Results 201 to 210 of about 183,121 (297)

Proteolysis of Extracellular Matrix in Human Disease 2.0. [PDF]

Int J Mol Sci
Yamashita H.
europepmc   +1 more source

“Disaggregation” of Phytochrome in Vitro—A Consequence of Proteolysis

, 1971
Gary Gardner, Carl S. Pike, Harbert V. Rice, Winslow R. Briggs   +3 more
openalex   +2 more sources

Molecular weight heterogeneity of tropoelastin resulting from proteolysis during preparation [PDF]

, 1974
A. Sampath Narayanan, Roy C. Page
openalex   +1 more source

Mortalin and PINK1/Parkin‐Mediated Mitophagy Represent Ovarian Cancer‐Selective Targets for Drug Development

Advanced Science, EarlyView.
Ovarian cancer patients with high levels of mortalin protein in their tumors have worse survival. The investigational drug SHetA2 interferes with mortalin's support of mitochondria. The resulting mitochondrial damage causes a process called mitophagy that contributes to how SHetA2 kills cancer cells. Noncancerous cells repair their mitochondria through
Vishal Chandra, Justin Garland, Rajani Rai, Donghua Zhao, Charuksha Walgama, Sadagopan Krishnan, Andrew T. Long, Tongzu Liu, Laura Adhikari, Doris M. Benbrook   +9 more
wiley   +1 more source

Mutations in PSEN1 predispose inflammation in an astrocyte model of familial Alzheimer's disease through disrupted regulated intramembrane proteolysis. [PDF]

Mol Neurodegener
Ziff OJ, Parfitt GM, Jolly S, Casey JM, Granat L, Samra S, Setó-Salvia N, Alatza A, Phadke L, Galet B, Ravassard P, Potier MC, Hardy J, Salih DA, Whiting P, Ducotterd F, Patani R, Wray S, Arber C.   +18 more
europepmc   +1 more source

Study of the thermal denaturation of ribonuclease A by differential thermal analysis and susceptibility to proteolysis [PDF]

, 1970
Bryan Winchester, A. P. Mathias, B. R. Rabin   +2 more
openalex   +1 more source

CGRP‐Loaded ROS‐Responsive Hydrogel Restores Neuro‐Angiogenic Signaling to Promote Bone Regeneration in Diabetes‐Associated Periodontitis

Advanced Science, EarlyView.
This study shows that diabetes damages sensory nerve fibers, especially CGRP‐positive ones, in the periodontium and disrupts autophagy in trigeminal ganglion neurons, affecting bone homeostasis by inhibiting type H vessel formation. To address this, CGRP@PVA/tsPBA hydrogels are developed to release CGRP in response to ROS, which binds to endothelial ...
Chaoning Zhan, Qingyi Dai, Jianhan Ren, Lijian Jin, Weiping Wang, Zhou Ye, James Kit Hon Tsoi, Yifan Lin   +7 more
wiley   +1 more source

Development of a Thiol-ene Microfluidic Chip for Hydrogen/Deuterium Exchange Mass Spectrometry (HDX-MS). [PDF]

Anal Chem
Hansen AB, Svejdal RR, Aerts JT, Stahlhut VBP, Harmash D, Hamidi M, Sticker D, Kutter JP, Rand KD.   +8 more
europepmc   +1 more source

Size and Configuration of Glycoprotein Fragments Cleaved from Tumor Cells by Proteolysis

, 1973
Henry S. Slayter, John F. Codington
openalex   +1 more source

Akkermansia muciniphila‐Derived N‐Acetylspermidine Modulates the Localization of Intestinal α1,2‐Fucosylated Proteins to Maintain Gut Homeostasis

Advanced Science, EarlyView.
This study demonstrates that Akkermansia muciniphila alleviates colitis by enhancing intestinal α1,2‐fucosylation through its metabolite N‐acetylspermidine. Mechanistically, N‐acetylspermidine‐induced PIM1 inhibition promotes HDAC2‐mediated reduction of chromatin accessibility at TP73, thereby upregulating C1GALT1C1 to boost α1,2‐fucosylation.
Ye Yao, Zhangming Pei, Yuanyuan Dai, Yinghan Chen, Zepeng Chang, Hongchao Wang, Jianxin Zhao, Hao Zhang, Qixiao Zhai, Wenwei Lu, Wei Chen   +10 more
wiley   +1 more source