Results 181 to 190 of about 390,280 (339)

Controllable endogenic proteolysis as a major factor of switching tryptophanyl-tRNA synthetase from canonical aminoacylation activity to non-canonical regulatory functions

, 2014
М. К. Нурбеков, A. A Elov, R. I Zhdanov   +2 more
openalex   +2 more sources

HSP70 Interactome‐Mediated Proteolysis Targeting Chimera (HSP70‐PROTAC) for Ferroptosis‐Driven Cancer Treatment

Advanced Science, EarlyView.
This study reports a novel targeted protein degradation strategy termed “HSP70‐PROTAC” that recruits Hsc70 complex to a target protein for inducing degradation. Among them, GDAz‐3 exhibits effective GPX4 degradation activity via UPS/CMA processes, triggering ferroptosis‐driven anticancer activity in vitro and in vivo.
Jinyun Dong, Yulong Li, Hui Liang, Zumei Wu, Shiqun Wang, Yichao Wang, Jieyu Xu, Yanning Lan, Maohua Cai, Guangzhao Pan, Haiyan Yang, Kai Miao, Zhe‐Sheng Chen, Fangfang Tao, Xuelei Ma, Jiang‐Jiang Qin   +15 more
wiley   +1 more source

Pepsin Digestion for Proteomic Studies of the Human Hair Shaft. [PDF]

Rapid Commun Mass Spectrom
Yee DH, Mukhtarov R, Sharma AD, Lin C, Sun B.   +4 more
europepmc   +1 more source

Proteolysis in tumours [PDF]

Biochemical Journal, 1932
openaire   +2 more sources

Engineered GM1 Intersects Between Mitochondrial and Synaptic Pathways to Ameliorate ALS Pathology

Advanced Science, EarlyView.
Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease driven by genetic and molecular disruptions affecting energy balance, protein homeostasis, and stress responses in nerve cells. Studies using human and rodent models identified convergent defects in mitochondria and synaptic function.
Federica Pilotto, Tristan Dellazizzo Toth, Silvano Bond, Alexander Schmitz, Rim Diab, Sara Y. Ngo Tenlep, Brian Mooney, Silvia Erni, Martina Schobesberger, Olivier Scheidegger, Camille Peitsch, Smita Saxena   +11 more
wiley   +1 more source

Editorial: Proteases of the prokaryotic cell envelope

Frontiers in Microbiology, 2022
Rosana E. De Castro, Ansgar Poetsch, Ansgar Poetsch, Ansgar Poetsch   +3 more
doaj   +1 more source

Correction: Proteolysis targeting chimeras (PROTACs) come of age: entering the third decade of targeted protein degradation. [PDF]

RSC Chem Biol
Bond MJ, Crews CM.
europepmc   +1 more source

Regulation of SOS mutagenesis by proteolysis.

, 1996
Ekaterina G. Frank, Don G. Ennis, Martín Gonzalez, C. Elizabeth Shaaban, Roger Woodgate   +4 more
openalex   +2 more sources

Evolutionary Divergence of an Ethylene‐Responsive Transcriptional Cascade Governs a Dose‐Dependent Balance between Cotton Fiber Length and Strength

Advanced Science, EarlyView.
A tunable, ethylene‐responsive cascade governing the dose‐dependent balance between fiber length and strength is unveiled. Elevated ethylene strengthens modern tetraploid cotton (G. hirsutum) fibers but elongates those of its diploid ancestor (G. arboreum). This phenotypic switch is traced to an evolutionary functional inversion of a conserved EIN3‐ERF‐
Jie Zhang, Mengli Yu, Yuling Guo, Jie Li, Gailing Gu, Ghulam Hussain, Shuya Ma, Fuguang Li, Hongwei Xue, Zhaoen Yang, Zuoren Yang   +10 more
wiley   +1 more source

Rapid and Label-Free Structural Proteomics Using One-Step Swift Trypsin LiP-MS. [PDF]

ACS Omega
Miyashita Y, Konno R, Ogasawara S, Okuda Y, Takamuku Y, Moriya T, Saito T, Murata T, Ohara O, Kawashima Y.   +9 more
europepmc   +1 more source