Results 251 to 260 of about 13,155 (273)

Clinical application of proteolysis targeting chimeras

International Conference on Modern Medicine and Global Health (ICMMGH 2023), 2023
Jinfeng Gao, Chuhan Meng, Vivian FT Yuan
openaire   +1 more source

Harnessing Multiplexed Proteolysis-Targeting Chimera for Comprehensive Influenza A Virus Targeting

Journal of the American Chemical Society
Influenza A virus (IAV) remains a global health threat due to its high mutation rate and immune evasion. Current therapies, limited by single-target mechanisms and drug resistance, are insufficient. To address this, we developed a multiplexed PROTAC strategy that simultaneously targets and degrades multiple components of the viral ribonucleoprotein ...
Yang-Yang Liu, Cong Yu, Jing Li, Meng-Qian Zhang, Shuang Feng, Zhi-Quan Tian, Zhi-Gang Wang, Dai-Wen Pang, Shu-Lin Liu   +8 more
openaire   +2 more sources

Investigating the cell permeability of proteolysis-targeting chimeras (PROTACs)

Expert Opinion on Drug Discovery, 2023
Hidetomo Yokoo, Mikihiko Naito, Yosuke Demizu   +2 more
openaire   +2 more sources

Dual-targeting fluorous peptide proteolysis-targeting chimeras for cancer therapy

Journal of Controlled Release
Proteolysis-targeting chimeras (PROTACs) offer a powerful strategy for degrading disease-causing proteins. Simultaneous degradation of two oncogenic proteins by PROTACs can yield synergistic therapeutic effects. Here, we developed a dual-targeting fluorous peptide-based PROTAC (DFP-PROTAC) that leverages supramolecular self-assembly for cancer therapy.
Guangyu, Rong, Yuhan, Li, Fang, Zhu, Yiteng, Lu, Zhengwang, Sun, Jiaxu, Hong, Yiyun, Cheng   +6 more
openaire   +2 more sources

Proteolysis Targeting Chimera (PROTAC) for Macrophage Migration Inhibitory Factor (MIF) Has Anti‐Proliferative Activity in Lung Cancer Cells

Angewandte Chemie - International Edition, 2021
Zhangping Xiao, Shanshan Song, Deng Chen
exaly  

Oral lipid nanocomplex of BRD4 PROteolysis TArgeting Chimera and vemurafenib for drug-resistant malignant melanoma

Biomedicine and Pharmacotherapy, 2023
Yige Fu, Ketankumar Patel
exaly  

The Potential of Proteolysis-Targeting Chimeras for Weed Control

Outlooks on Pest Management
New tools are critically needed to diversify weed control in many crops and to combat herbicide resistant weeds. PROteolysis-TArgeting Chimera (PROTAC) is a new molecular technique that consists of using an organic molecule designed to interact with a target protein and to recruit an E3 ligase.
openaire   +1 more source

Discovery of potent epidermal growth factor receptor (EGFR) degraders by proteolysis targeting chimera (PROTAC)

European Journal of Medicinal Chemistry, 2020
Hao Zhang, Hong-Yi Zhao, Minhang Xin
exaly  

Susceptibility of Lung Carcinoma Cells to Nanostructured Lipid Carrier of ARV-825, a BRD4 Degrading Proteolysis Targeting Chimera

Pharmaceutical Research, 2022
Zhe-Sheng Chen, Ketankumar Patel
exaly  

Selective degradation of histone deacetylase 8 mediated by a proteolysis targeting chimera (PROTAC)

Chemical Communications, 2022
Yasunobu Yamashita, Yuri Takada, Makoto Oba   +2 more
exaly