Results 141 to 150 of about 183,121 (297)

Effect of Acidulants and Milk-Clotting Enzymes on Yield, Sensory Quality, and Proteolysis of Pizza Cheese Made by Direct Acidification

, 1968
E.L. Quarne, W.A. Larson, N.F. Olson
openalex   +1 more source

A Super‐Enhancer‐Driven Transcriptional Regulatory Circuit Underlying Abiraterone Resistance in Castration‐Resistant Prostate Cancer

Advanced Science, EarlyView.
This study identifies a super‐enhancer‐driven transcriptional regulatory circuit comprising BCL6, SMAD3, and NFIB that cooperate to drive cholesterol synthesis via SREBF2/HMGCR/FDFT1 activation and regulate CDK2/CCND3 for cell cycle control. Targeting this circuit with BI‐3802 or downstream inhibitors (Fatostatin/Lovastatin) overcomes abiraterone ...
Liling Jiang, Jiamin Wang, Guanjie Peng, Haichuan Zhang, Jinxin Fang, Yingyin Gao, Enzhe Lou, Yangzhou Liu, Wa Ding, Bingyuan Liu, Qiong Mao, Lizhen Jiang, Aochu Liu, Xinyue Li, Shiwen Hu, Qiaomin Ma, Yueyuan Zheng, Zhigang Zhao, Xianping Shi   +18 more
wiley   +1 more source

Editorial: Post-translational modifications of extracellular signaling molecules and antigens in immune and inflammatory responses

Frontiers in Immunology, 2022
Inna S. Afonina, Inna S. Afonina, Loredana Frasca, Gaby Palmer, Gaby Palmer   +4 more
doaj   +1 more source

RPL6 Interacts with HMGCS1 to Stabilize HIF‐1α by Promoting Cholesterol Production in Hepatocellular Carcinoma

Advanced Science, EarlyView.
The study found that RPL6 is frequently upregulated in HCC tissues with extrahepatic metastasis. Elevated RPL6 bound to and increased the stability of HMGCS1 mRNA, thereby enhancing intracellular cholesterol levels. Subsequently, increased cholesterol promotes cancer metastasis in HCC by stabilizing HIF‐1α protein.
Minli Yang, Shengtao Cheng, Huiying Gu, Shan Zhong, Dapeng Zhang, Xin He, Weixian Chen, Haijun Deng, Jihua Ren, Peng Chen, Ming Tan, Hui Zhang, Fan Li, Zhenzhen Zhang, Yuan Hu, Juan Chen   +15 more
wiley   +1 more source

Effects of Proteolysis of Natural Cheese on Body and Melting Properties of Pasteurized Process Cheese Spread

, 1962
D.G. Vakaleris, N.F. Olson, Walter V. Price   +2 more
openalex   +1 more source

Remodeling the Physicochemical and Pharmacokinetic Properties of PROTAC via Lipid Nanodisks for Cancer Therapy

Advanced Science, EarlyView.
To solve the challenge of PROTACs in clinical potential due to poor water solubility and membrane permeability, a nanodelivery system based on lipid nanodisks loaded with MZ1 prodrug (LND‐MZ1) to remodel the physicochemical and pharmacokinetic properties of PROTAC MZ1 is elaborately proposed.
Meichen Pan, Chunrong Yang, Zhongliang Fu, Yuchen Yang, Ying Zhuo, Hongwei Hou, Jinghong Li   +6 more
wiley   +1 more source

Neprilysin 2 catalyses the degradation of natriuretic peptides despite sacubitrilat Inhibition. [PDF]

Sci Rep
Selezneva EM, Feygina EE, Ageeva LV, Rozov FN, Kopylova IV, Altshuler EP, Semenov AG.   +6 more
europepmc   +1 more source

Human Schlafen 14 Cleavage of Short Double‐Stranded RNAs Underpins its Antiviral Activity

Advanced Science, EarlyView.
SLFN14 is associated with human diseases. SLFN14 is found to cleave RNAs containing short duplexes. The cryo‐EM structures of SLFN14 and SLFN14‐hairpin RNA complex reveal that SLFN14 assembles into a ring‐like dimer; two RNase domains form an RNA‐binding groove accommodating a hairpin RNA.
Mengyun Li, Dapeng Sun, Wei Hao, Hua Fu, Yueli Zhang, Zhijian Li, Bo Qin, Yumei Wang, Sheng Cui   +8 more
wiley   +1 more source

The dual ubiquitin binding mode of SPRTN secures rapid spatiotemporal proteolysis of DNA-protein crosslinks. [PDF]

Nucleic Acids Res
Song W, Zhao Y, Ruggiano A, Redfield C, Newman JA, Zhu X, García-Flores M, Cruz-Migoni A, Roddan R, Pérez-Ràfols A, McHugh PJ, Elliott PR, Ramadan K.   +12 more
europepmc   +1 more source

Sequence of Fibrinogen Proteolysis and Platelet Release after Intrauterine Infusion of Hypertonic Saline [PDF]

, 1979
H. L. Nossel, J. Wasser, Karen L. Kaplan, K S LaGamma, I. Yudelman, R E Canfield   +5 more
openalex   +1 more source