Results 51 to 60 of about 162,405 (296)

Nuclear Pore Mechanotransduction in Oncology: A Structural Axis of Vulnerability for Targeted Intervention

Advanced Materials, EarlyView.
Cancer‐associated NPC remodeling creates a high‐flux, low‐stringency nuclear state that supports malignant adaptation but increases mechanical fragility. Targeting the FG‐barrier or NPC scaffold may drive mechanostat failure, envelope rupture, DNA damage, and loss of nuclear integrity.
Sílvio Terra Stefanello, Caren Rigon Mizdal, Aline Franzen da Silva, Yun Qian, Wei‐En Yuan, Victor Shahin   +5 more
wiley   +1 more source

Chylous Urine with Massive Proteinuria – Not Every Proteinuria Requires Renal Biopsy!

Indian Journal of Kidney Diseases, 2023
Chyluria is a condition characterized by abnormal leakage of lymphatic fluid into the urinary system. It is most commonly caused by filarial parasites in the endemic Indian population.
Siddharth Herur, Ankit Tiwari, Vijay Chander Bukka, M. Niranjan, Swarnalatha Guditi   +4 more
doaj   +1 more source

Maximizing Nanoscale Disorder in Block Copolymers for Orientation‐Independent SERS Platform Toward Non‐Invasive Diagnostics

Advanced Science, EarlyView.
Maximizing Nanoscale Disorder in Block Copolymers for Orientation‐Independent SERS Platform toward Non‐Invasive Diagnostics is a nature‐inspired strategy that engineers controlled randomness within block copolymer lamellae to achieve optical isotropy without compromising nanoscale periodicity.
Jin Man Kim, Wonsik Kim, Wansun Kim, Yeon‐Hee Kim, Samjin Choi, Jang Hwan Kim, Hyeong Min Jin   +6 more
wiley   +1 more source

Changes in urine dipstick proteinuria and risk of dialysis-requiring acute kidney injury and subsequent ESRD

Scientific Reports
Acute kidney injury (AKI) is associated with poor prognosis. Dialysis-requiring AKI and end-stage renal disease (ESRD) represents the severe form of AKI. Proteinuria is a reliable prognostic factor for kidney diseases.
Sung Keun Park, Min-Ho Kim, Chang-Mo Oh, Eunhee Ha, Soonsu Shin, Sungjin Kim, Min Hyung Jung, Dosang Cho, Jae-Hong Ryoo, Ah Rah Lee   +9 more
doaj   +1 more source

Proteinuria, body mass index, and the risk of new-onset heart failure: a prospective cohort study in Northern China

, 2023
Some studies have reported that body-mass index (BMI) and proteinuria are risk factors for heart failure (HF). However, the combined effect of BMI and proteinuria on HF is still unclear.
Tse, G.
core  

ANGPTL4 Exacerbates Renal Injury in Diabetic Kidney Disease by Impairing Podocyte Lipophagy via Compromised Lysosomal Degradative Function

Advanced Science, EarlyView.
In diabetic kidney disease, elevated podocyte ANGPTL4 is linked to reduced TFEB nuclear localization and compromised lysosomal degradative function. These changes impair podocyte lipophagy and promote lipid‐droplet accumulation and podocyte injury, which may contribute to renal injury progression.
Xiaojing Liu, Shimin Jiang, Zhenkun Yang, Shunlai Shang, Jiayi Li, Guming Zou, Cheng Zhou, Wenge Li   +7 more
wiley   +1 more source

Relationships of risk factors for pre-eclampsia with patterns of occurrence of isolated gestational proteinuria during normal term pregnancy.

PLoS ONE, 2011
BackgroundIsolated gestational proteinuria may be part of the pre-eclampsia disease spectrum. Confirmation of its association with established pre-eclampsia risk factors and higher blood pressure in uncomplicated pregnancies would support this concept ...
Corrie Macdonald-Wallis, Debbie A Lawlor, Jon Heron, Abigail Fraser, Scott M Nelson, Kate Tilling   +5 more
doaj   +1 more source

Renal vein obstruction and orthostatic proteinuria: a review [PDF]

, 2010
The cause of orthostatic proteinuria is not clear but may often relate to obstruction of the left renal vein in the fork between the aorta and the superior mesenteric artery (=renal nutcracker).
M.B.M. Mazzoni, Kottanatu, Lisa, Bianchetti, Mario G, Gregorio P. Milani, Simonetti, Giacomo D, M. Ragazzi, Lisa Kottanatu, E.F. Fossali, M. G. Bianchetti, Emilio F. Fossali, L. Kottanatu, Milani, Gregorio P, Giacomo D. Simonetti, Mario G. Bianchetti, Ragazzi, Monica, G.P. Milani, Mazzoni, Marta B M, Monica Ragazzi, G. D. Simonetti, Fossali, Emilio F, Marta B. M. Mazzoni   +20 more
core   +2 more sources

SPARC Drives Podocyte Mitochondrial Damage and Ferroptosis in Diabetic Kidney Disease Following Klotho Deficiency

Advanced Science, EarlyView.
Klotho deficiency promotes podocyte mitochondrial dysfunction and ferroptosis through activation of the PKCα/CUX1/SPARC/TGFβ‐RII axis. SPARC emerges as a key mediator linking Klotho loss to podocyte injury in DKD and other kidney injury models, suggesting broader implications for CKD progression.
Qing Yang, Huimin Jiang, Chenyang Xiong, Xindi Zhou, Qinqin Tan, Han Xiao, Lan Qiu, Chun Gan, Yaxi Chen, Haiping Yang, Wei Jiang, Qiu Li   +11 more
wiley   +1 more source

Association of Persistent, Incident, and Remittent Proteinuria With Stroke Risk in Patients With Diabetes Mellitus or Prediabetes Mellitus

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2017
BackgroundProteinuria often changes dynamically, showing either regression or progression. The impact of changes in proteinuria on future stroke risk remains largely unknown.
Anxin Wang, Ruixuan Jiang, Zhaoping Su, Jia Zhang, Xingquan Zhao, Shouling Wu, Xiuhua Guo   +6 more
doaj   +1 more source