Results 221 to 230 of about 13,155 (273)

Structure-guided design of a methyltransferase-like 3 (METTL3) proteolysis targeting chimera (PROTAC) incorporating an indole-nicotinamide chemotype. [PDF]

RSC Med Chem
Weldert AC, Frey AF, Krone MW, Krähe F, Kuhn H, Kersten C, Barthels F.   +6 more
europepmc   +1 more source

Discovery of the First Potent DYRK2 Proteolysis Targeting Chimera Degraders. [PDF]

ACS Med Chem Lett
Chen J, Zhu W, Zhang W, Tong Y, Xu F, Pang J.   +5 more
europepmc   +1 more source

A protein knockdown strategy to study the function of β-catenin in tumorigenesis [PDF]

core   +1 more source

Chemoproteomics-Enabled <i>De Novo</i> Proteolysis Targeting Chimera Discovery Platform Identifies a Metallothionein Degrader to Probe Its Role in Cancer. [PDF]

J Am Chem Soc
Racioppo B, Pechalrieu D, Abegg D, Dwyer B, Ramseier NT, Hu YS, Adibekian A.   +6 more
europepmc   +1 more source

Leveraging Dual-Ligase Recruitment to Enhance Protein Degradation via a Heterotrivalent Proteolysis Targeting Chimera. [PDF]

J Am Chem Soc
Bond AG, Muñoz I Ordoño M, Bisbach CM, Craigon C, Makukhin N, Caine EA, Nagala M, Urh M, Winter GE, Riching KM, Ciulli A.   +10 more
europepmc   +1 more source

Discovery of a peptide proteolysis-targeting chimera (PROTAC) drug of p300 for prostate cancer therapy. [PDF]

EBioMedicine
Zhang D, Ma B, Liu D, Wu W, Zhou T, Gao Y, Yang C, Jian Y, Fan Y, Qian Y, Ma J, Gao Y, Chen Y, Xu S, Li L.   +14 more
europepmc   +1 more source

Proteolysis Targeting Chimera Agents (PROTACs): New Hope for Overcoming the Resistance Mechanisms in Oncogene-Addicted Non-Small Cell Lung Cancer. [PDF]

Int J Mol Sci
Cordani N, Nova D, Sala L, Abbate MI, Colonese F, Cortinovis DL, Canova S.   +6 more
europepmc   +1 more source

Targeted Protein Degradation (TPD) for Immunotherapy: Understanding Proteolysis Targeting Chimera-Driven Ubiquitin-Proteasome Interactions. [PDF]

Bioconjug Chem
Kamaraj R, Ghosh S, Das S, Sen S, Kumar P, Majumdar M, Dasgupta R, Mukherjee S, Das S, Ghose I, Pavek P, Raja Karuppiah MP, Chuturgoon AA, Anand K.   +13 more
europepmc   +1 more source

Exploring Orodispersible Films Containing the Proteolysis Targeting Chimera ARV-110 in Hot Melt Extrusion and Solvent Casting Using Polyvinyl Alcohol. [PDF]

Pharmaceutics
Meloni V, Halstenberg L, Mareczek L, Lu J, Liang B, Gottschalk N, Mueller LK.   +6 more
europepmc   +1 more source

Structurally Specific Z-DNA Proteolysis Targeting Chimera Enables Targeted Degradation of Adenosine Deaminase Acting on RNA 1. [PDF]

J Am Chem Soc
Wang Z, Zhang D, Qiu X, Inuzuka H, Xiong Y, Liu J, Chen L, Chen H, Xie L, Kaniskan HÜ, Chen X, Jin J, Wei W.   +12 more
europepmc   +1 more source