Results 121 to 130 of about 7,774 (200)

Bone biology in aging periodontal and peri‐implant tissues

Periodontology 2000, EarlyView.
Abstract Background Periodontal disease is an age‐related chronic inflammatory condition leading to tooth loss. Dental implants are an option for replacement of lost teeth in older adults. However, age‐related changes to alveolar bone may have pathological implications for its role in supporting the dentition and dental implants.
Dalia Rasheed Issa, Giuseppe Intini, Daniel Clark   +2 more
wiley   +1 more source

Effect of carbamazepine on the pharmacokinetics of vepdegestrant, a PROteolysis TArgeting Chimera estrogen receptor degrader, in healthy adults. [PDF]

Br J Clin Pharmacol
Wang H, Winton JA, Matschke KT, Stouffs A, Lee KC, Zhang Y, Qiao W, Tan W.   +7 more
europepmc   +1 more source

Synergistic Regulation of Biomaterials and Macrophages: A Novel Paradigm in Immunotherapy

MedComm – Biomaterials and Applications, Volume 5, Issue 4, December 2026.
Bioengineered materials mediating the modulation of macrophage plasticity and inflammatory signals in the tumor microenvironment effectively remodel immunoregulatory states, boost antitumor immunity, and promote tissue repair, achieving synergistic therapeutic outcomes.
Jiayu Zhang, Songhang Xing, Shanshan Zhang, Yuan Hao, Xiaojie Qu, Wurihan Bao, Manwei Hao, Han Sun, Mingyuan Dong, Huiling Zhang, Dan Huang, Yiqi Wang, Xuanjie Jiang, Xiaoyu Pu, Yanyan Chi, Xingtong Wang, Xuefeng Li   +16 more
wiley   +1 more source

Downsizing the Histone H3–H4 Quaternary Structure Into Foldamer Mimetics Yields High‐Affinity and Cell‐Permeable Ligands of ASF1

Angewandte Chemie, Volume 138, Issue 41, 5 October 2026.
We present a foldamer strategy to downsize the histone H3‐H4 quaternary structure into high‐affinity, medium‐sized binders (∼2 kDa) for the histone chaperone ASF1. Our peptide‐oligourea chimeras, designed through structure‐guided optimization and foldamer chemistry, recapitulate the natural H3‐H4 dimer binding mode while demonstrating plasma stability ...
Bo Li, Marie E. Perrin, Emma Maillard, Arthur Vitard, Gwenaëlle Moal, Johanne Mbianda, Christophe André, Magda Teixeira Nunes, Marie Vandamme, Guillaume Pinna, Céline Douat, Emmanuelle Thinon, Raphaël Guerois, Pierre Legrand, Gilles Guichard, Francoise Ochsenbein   +15 more
wiley   +2 more sources

Crizotinib-based proteolysis targeting chimera suppresses gastric cancer by promoting MET degradation. [PDF]

Cancer Sci, 2023
Chen JJ, Jin JM, Gu WJ, Zhao Z, Yuan H, Zhou YD, Nagle DG, Xi QL, Zhang XM, Sun QY, Wu Y, Zhang WD, Luan X.   +12 more
europepmc   +1 more source

Targeting B‐Cell‐Activating Factor and Its Receptor in Immune Thrombocytopenia and Warm Autoimmune Hemolytic Anemia

American Journal of Hematology, Volume 101, Issue 11, Page 2836-2852, November 2026.
ABSTRACT Current treatments for immune thrombocytopenia (ITP) and warm autoimmune hemolytic anemia (wAIHA), rare autoimmune diseases in which autoreactive B cells play a major role, can lead to high response rates; however, for many patients these responses are not durable or maintained after treatment discontinuation.
Matthieu Mahévas, Nichola Cooper, Vickie McDonald, Karina Yazdanbakhsh, Wilma Barcellini   +4 more
wiley   +1 more source

Methylated Nucleotide-Based Proteolysis-Targeting Chimera Enables Targeted Degradation of Methyl-CpG-Binding Protein 2. [PDF]

J Am Chem Soc, 2023
Wang Z, Liu J, Qiu X, Zhang D, Inuzuka H, Chen L, Chen H, Xie L, Kaniskan HÜ, Chen X, Jin J, Wei W.   +11 more
europepmc   +1 more source

A nanobiotechnological approach to control non‐persistent aphid‐transmitted plant viruses, based on functionalized virus‐like particles

Annals of Applied Biology, Volume 189, Issue 3, November 2026.
A potyvirus‐derived virus‐like nanoparticle (VLP) interferes in the transmission by aphids of the non‐circulative plant viruses turnip mosaic virus (TuMV, Potyvirus), zucchini yellow mosaic virus (ZYMV, Potyvirus), and cucumber mosaic virus (CMV, Cucumovirus) is also observed. The construct, that consisted of a fusion between a modified TuMV HC‐Pro and
Aranzazu Moreno, Inmaculada Ferriol, Lucia Zurita, Maria Plaza, Rocio Galán‐Cubero, Adriana Urbano‐Bernabé, Alberto Fereres, Fernando Ponz   +7 more
wiley   +1 more source

Dual FLT3/MAPK14 Proteolysis-Targeting Chimera (PROTAC) Induces Potent Acute Myeloid Leukemia Cell Death. [PDF]

Pharmaceuticals (Basel)
Abdelsalam M, Halilovic M, Ashry R, Nassar H, Erdmann F, Schmidt M, Krämer OH, Sippl W.   +7 more
europepmc   +1 more source

Bridged Proteolysis Targeting Chimera (PROTAC) Enables Degradation of Undruggable Targets. [PDF]

J Am Chem Soc, 2022
Xiong Y, Zhong Y, Yim H, Yang X, Park KS, Xie L, Poulikakos PI, Han X, Xiong Y, Chen X, Liu J, Jin J.   +11 more
europepmc   +1 more source