Results 211 to 220 of about 13,155 (273)

Liver Fibrosis: Molecular Pathogenesis and Therapeutic Interventions

MedComm, Volume 7, Issue 5, May 2026.
We systematically summarized the etiologies, diagnostic approaches, and pathogenic mechanisms of liver fibrosis. Also, the therapeutic interventions for liver fibrosis were systematically classified into two main categories: etiological treatment and mechanism‐based antifibrotic therapies.
Jiaorong Qu, Wenqing Qin, Minghang Dong, Zhi Ma, Si Li, Runping Liu, Ranyun Chen, Changmeng Li, Xiaojiaoyang Li   +8 more
wiley   +1 more source

Rational Design and Optimization of a Potent IDO1 Proteolysis Targeting Chimera (PROTAC). [PDF]

J Med Chem
Monsen PJ, Bommi PV, Grigorescu AA, Lauing KL, Mao Y, Berardi P, Zhai L, Ojo O, Penco-Campillo M, Koch T, Egozi M, Jha S, Dunne SF, Jiang H, Song G, Zhang F, Kregel S, Vaziri-Gohar A, Fanning SW, Sanchez-Gomez P, Allen JM, Yamini B, Lukas RV, Wainwright DA, Schiltz GE.   +24 more
europepmc   +1 more source

Fusion Molecules Between the STAT5b Inhibitor Stafib‐2‐CR and a Cereblon Ligand

ChemistryOpen, Volume 15, Issue 5, May 2026.
The design and synthesis of fusion molecules between the selective STAT5b inhibitor Stafib‐2‐CR and a ligand of the E3 ubiquitin ligase cereblon is reported. Activity analysis in fluorescence polarization assays and isothermal titration calorimetry indicated that the chosen attachment point for the linker is well‐suited to retain activity of the fusion
Theresa Münzel, Karl Christian Seidenstücker, Christoph Protzel, Angela Berg, Thorsten Berg   +4 more
wiley   +1 more source

Preparation and Characterization of Ternary Complexes to Improve the Solubility and Dissolution Performance of a Proteolysis-Targeting Chimera Drug. [PDF]

Pharmaceutics
Zhang H, Wu H, Wang L, Galarza LM, Wu C, Li M, Wang Z, Zhou E, Han J.   +8 more
europepmc   +1 more source

L1CAM Promotes the Infiltrative Properties of Patient‐Derived Glioblastoma Cells

Cancer Science, Volume 117, Issue 5, Page 1380-1396, May 2026.
In vivo validation of L1CAM‐mediated GBM infiltration. Orthotopic transplantation of L1CAM‐expressing GBM cells into mouse brains demonstrated that L1CAM significantly promotes tumor cell infiltration and expansion in the brain parenchyma, confirming its critical role in the aggressive progression of GBM.
Asako Katsuma, Daisuke Kanematsu, Yukako Handa, Tomoko Shofuda, Atsuyo Yamamoto, Kayo Nishitani, Zhize Xiao, Daisuke Kawauchi, Kentarou Baba, Naoyuki Inagaki, Yonehiro Kanemura   +10 more
wiley   +1 more source

Preclinical Evaluation of Bavdegalutamide (ARV-110), a Novel PROteolysis TArgeting Chimera Androgen Receptor Degrader. [PDF]

Mol Cancer Ther
Snyder LB, Neklesa TK, Willard RR, Gordon DA, Pizzano J, Vitale N, Robling K, Dorso MA, Moghrabi W, Landrette S, Gedrich R, Lee SH, Taylor ICA, Houston JG.   +13 more
europepmc   +1 more source

Talquetamab: Mechanism of Action, Clinical, and Translational Science

Clinical and Translational Science, Volume 19, Issue 5, May 2026.
ABSTRACT Talquetamab is a first‐in‐class, T‐cell–redirecting bispecific antibody targeting GPRC5D, a novel antigen highly expressed on malignant plasma cells with limited expression in normal tissues. Despite advances in treatment, multiple myeloma (MM) remains incurable, and talquetamab offers a promising therapeutic option for patients with relapsed ...
Yibo Wang, Jue Gong, Nicholas Au, Jie Zhou, Dongfen Yuan, Jaszianne Tolbert, Guoqiang Zhang, Deeksha Vishwamitra, Jenny Zhang, Nahor Haddish‐Berhane, Indrajeet Singh   +10 more
wiley   +1 more source

AP‐1‐Targeting Decoy Oligonucleotides: Mechanisms and Therapeutic Potential as Modulators of Inflammatory Pathways

Journal of Cellular and Molecular Medicine, Volume 30, Issue 9, May 2026.
ABSTRACT Numerous cellular functions, such as apoptosis, proliferation, differentiation, survival, transformation and cell migration, are regulated by a crucial transcription factor called activator protein 1 (AP‐1). Growing evidence indicates that AP‐1 is involved in severe conditions like fibrosis, cancer, and organ damage, as well as inflammatory ...
Maryam Mahjoubin‐Tehran, Samaneh Rezaei, Vasily N. Sukhorukov, Amin Jalili, Prashant Kesharwani, Amirhossein Sahebkar   +5 more
wiley   +1 more source

Harnessing the SPOP E3 Ubiquitin Ligase via a Bridged Proteolysis Targeting Chimera (PROTAC) Strategy for Targeted Protein Degradation. [PDF]

J Med Chem
Deng Z, Catlett J, Lee Y, Wu Q, Xu Z, Xie L, Chen X, Xiong Y, Kaniskan HÜ, Jin J.   +9 more
europepmc   +1 more source

CTNNB1 Genetic Variation and Its Interaction With DLK1 in Type 2 Diabetes Mellitus

The FASEB Journal, Volume 40, Issue 8, 30 April 2026.
This graphical abstract illustrates the integrated study of CTNNB1 and DLK1 interaction in type 2 diabetes mellitus (T2DM). Combining bioinformatics, human genetic analysis, and HFD‐induced mouse models, it shows CTNNB1 and DLK1 synchronous downregulation in T2DM, the protective effect of CTNNB1 rs1798802 GG genotype, and cooperative colocalization of ...
Xiaoxue Gan, Yilinuer Adeerjiang, Min Xu, Xuan He, Sheng Jiang, Guoli Du   +5 more
wiley   +1 more source