Results 161 to 170 of about 461,354 (348)

Proteomics [PDF]

Journal of Biomedicine and Biotechnology, 2010
Garcia, Benjamin A., Cooper, Helen J., Dorrestein, Pieter C., Tang, Kai, Ueberheide, Beatrix M.   +4 more
openaire   +2 more sources

LincNEAT1 Encoded‐NEAT1‐31 Promotes Phagocytosis by Directly Activating the Aurora‐A–PI3K–AKT Pathway

Advanced Science, EarlyView.
LincNEAT1 Encoded‐NEAT1‐31 micropeptide directly binds with Aurora‐A and enhanced AKT pathways to pormotes phagocytosis against multi cancer cells. Abstract Macrophages play vital roles in innate and adaptive immunity, and their essential functions are mediated by phagocytosis and antigen presentation.
Jie Li, Jing Zhang, Xixi Li, Xin Liu, Bo Zeng, Jiayue Luo, Huijin Wang, Hanbing Zhang, Xinya Gao   +8 more
wiley   +1 more source

The cysteine proteome

Free Radical Biology and Medicine, 2015
The cysteine (Cys) proteome is a major component of the adaptive interface between the genome and the exposome. The thiol moiety of Cys undergoes a range of biologic modifications enabling biological switching of structure and reactivity. These biological modifications include sulfenylation and disulfide formation, formation of higher oxidation states,
Joshua D. Chandler, Dean P. Jones, Young-Mi Go   +2 more
openaire   +3 more sources

ZNHIT3 Regulates Translation to Ensure Cell Lineage Differentiation in Mouse Preimplantation Development

Advanced Science, EarlyView.
Box C/D snoRNP complex regulates protein translation. This study identifies ZNHIT3 as a key component of the complex and ensures normal protein expression, including transcription factors orchestrating cell fate commitment, during early mouse embryogenesis.
Guanghui Yang, Qiliang Xin, Jurrien Dean
wiley   +1 more source

Meisoindigo Acts as a Molecular Glue to Target PKMYT1 for Degradation in Chronic Myeloid Leukemia Therapy

Advanced Science, EarlyView.
Meisoindigo targets PKMYT1 for degradation by acting as a molecular glue that enhances PKMYT1‐TRIM25 interaction, leading to K48‐linked ubiquitination and subsequent proteasomal degradation, thereby exerting therapeutic effects in chronic myeloid leukemia.
Zhao‐Xin Zhang, Shu‐Ying Li, Fang‐Fei Li, Qin‐Yan Shi, Cheng‐Yong Tan, Xiao‐Jing Wang, Mi Li, Yun‐Bao Liu, Jing Jin, Yong Li, Shi‐Shan Yu   +10 more
wiley   +1 more source

Tailoring a Functional Synthetic Microbial Community Alleviates Fusobacterium nucleatum‐infected Colorectal Cancer via Ecological Control

Advanced Science, EarlyView.
The bottom‐up strategy based on multiomics data is used for the SynCom design, and it successfully inhibited F. nucleatum growth and achieved stable colonization in vivo. In addition, it promoted tryptophan metabolism and secondary bile acid conversion, reduced lipid accumulation, relieved microbiome disorder, decreased inflammatory reaction, and ...
Zhongkun Zhou, Mengyue Yang, Hong Fang, Baizhuo Zhang, Yunhao Ma, Yongyuan Li, Yingjie Liu, Zeying Cheng, Yuanchun Zhao, Zhenzhen Si, Hongmei Zhu, Peng Chen   +11 more
wiley   +1 more source

