Results 151 to 160 of about 278,197 (298)

Glucose and Glutamine Deprivation Promotes Breast Cancer Lung Metastasis via BRD4‐Dependent Enhancer Activation

Advanced Science, EarlyView.
To model a nutrient‐restricted tumor microenvironment, breast cancer cells were adapted to low glucose and glutamine levels. In the adapted cells, BRD4‐driven enhancer activation increases pro‐invasive EDN1 expression, facilitated by ATF3/c‐JUN and reinforced by enhancer RNA.
Poshan Yugal Bhattarai, Arathy Vasukutty, Yujin Na, Sung‐Chul Lim, Hong Seok Choi   +4 more
wiley   +1 more source

Purification of Eel Liver Glutamate Dehydrogenase Suffered Limited Proteolysis

Glutamate dehydrogenase (GDH) suffered limited proteolysis was purified from the acetone powder of the eel liver. Limited proteolysis of GDH occurred at heat treatment in purification procedures, but it was inhibited by leupeptin, an inhibitor of trypsin
TANG, Min Qian, 福山, 恵子, HAYASHI, Seiichi, FUKUYAMA, Keiko, 大城, 善太郎, 湯, 敏謙, MORSHED, Monzoor, OOSHIRO, Zentaro, 林, 征一   +8 more
core  

Calcium-dependent proteolysis of the chimeric androglobin reveals altered localization of its isolated globin domain. [PDF]

J Biol Chem
Koay TW, Osterhof C, Clerc A, Hoogewijs D.   +3 more
europepmc   +1 more source

Focus on proteolysis

The Plant Cell
Nancy A Eckardt, Pascal Genschik, Liwen Jiang, Xin Li, Marisa S Otegui, Ari Sadanandom, Steven H Spoel, Klaas J van Wijk, Dolf Weijers   +8 more
openaire   +2 more sources

DLST Succinylation‐Mediated Mitochondrial Metabolic Remodeling and Cuproptosis Resistance Promote Malignant Progression of Lung Adenocarcinoma

Advanced Science, EarlyView.
The DLST K409 succinylation mediated by CPT1A promotes OXPHOS and redox homeostasis through regulating enzyme activity, thereby promoting the malignant progression of LUAD. Notably, the succinylation of DLST can enhance the cuproptosis resistance by inhibiting its lipoylation.
Xuanxuan Li, Peijun Zhou, Xingzhi Peng, Qixin Liu, Wenhui Zeng, Rui Wang, Liangfang Shen, Jinwu Peng, Qin Zhou, Lifang Yang   +9 more
wiley   +1 more source

Global proteolysis during starvation governs proteome remodeling and a survival-regrowth trade-off in bacteria. [PDF]

Proc Natl Acad Sci U S A
Manzanarez G, Balakrishnan R, Kannan H, Abele M, Okano H, She F, Zhang Z, Wu C, Freiman L, Ludwig C, Mori M, Hwa T.   +11 more
europepmc   +1 more source

A Metal‐Polyphenol Self‐Assembled Coated 3D Sponge With Mild Photothermal Antibacterial, Exudate‐Controlling, and Immunomodulatory Functions for Hemostasis and Chronic Wound Healing

Advanced Science, EarlyView.
A thrombin‐functionalized copper‐polydopamine nanofiber sponge integrates rapid hemostasis, mild photothermal antibacterial therapy, stimulus‐responsive Cu2+ release, chemodynamic oxidative stress, and macrophage immunomodulation. This multifunctional dressing suppresses infection, regulates inflammation, promotes angiogenesis and re‐epithelialization,
Ziwei Zhang, Feng Qin, Xiaomeng Zhang, Xueqin Shuang, Jiahua Zhou, Ming Cheng, Baicheng Lu, Mingyue Song, Yuntian Bai, Dianying Zhang, Ming Li, Yanhua Wang   +11 more
wiley   +1 more source

TECTB Variants Reveal Tectorial Membrane Vulnerability in Dominant Non‐Syndromic Hearing Loss

Advanced Science, EarlyView.
TECTB is a non‐collagenous protein of the tectorial membrane – an extracellular matrix of the cochlea. This study identifies dominant missense variants in TECTB linked to human hereditary deafness in two unrelated families. Genetically engineered mice homozygous for one of the variants are profoundly deaf, whereas heterozygous mice have normal hearing ...
Evan B. Hale, Barbara Vona, Richard J. Goodyear, Richard T. Osgood, Jun Shen, Sami S. Amr, Karen Mojica, Michaela A. H. Hofrichter, Jörg Schröder, Sophie Flandin, Paul Gratias, Ricardo Vera‐Monroy, Katherine Callahan, Kerry L. Gudlewski, Rolen Quadros, Masato Ohtsuka, JoAnn McGee, Edward J. Walsh, Cynthia C. Morton, Thomas Haaf, Channabasavaiah Gurumurthy, James E. Saunders, Guy P. Richardson, Artur A. Indzhykulian   +23 more
wiley   +1 more source

Regulation of proteolysis by specialised adaptor proteins

Regulation of proteolysis by specialised adaptor proteins. Training research scientists of the future forms an integral part of this research program and this collaboration will provide an excellent opportunity for young Australian scientists to be ...

core  

Microbial Proteases as Product-Directed Catalysts for Industrial Proteolysis. [PDF]

Biomolecules
Han SW.
europepmc   +1 more source