, on‐chip ...
Gabriele Addario, Lorenzo Moroni, Carlos Mota   +2 more
wiley   +1 more source

Impact of preexisting proteinuria on the development of regorafenib-induced problematic proteinuria in real-world metastatic colorectal cancer treatment

Scientific Reports
Regorafenib is the first multikinase inhibitor for treating metastatic colorectal cancer (mCRC). Proteinuria is a frequently encountered adverse effect, regardless of prior administration of vascular endothelial growth factor inhibitors. Herein, we aimed
Yoshitaka Saito, Yoh Takekuma, Yoshito Komatsu, Mitsuru Sugawara   +3 more
doaj   +1 more source

Association of Persistent, Incident, and Remittent Proteinuria With Stroke Risk in Patients With Diabetes Mellitus or Prediabetes Mellitus

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2017
BackgroundProteinuria often changes dynamically, showing either regression or progression. The impact of changes in proteinuria on future stroke risk remains largely unknown.
Anxin Wang, Ruixuan Jiang, Zhaoping Su, Jia Zhang, Xingquan Zhao, Shouling Wu, Xiuhua Guo   +6 more
doaj   +1 more source

Association between proteinuria trajectories and outcomes in critically ill patients with sepsis or shock.

PLoS ONE, 2022
BackgroundProteinuria results from kidney damage and can be a predictor of illness severity and mortality in the intensive care unit (ICU). However, the optimal timing of proteinuria measurements and the reference values remain undetermined.
Raphael Monge, Charlotte Oris, Matthieu Jabaudon, Marina Braïlova, Emmanuel Futier, Vincent Sapin, Bruno Pereira, Alexandre Lautrette   +7 more
doaj   +1 more source

GABP Promotes Mesangial Cell Proliferation and Renal Fibrosis Through GLI1 in Diabetic Nephropathy

Advanced Science, EarlyView.
GABP is found to promote mesangial cell proliferation and ECM deposition through GLI1, while inhibiting GABP or GLI1 prevents the progression of DN by reducing ECM and fibrosis. The research results indicate that a potential therapeutic approach based on inhibiting mesangial cell proliferation and ECM accumulation can effectively treat DN, while GABP ...
Lei Du, Sijie Liu, Yinfei Lu, Dongxue Ren, Xiujuan Yu, Yue Hu, Tingting Yang, Qun Yang, Jingxian Ming, Jiawei Zhang, Xiaoxing Yin, Qian Lu   +11 more
wiley   +1 more source

Changes in proteinuria and the risk of myocardial infarction in people with diabetes or pre-diabetes: a prospective cohort study

Cardiovascular Diabetology, 2017
Background The relationship between changes in proteinuria and myocardial infarction (MI) remains unclear in people with diabetes or pre-diabetes. We aimed to evaluate the predictive value and independent role of changes in proteinuria over a 2-year ...
Anxin Wang, Yang Sun, Xiaoxue Liu, Zhaoping Su, Junjuan Li, Yanxia Luo, Shuohua Chen, Jianli Wang, Xia Li, Zhan Zhao, Huiping Zhu, Shouling Wu, Xiuhua Guo   +12 more
doaj   +1 more source

Identifying chemokines as therapeutic targets in renal disease: Lessons from antagonist studies and knockout mice [PDF]

, 2004
Chemokines, in concert with cytokines and adhesion molecules, play multiple roles in local and systemic immune responses. In the kidney, the temporal and spatial expression of chemokines correlates with local renal damage and accumulation of chemokine ...
Abdi R, Anders HJ, Anders HJ, Anders HJ, Bruhl H, Burne-Taney MJ, Feng L, Fituri O, Fujinaka H, Garcia GE, Grone HJ, Keane MP, Mack M, Miura M, Murphy PM, Nath KA, Perez de Lema G, Rollins BJ, Romagnani P, Segerer S, Segerer S, Segerer S, Tang WW, Taub DD, Tesch GH, Tokuda A, Topham PS, Vielhauer V, Vielhauer V, Wada T, Wang Y, Wenzel U, Wu X, Wu X, Zernecke A   +34 more
core   +1 more source