Results 61 to 70 of about 162,405 (296)
Advanced Science, EarlyView.Cryo‐electron microscopy structures reveal two distinct neutralization mechanisms of fully human monoclonal antibodies targeting the Shiga toxin 1a B subunit. RDS059 occludes the Gb3 receptor‐binding site, whereas RDS045 engages a lateral quaternary epitope to disrupt holotoxin assembly.
Jianting Ke +10 more
wiley +1 more source
Cardiovascular Diabetology, 2017 Background The relationship between changes in proteinuria and myocardial infarction (MI) remains unclear in people with diabetes or pre-diabetes. We aimed to evaluate the predictive value and independent role of changes in proteinuria over a 2-year ...
Anxin Wang +12 more
doaj +1 more source
Evaluation of renal profile in asymptomatic HIV patients with special reference to proteinuria
, 2015 Introduction: Renal disease has now become a well-recognised complication of HIV infection. If not recognized early it frequently progresses to end stage renal disease, thus becoming a major cause of morbidity and mortality.
Promil Jain +4 more
core +1 more source
Proteinuria in hypertensive crisis
, 2022 1. Dipstick proteinuria was an independent prognostic factor for all-cause mortality in patients with hypertensive crisis. 2. The risk of all-cause mortality increased in a dose-dependent manner according to the degree of dipstick proteinuria.
Jeong-Hun Shin (12207485) +3 more
core +1 more source
T‐Cell Remodeling in Renal Fibrosis: From Acute Injury to Chronic Kidney Disease
Advanced Science, EarlyView.This Review presents renal fibrosis as a sequence of overlapping T‐cell programs, from chemokine‐guided recruitment and metabolic activation to maladaptive polarization, tertiary lymphoid structure formation, tissue residency, exhaustion, and senescence.
Qianhui Li +11 more
wiley +1 more source
Student's Journal of Health Research Africa, 2023 Objective: This prospective cohort study aimed to investigate the relationship between changes in proteinuria and the risk of myocardial infarction (MI) in individuals with diabetes or pre-diabetes.
Sanjay Kumar +3 more
doaj
Chinese Expert Consensus on the Clinical Application of Finerenone in Geriatric Comorbidities
AGING MEDICINE, EarlyView.Mineralocorticoid receptor (MR) overactivation drives inflammation, oxidative stress, and fibrosis in the heart, kidneys, and vasculature, leading to cardiorenal dysfunction. MR signaling promotes hypertrophy, remodeling, and injury through pathways like oxidative stress and inflammation, resulting in vascular stiffness and progressive organ damage ...
Xiaoming Wang, Cuntai Zhang
wiley +1 more source
Association between proteinuria and placental pathology in preeclampsia: A retrospective study
SAGE Open Medicine, 2021 Introduction: Preeclampsia develops due to placental insufficiency and systemic proinflammatory and antiangiogenic mediator release, with ensuing systemic endothelial dysfunction.
Dominique Suzanne Genest +3 more
doaj +1 more source
American Journal of Medical Genetics Part A, EarlyView.ABSTRACT Glucocorticoid resistance syndrome (GRS) is a rare hereditary disorder caused by pathogenic variants in NR3C1, characterized by marked phenotypic heterogeneity and frequent misdiagnosis as primary aldosteronism or subclinical Cushing's syndrome.
Sufang Yun +7 more
wiley +1 more source
Proteinuria in atherosclerotic renovascular disease
, 1999 Proteinuria is well described in atherosclerotic renovascular disease (ARVD), but the prevalence is unknown, and the pathogenesis may vary between patients. Substantial proteinuria (> 2 g/day) however, would be regarded by many as atypical of ARVD. We
Suresh, M. +4 more
core +7 more sources