Results 211 to 220 of about 278,197 (298)

Caspase-mediated cleavage events hidden by secondary proteolysis during apoptosis. [PDF]

Protein Sci
Fotouhi F, Gomez-Cardona E, Patel J, Julien O, Fearnhead H.   +4 more
europepmc   +1 more source

H4K12 Lactylation Regulates NDUFS7 to Drive Microglia Reverse Electron Transport in Spinal Cord Injury

Advanced Science, EarlyView.
Lactate accumulation after SCI promotes H4K12la lactylation, which upregulates NDUFS7, triggering mitochondrial RET and ROS, enforcing pro‐inflammatory microglial polarization. MM@mPTC, a biomimetic nanotherapeutic, degrades LDHA in activated microglia, reducing H4K12la lactylation and blocking RET, thus curbing ROS, fostering a reparative phenotype ...
Chenglong Hong, Zhichen Jiang, Zhouwei Wu, Chenyu Wu, Jiang Liu, Kaijie Guo, Yihui Liang, Shaobo Xu, Yuchen Jin, Yong Xiao, Lei Guo, Hui Xu, Sunren Sheng, Chenggui Wang   +13 more
wiley   +1 more source

Meprin proteases in cutaneous homeostasis and psoriasis: pathophysiological mechanisms and therapeutic prospects. [PDF]

Front Immunol
Pillai V, Rasool M.
europepmc   +1 more source

Decoding Biomolecular Phase Separation: From Physiological Roles to Pathological Mechanisms and Therapeutic Biomaterials Design

Advanced Science, EarlyView.
This review systematically elaborates on the mechanisms underlying physiological regulation and pathological dysregulation of biomolecular phase separation. It also summarizes advances in phase‑separation‑targeted therapeutic strategies and the design of functional biomaterials inspired by this process.
Jiawei Zhu, Jingbo Dong, Qiufang Gong, Xuejiao Song, Zhifa Shen, Chao Liang   +5 more
wiley   +1 more source

Conformational bias in SARS-CoV-2 Spike CD4+ T-cell epitope dominance. [PDF]

Front Immunol
Landry SJ, Steede NK, Tiomkin Y, Smith H, Mettu RR, Gragert L, Aberle JH, Zwezdaryk KJ, Zheng C, Kolls JK, Gunn BM, Murrell AE, Trinh IV, Schieffelin JS, Robinson JE, Norton EB.   +15 more
europepmc   +1 more source

Mechanically Regulated Secretion: How Physical Forces Instruct the Secretory Pathway and Remodel the Secretome

Advanced Science, EarlyView.
Mechanical cues, including ECM stiffness, stretch, compression, shear stress, and traction forces, remodel trafficking across the secretory pathway, from the ER and Golgi to endolysosomal compartments and the plasma membrane. The resulting secretome reshapes ECM composition and tissue mechanics, establishing feedback loops that support homeostasis or ...
Domenico Russo, Seetharaman Parashuraman, Maria Luigia Maresca, Angela Francesca Dinoi, Alessia Calcagnì, Riccardo Rizzo   +5 more
wiley   +1 more source

Systemic impact of intramuscular snake envenomation and intravenous immunoglobulin-based antivenom treatment on murine plasma proteome and peptidome. [PDF]

Protein Sci
de Barros BCSC, Chaves AFA, Morone MSLC, Sachetto ATA, Santoro ML, Schilling O, Serrano SMT.   +6 more
europepmc   +1 more source

Intermittent Fasting Reduces Taurine Availability and Promotes Antitumor Immunity Through PERK Attenuation‐Associated Paraptosis‐Like Cell Death in Colorectal Cancer

Advanced Science, EarlyView.
This study identifies reduced taurine availability as a mediator of intermittent fasting in colorectal cancer and shows that taurine interacts with GRP78 to maintain PERK abundance post‐transcriptionally. It further shows that taurine depletion destabilizes PERK, induces immunogenic paraptosis, remodels the tumor microenvironment toward a CD8+ T cell ...
Baohui Song, Sikei Kam, Jingyi Liu, Rui Lv, Xucheng Huo, Zhanghan Chen, Yuelun Dong, Shilun Cai, Bing Li, Ruobing Ren, Yunshi Zhong, Mingyan Cai   +11 more
wiley   +1 more source

Amidine isosteric modification tunes proteolytic stability and activity. [PDF]

RSC Chem Biol
Byerly-Duke J, Bernhard SM, Ibrahim R, Das S, Sharma KK, Panda C, Venditti V, Che T, VanVeller B.   +8 more
europepmc   +1 more source