Results 291 to 300 of about 390,280 (339)

A high-resolution analysis of arrestin2 interactions responsible for CCR5 endocytosis. [PDF]

Elife
Petrovic I, Desai S, Isaikina P, Abiko LA, Spang A, Grzesiek S.   +5 more
europepmc   +1 more source

Recombinant Human Neuregulin1‐β1 Significantly Reduces Schwannoma Growth in Mice

Annals of Neurology, EarlyView.
rhNRGβ1‐Replacement‐Therapy: Under physiological conditions, NRGβ1 is expressed on axons (in orange), where it activates ERBB2 receptors, facilitating successful nerve regeneration following injury. However, loss of NF2 leads to a reduction in NRGβ1‐expression and increased ErbB2 levels on Schwann cells (in green), which contributes to schwannoma ...
Julia P. Bischoff, Alexander Schulz, Christian Hagel, Robert Büttner, Michael Reuter, Waylan K. Bessler, D. Wade Clapp, Helen Morrison   +7 more
wiley   +1 more source

Self-resistance mechanism to acyldepsipeptide antibiotics in the <i>Streptomyces</i> producer. [PDF]

mBio
Thomy D, Reinhardt L, Liebhart E, Franz-Wachtel M, Maček B, Sass P, Brötz-Oesterhelt H.   +6 more
europepmc   +1 more source

Human Brain Contusions Contain Pathogenic Transmissible Species that Induce Progressive Cognitive Decline and Tau Pathology in Mice

Annals of Neurology, EarlyView.
Objective Traumatic brain injury (TBI) is an established risk factor for dementia, although the underlying mechanisms remain unclear. Our previous research demonstrated that a single severe TBI in wild‐type (WT) mice induces a prion‐like form of tau (tauTBI) that spreads throughout the brain, leading to memory deficits.
Gloria Vegliante, Francesca Pischiutta, Elena Restelli, Federico Moro, Maria Antonietta Chiaravalloti, Ilaria Raimondi, Ilaria Bertani, Ilaria Lisi, Eliana Sammali, Rosaria Pascente, Serena Scozzari, Laura Pasetto, Carly Douglas, Marco Locatelli, Fabrizio Ortolano, Valentina Bonetto, David J. Loane, Nino Stocchetti, Roberto Chiesa, Elisa R. Zanier   +19 more
wiley   +1 more source

Comparison of <i>in vitro</i> antioxidant activities of kefir, yogurt, and cheese produced from goat milk. [PDF]

Food Chem X
Uzkuç H, Sarıtaş S, Çelebi Uzkuç NM, Karagül Yüceer Y, Esatbeyoglu T.   +4 more
europepmc   +1 more source

Neurofilament Proteoforms in Amyotrophic Lateral Sclerosis Are Different in Cerebrospinal Fluid and Blood

Annals of Neurology, EarlyView.
We used targeted immunopurification‐mass spectrometry (IP‐MS) to characterize human neurofilament light chain (NfL) proteoforms across various compartments to assess their alterations in amyotrophic lateral sclerosis (ALS). NfL is truncated in cerebrospinal fluid (CSF) and blood in patients with sporadic ALS (sALS) and these proteoforms differ between ...
John B. Coulton, Yingxin He, Melissa M. Budelier, Nicolas Barthélemy, Margaret D. Ireland, Miwei Hu, Danielle Graham, Toby Ferguson, James D. Berry, Randall J. Bateman, Timothy M. Miller, Cindy V. Ly   +11 more
wiley   +1 more source

Recurrent acquisition of nuclease-protease pairs in antiviral immunity. [PDF]

Science
Tuck OT, Hu JJ, Lopez SC, Adler BA, O'Brien CE, Hsieh K, Meredith C, Loi KJ, Yoon PH, Doherty EE, Lahiri A, Doudna JA.   +11 more
europepmc   +1 more source

DNase1 RS1053874 Polymorphism is Associated with Early Neurological Recovery through NET Modulation and with Long‐Term Survival in Ischemic Stroke: A Prospective Cohort Study

Annals of Neurology, EarlyView.
Objective Immunothrombosis contributes to ischemic stroke pathophysiology through neutrophil extracellular trap (NET) formation, which promotes thrombus stabilization and microvascular dysfunction. DNase1 is the principal endonuclease responsible for NET degradation.
B. Díaz‐Benito, P. Calleja, L. Alzamora, A. Ruiz‐García, A. Martínez‐Salio, M. Muñoz‐García, F. Ostos, A. García‐Culebras, A. Moraga, M.A. Moro, I. Lizasoain   +10 more
wiley   +1 more source

Dry-Aged Beef: A Global Review of Meat Quality Traits, Microbiome Dynamics, Safety, and Sustainable Strategies. [PDF]

J Food Sci
Ribeiro AJ, Silva F, Teixeira P, Saraiva CM.   +3 more
europepmc   +1 more source