Results 191 to 200 of about 13,155 (273)

Cell Morphological Profiling Enables High-Throughput Screening for PROteolysis TArgeting Chimera (PROTAC) Phenotypic Signature. [PDF]

ACS Chem Biol, 2022
Trapotsi MA, Mouchet E, Williams G, Monteverde T, Juhani K, Turkki R, Miljković F, Martinsson A, Mervin L, Pryde KR, Müllers E, Barrett I, Engkvist O, Bender A, Moreau K.   +14 more
europepmc   +1 more source

Sensing and Reprogramming Surface Receptor Activation With Synthetic Transcriptional Circuits

Advanced Science, Volume 13, Issue 25, 4 May 2026.
A synthetic receptor‐signalling induced transcription (RESIT) circuit is designed based on receptor activation mediated split protease complementation and release of membrane‐tethered synthetic transcriptional modules. The RESIT system enables probing Ca2+ entry, receptor tyrosine kinase (RTK) activities and Ras activation, and reprogramming RTK ...
Fei Liu, Mei Yuan, Li‐Juan Tang, Fenglin Wang, Xia Chu, Jian‐Hui Jiang   +5 more
wiley   +1 more source

DNA-Templated Spatially Controlled Proteolysis Targeting Chimera for Cyclin D1-CDK4/6 Complex Protein Degradation. [PDF]

J Am Chem Soc
Zheng R, Prasad A, Satyabola D, Xu Y, Roy S, Yan Y, Šulc P, Yan H.   +7 more
europepmc   +1 more source

A proteolysis-targeting chimera molecule selectively degrades ENL and inhibits malignant gene expression and tumor growth. [PDF]

J Hematol Oncol, 2022
Li X, Yao Y, Wu F, Song Y.
europepmc   +1 more source

Ionomycin-activated calpain triggers apoptosis [PDF]

, 2002
Adams, Arthur, Bepler, Berridge, Berridge, Buki, Chai, Chen, Cheng, Chinnaiyan, Clem, Deveraux, Diaz, Eto, Farrow, Fujita, Furuya, Gabrijelcic-Geiger, Goping, Goyal, Grandgirard, Green, Gross, Hafner, Hengartner, Huang, Knepper-Nicolai, Kubbutat, Leist, Li, Liu, Matsumura, McGahon, Molinari, Murphy, Murphy, Nakagawa, O'Donovan, Pinton, Porn-Ares, Potter, Raff, Ray, Reed, Riedl, Roy, Ruiz-Vela, Saido, Salvesen, Sasaki, Smith, Squier, Srinivasula, Stennicke, Stoka, Strack, Suzuki, Thompson, Thornberry, Varghese, Wang, Waterhouse, Wolf, Xie, Yin, Youn, Zamzami   +66 more
core   +2 more sources

G4‐Ligand‐Directed PROTACs Unveil DR1 as a Novel Ligand‐Co‐Binding G4‐Protein and Reshape G4‐Dependent Transcription

Advanced Science, Volume 13, Issue 27, 13 May 2026.
G4‐binding proteins (G4BPs) that specifically co‐bind G4s in the presence of small‐molecule ligands represent a critical but unexplored class of proteins. We introduce G4‐Ligand‐Directed PROTACs (G4L‐TACs), a chemical platform that couples G4 ligands (PDS) to E3 recruiters to selectively degrade these ligand‐co‐binding G4BPs.
Mao‐Lin Li, Shu‐Min Xu, Xin‐Chen Jiang, Le‐Tian Dai, Yu‐Tao Hu, Kai‐Bo Wang, Jia‐Heng Tan, Zhi‐Shu Huang, Shuo‐Bin Chen   +8 more
wiley   +1 more source

Identification of a Proteolysis-Targeting-Chimera that Addresses Activated Checkpoint Kinase-1 Reveals its Non-Catalytic Functions in Tumor Cells. [PDF]

Angew Chem Int Ed Engl
Ashry R, Abdelsalam M, Hausen J, Hieber C, Zeyn Y, Sarnow AC, Schmidt M, Najafi S, Oehme I, Bros M, Chen JX, Dejung M, Sippl W, Krämer OH.   +13 more
europepmc   +1 more source

Proteolysis targeting chimera technology: a novel strategy for treating diseases of the central nervous system. [PDF]

Neural Regen Res, 2021
Ma K, Han XX, Yang XM, Zhou SL.
europepmc   +1 more source

Cucurbit[7]uril‐Based Plug‐and‐Play Platform on Bacterial Surfaces for Constructing Functional Supramolecular Biohybrids

Aggregate, Volume 7, Issue 5, May 2026.
This study establishes a supramolecular “plug‐and‐play” platform on bacterial surfaces via cucurbit[7]uril host–guest chemistry. The platform successfully generates functional biohybrids for fluorescence imaging, drug delivery, and in vivo bioorthogonal catalysis, demonstrating its potential for functional living materials with broad biomedical ...
Fang Huang, Jun Zhu, Bingfa Wu, Xinyuan Sun, Linghong Huang, Yiliu Liu   +5 more
wiley   +1 more source

Correction to 'Proteolysis Targeting Chimera Loaded Extracellular Vesicles for Developing Triple Negative Breast Cancer Treatment'. [PDF]

J Extracell Vesicles
europepmc   +1 more source