Results 261 to 270 of about 13,195 (282)

Investigating the cell permeability of proteolysis-targeting chimeras (PROTACs)

Expert Opinion on Drug Discovery, 2023
Hidetomo Yokoo, Mikihiko Naito, Yosuke Demizu   +2 more
openaire   +2 more sources

The Potential of Proteolysis-Targeting Chimeras for Weed Control

Outlooks on Pest Management
New tools are critically needed to diversify weed control in many crops and to combat herbicide resistant weeds. PROteolysis-TArgeting Chimera (PROTAC) is a new molecular technique that consists of using an organic molecule designed to interact with a target protein and to recruit an E3 ligase.
openaire   +1 more source

Proteolysis Targeting Chimera (PROTAC) for Macrophage Migration Inhibitory Factor (MIF) Has Anti‐Proliferative Activity in Lung Cancer Cells

Angewandte Chemie - International Edition, 2021
Zhangping Xiao, Shanshan Song, Deng Chen   +2 more
exaly  

Proteolysis-Targeting Chimeras: A Kaleidoscope of Targeted Protein Degradation

Future Medicinal Chemistry, 2021
Yi Mou, Shuai Wen, Xinxing Gao, Zheng-Yu Jiang   +3 more
openaire   +2 more sources

Oral lipid nanocomplex of BRD4 PROteolysis TArgeting Chimera and vemurafenib for drug-resistant malignant melanoma

Biomedicine and Pharmacotherapy, 2023
Rehab Hegazy, Yige Fu, Blase Billack
exaly  

Discovery of potent epidermal growth factor receptor (EGFR) degraders by proteolysis targeting chimera (PROTAC)

European Journal of Medicinal Chemistry, 2020
Hao Zhang, Hong-Yi Zhao, Minhang Xin
exaly  

Susceptibility of Lung Carcinoma Cells to Nanostructured Lipid Carrier of ARV-825, a BRD4 Degrading Proteolysis Targeting Chimera

Pharmaceutical Research, 2022
Zhe-Sheng Chen, Ketan Patel
exaly  

Selective degradation of histone deacetylase 8 mediated by a proteolysis targeting chimera (PROTAC)

Chemical Communications, 2022
Yasunobu Yamashita, Yuri Takada, Makoto Oba   +2 more
exaly  

Induced protein degradation of histone deacetylases 3 (HDAC3) by proteolysis targeting chimera (PROTAC)

European Journal of Medicinal Chemistry, 2020
Fangyuan Cao, Deng Chen, Robert P Coppes   +2 more
exaly  

Proteolysis targeting chimeras of Anaplastic lymphoma kinase

2020
Anaplastic lymphoma kinase (ALK)-positive Anaplastic Large Cell Lymphoma (ALCL) is a disease most commonly found in children and young adults (median age 34) with a slight male dominance. This cancer infects mainly lymph nodes, nevertheless it can be involved in other site than the lymph like the skin, soft tissues and bones.
openaire   +1 more source