Results 161 to 170 of about 195,001 (261)

Disease proteomics

Genomic Medicine, 2008
openaire   +4 more sources

Orbitrap Astral-based proteome and phosphoproteome analysis identifies candidate proteins associated with the phosphatidate phosphatase MoPah1 in Magnaporthe oryzae. [PDF]

Sci Rep
Zhao J, Yang L, Shi X, Zou X, Liu B, Wu Y, Zhang C, Xiang L.   +7 more
europepmc   +1 more source

Integrating Spatial Proteogenomics in Cancer Research

Advanced Science, EarlyView.
Xx xx. ABSTRACT Background: Spatial proteogenomics marks a paradigm shift in oncology by integrating molecular analysis with spatial information from both spatial proteomics and other data modalities (e.g., spatial transcriptomics), thereby unveiling tumor heterogeneity and dynamic changes in the microenvironment.
Yida Wang, Yang Wu, Feng Zhang, Parthiban Periasamy, Haiyue You, Denise Goh, Rachel Elizabeth Ann Fincham, Xin Ning, Danping Wu, Lu Liu, Ying Jiang, Zhiwen Qian, Joe Yeong, Yan Zhang   +13 more
wiley   +1 more source

Ensemble molecular mimicry correlates with antibody cross-reactivity in proteome-wide studies. [PDF]

Front Immunol
Wrabl JO, Beale J, Fortunato G, Monsalve AVDB, Hilser VJ.   +4 more
europepmc   +1 more source

A Guide for Spatial Omics Technologies: Innovation, Evaluation, and Application

Advanced Science, EarlyView.
This review presents a strategy‐centric framework for spatial omics technologies, organizing methods by how spatial information is experimentally encoded. It compares key performance trade‐offs across sequencing‐ and imaging‐based approaches, examines computational and practical limitations, and highlights biomedical applications. The analysis provides
Xiaofeng Wu, Weize Xu, Da Lin, Leqiang Sun, Jinxia Dai, Gang Cao   +5 more
wiley   +1 more source

Exosomal proteomics reveals fatty acid metabolism linked to gefitinib resistance in non-small cell lung cancer. [PDF]

Cell Biol Toxicol
Zhang Y, Zhu W, Zhu J, Hu R, Yang Y.
europepmc   +1 more source

Targeted Degradation of eEF2K by a Structure‐Guided PROTAC Strategy for the Treatment of Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
This study developed an eEF2K‐targeting PROTAC, A6, that efficiently degrades eEF2K in TNBC cells, inhibiting tumor growth in vitro and in vivo. To enhance tumor‐specific delivery, we engineered A6@ZIF‐8, a pH‐sensitive nanocarrier, which improved drug accumulation at tumor sites, offering a promising therapeutic strategy for TNBC through targeted ...
Shijun Cao, Changxin Zhong, Shilong Jiang, Yungui Li, Yang Xi, Mingxuan Xiao, Ting Jiang, Xiaoya Wan, Zonglin Chen, Xiaohui Yu, Yan Cheng   +10 more
wiley   +1 more source

Maintenance of cytoplasmic and membrane densities shapes cellular geometry in Escherichia coli. [PDF]

Nat Commun
Chure G, de Silva RT, Sharma R, Lanz MC, Cremer J.   +4 more
europepmc   +1 more source

Advancing Precision Nutrition Through Multimodal Data and Artificial Intelligence

Advanced Science, EarlyView.
Individual responses to food vary dramatically, challenging traditional dietary advice. This review explores how the unique genetic makeup, gut microbiome, and brain activity shape host metabolic health. We examine how artificial intelligence integrates these multimodal data to predict individualized dietary needs, moving beyond one‐size‐fits‐all ...
Yuanqing Fu, Ke Zhang, Zelei Miao, Gaoyi Yang, Yujing Huang, Ju‐Sheng Zheng   +5 more
wiley   +1 more source

UltraPlex-TMT: Expanding Isobaric Hyperplexing via Orthogonal Protease Cleavage. [PDF]

J Proteome Res
Roumeliotis TI, Sialana FJ, Ho J, Choudhary JS.   +3 more
europepmc   +1 more source