<i>Lactobacillus delbrueckii</i>: A Functional Powerhouse in Dairy Fermentation and Emerging Probiotic Applications. [PDF]
Nami Y +4 more
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Correction to "DNA-Programmable Protein Degradation: Dynamic Control of Proteolysis-Targeting Chimera Activity via DNA Hybridization and Strand Displacement". [PDF]
Kashyap D, Haider S, Milne TA, Booth MJ.
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Enzymatic Tenderization of Garden Snail Meat (<i>Cornu aspersum aspersum</i>) Using Plant Cysteine Proteases. [PDF]
Tesarowicz I +6 more
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A highly potent and broadly accessible bispecific nanobody for the treatment of ebola virus infections. [PDF]
Bu F +9 more
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Peptidomic profiling and molecular dynamics study of bioactive peptides from fermented camel milk: considering the fermentation time dependent proteolysis by <i>Lactobacillus</i> and <i>Saccharomyces</i> with antidiabetic, antioxidative and anti-inflammatory activities. [PDF]
Padhiyar PN +9 more
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Above-Filter Digestion Proteomics Reveals Drug Targets and Localizes Ligand Binding Site. [PDF]
Sokolova B +7 more
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Mitochondrial ClpP-Mediated Proteolysis Induces Selective Cancer Cell Lethality
The mitochondrial caseinolytic protease P (ClpP) plays a central role in mitochondrial protein quality control by degrading misfolded proteins. Using genetic and chemical approaches, we showed that hyperactivation of the protease selectively kills cancer
Jo Ishizawa, R Eric Davis, Ondrej Halgas
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Unraveling the Role of Linker Design in Proteolysis Targeting Chimeras.
Journal of Medicinal Chemistry, 2021A current bottleneck in the development of proteolysis targeting chimeras (PROTACs) is the empirical nature of linker length structure-activity relationships (SARs). A multidisciplinary approach to alleviate the bottleneck is detailed here.
Troy A Bemis, J. L. La Clair, M. Burkart
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