Results 101 to 110 of about 135,581 (337)

From pathogen to “living drug factory” innovative strategies and clinical translation of bacteria as programmable intelligent vectors for cancer therapy

BMEMat, EarlyView.
Engineered bacteria serve as smart, living therapeutics that target tumors, deliver drugs, and remodel immunosuppressive microenvironments. This review highlights their potential to potentiate immunotherapy, radiotherapy, and chemotherapy, offering a promising paradigm for precise and synergistic cancer treatment. Abstract The dynamic interplay between
Haonan Shen, Weichen Zhang, Gaoli Niu, Li Wang, Ruiyan Li, Yueyue Fan, Feixue Lu, Lingling Xu, Xiaoyuan Ji, Yong Kang   +9 more
wiley   +1 more source

Comparative genomics of transcriptional regulation of methionine metabolism in Proteobacteria. [PDF]

, 2014
Methionine metabolism and uptake genes in Proteobacteria are controlled by a variety of RNA and DNA regulatory systems. We have applied comparative genomics to reconstruct regulons for three known transcription factors, MetJ, MetR, and SahR, and three ...
Pavel S Novichkov, Sofia S. Sherstneva, Inna A Suvorova, Tatiana D. Kholina, Sofia S Sherstneva, Dmitry A Rodionov, Inna A. Suvorova (663934), Inna A. Suvorova, Mikhail S Gelfand, Pavel S. Novichkov (22469), Mikhail S. Gelf, Semen A. Leyn, Pavel S. Novichkov, Dmitry A. Rodionov, Mikhail S. Gelfand (10782), Semen A. Leyn (663933), Dmitry A. Rodionov (11371), Semen A Leyn, Tatiana D Kholina, Sofia S. Sherstneva (663936), Tatiana D. Kholina (663935)   +20 more
core   +1 more source

Profiling the secretomes of plant pathogenic Proteobacteria

FEMS Microbiology Reviews, 2005
Secreted proteins are central to the success of plant pathogenic bacteria. They are used by plant pathogens to adhere to and degrade plant cell walls, to suppress plant defence responses, and to deliver bacterial DNA and proteins into the cytoplasm of plant cells.
Preston, G, Studholme, D, Caldelari, I
openaire   +3 more sources

Probiotic spore‐based bioresponsive drug delivery for reversing inflammatory bowel disease and its associated anxiety and depression

BMEMat, EarlyView.
A probiotic spore‐based drug delivery system (BCS‐Que@ApNPs) provides excellent targeted delivery, bioresponsive drug release, and long‐term retention (over 48 h), making it suitable for oral treatment of inflammatory bowel disease and its associated anxiety and depression.
Qingling Song, Beiyang Xue, Yao Li, Chuangxi Zhou, Junfei Yang, Yunfei Li, Lingwen Ding, Yun Zhang, Hongjuan Zhao, Lei Wang   +9 more
wiley   +1 more source

Meta-analysis of the association between gut microbiota and postpartum depression

Journal of Psychosomatic Obstetrics and Gynecology
Objective This study aimed to explore the association between gut microbiota and postpartum depression (PPD) through meta-analysis, providing a basis for effective clinical preventive interventions.​Methods Systematic searches were conducted in English ...
Yan Guo, Wangxiang Chen
doaj   +1 more source

Specialized Metabolites from Methylotrophic Proteobacteria  [PDF]

Current Issues in Molecular Biology, 2019
Biosynthesized small molecules known as specialized metabolites often have valuable applications in fields such as medicine and agriculture. Consequently, there is always a demand for novel specialized metabolites and an understanding of their bioactivity.
openaire   +2 more sources

Gut‐microbiota‐brain Axis and post‐traumatic epilepsy

Epilepsia Open, EarlyView.
Abstract There has been growing evidence that perturbations in gut‐microbiota‐brain axis (GMBA) are involved in mechanisms of chronic sequelae of traumatic brain injury (TBI). This review discusses the connection between GMBA and post‐traumatic epilepsy (PTE), the latter being a common outcome of TBI.
Andrey Mazarati
wiley   +1 more source

Genetic evidence for a periplasmic protein as a third component for a subset of NtrYX family two-component systems

Journal of Bacteriology
PlrSR, a member of the NtrYX family of two-component regulatory systems (TCSs), is required for the classical bordetellae, including the causative agent of whooping cough, Bordetella pertussis, to persist in the lower respiratory tract.
Alexa R. Wolber, Liliana S. McKay, Richard M. Johnson, Zain T. Hameed, Katlyn B. Mote, Steven M. Julio, Peggy A. Cotter   +6 more
doaj   +1 more source

Intestinal microbiome alterations in pediatric epilepsy: Implications for seizures and therapeutic approaches

Epilepsia Open, EarlyView.
Abstract The intestinal microbiome plays a pivotal role in maintaining host health through its involvement in gastrointestinal, immune, and central nervous system (CNS) functions. Recent evidence underscores the bidirectional communication between the microbiota, the gut, and the brain and the impact of this axis on neurological diseases, including ...
Teresa Ravizza, Greta Volpedo, Antonella Riva, Pasquale Striano, Annamaria Vezzani   +4 more
wiley   +1 more source

A Third Class: Functional Gibberellin Biosynthetic Operon in Beta-Proteobacteria [PDF]

, 2018
The ability of plant-associated microbes to produce gibberellin A (GA) phytohormones was first described for the fungal rice pathogen Gibberella fujikuroi in the 1930s.
John E. Bieber, Schmidt-Dannert, Mark, Nett, Ryan, Raimund Nagel, Nagel, Raimund, Reuben J. Peters, Ryan S. Nett, Mark G. Schmidt-Dannert, Bieber, John, Peters, Reuben   +9 more
core   +1 more source