A Quantitative Proteome Map of the Human Body

Cell, 2019
Determining protein levels in each tissue and how they compare with RNA levels is important for understanding human biology and disease as well as regulatory processes that control protein levels.
Lihua Jiang, Meng Wang, Shin Lin, Ruiqi Jian, Xiao Li, Joanne Chan, Guanlan Dong, Huaying Fang, Aaron E. Robinson, Michael P. Snyder, F. Aguet, Shankara K. Anand, K. Ardlie, S. Gabriel, G. Getz, Aaron P. Graubert, Kane Hadley, R. Handsaker, Katherine H. Huang, Seva Kashin, D. MacArthur, Samuel R. Meier, Jared L. Nedzel, Duyen Y. Nguyen, A. Segrè, E. Todres, Brunilda Balliu, A. Barbeira, A. Battle, Rodrigo Bonazzola, A. Brown, Christopher D. Brown, Stephane E. Castel, Don Conrad, D. Cotter, N. Cox, Sayantani Das, Olivia M. de Goede, E. Dermitzakis, B. Engelhardt, E. Eskin, Tiffany Y. Eulalio, N. Ferraro, Elise D. Flynn, L. Frésard, E. Gamazon, D. Garrido-Martín, Nicole R. Gay, R. Guigó, Andrew R. Hamel, Yuan He, Paul J. Hoffman, F. Hormozdiari, L. Hou, H. Im, Brian Jo, S. Kasela, Manolis Kellis, Sarah Kim-Hellmuth, Alan M. Kwong, T. Lappalainen, Xin Li, Yanyu Liang, S. Mangul, P. Mohammadi, S. Montgomery, Manuel Muñoz-Aguirre, Daniel C. Nachun, A. Nobel, Meritxell Oliva, YoSon Park, Yongjin P. Park, P. Parsana, F. Reverter, J. Rouhana, C. Sabatti, A. Saha, Andrew Skol, M. Stephens, B. Stranger, B. Strober, Nicole A. Teran, A. Viñuela, Gao Wang, Xiaoquan Wen, Fred A. Wright, Valentin Wucher, Yuxin Zou, Pedro G. Ferreira, Gen Li, Marta Melé, Esti Yeger-Lotem, M. Barcus, Debra Bradbury, Tanya Krubit, J. McLean, L. Qi, Karna L. Robinson, Nancy V. Roche, Anna M. Smith, L. Sobin, D. Tabor, Anita H. Undale, J. Bridge, L. Brigham, B. Foster, Bryan M. Gillard, R. Hasz, Marcus Hunter, Christopher Johns, Mark Johnson, E. Karasik, G. Kopen, W. F. Leinweber, Alisa McDonald, M. T. Moser, K. Myer, Kimberley D. Ramsey, Brian Roe, Saboor Shad, Jeffrey A. Thomas, Gary Walters, Michael Washington, Joseph Wheeler, S. Jewell, D. Rohrer, Dana R. Valley, D. Davis, D. Mash, P. Branton, Laura K. Barker, H. Gardiner, M. Mosavel, L. Siminoff, P. Flicek, M. Haeussler, Thomas Juettemann, W. Kent, Christopher M. Lee, Conner C. Powell, K. Rosenbloom, Magali Ruffier, Daniel Sheppard, K. Taylor, S. Trevanion, D. Zerbino, Nathan S. Abell, J. Akey, Lin Chen, Kathryn Demanelis, J. Doherty, A. Feinberg, K. Hansen, P. Hickey, F. Jasmine, R. Kaul, M. Kibriya, Jin Li, Qin Li, Sandra Linder, B. Pierce, L. Rizzardi, Kevin S. Smith, J. Stamatoyannopoulos, Hua Tang, Latarsha J. Carithers, P. Guan, S. Koester, A. Little, Helen M. Moore, C. Nierras, Abhi Rao, J. Vaught, S. Volpi   +173 more
semanticscholar   +1 more source

Isoquercitrin Alleviates Diabetic Nephropathy by Inhibiting STAT3 Phosphorylation and Dimerization

Advanced Science, EarlyView.
This study identified a natural compound, isoquercitrin, which significantly alleviated kidney inflammation and fibrosis by inhibiting STAT3 activity. Isoquercitrin forms a strong, noncovalent bond that directly binds to STAT3. Isoquercitrin binds to the pY+1 pocket of the SH2 domain of STAT3 via hydrogen bonding with Ser668, Gln635, and Gln633 ...
Chen Xuan, Donghui Chen, Shuangna Zhang, Chaofan Li, Qingyun Fang, Dinghua Chen, Jiabao Liu, Xin Jiang, Yingjie Zhang, Wanjun Shen, Guangyan Cai, Xiangmei Chen, Ping Li   +12 more
wiley   +1 more source

A protein sequence-based deep transfer learning framework for identifying human proteome-wide deubiquitinase-substrate interactions

Nature Communications
Protein ubiquitination regulates a wide range of cellular processes. The degree of protein ubiquitination is determined by the delicate balance between ubiquitin ligase (E3)-mediated ubiquitination and deubiquitinase (DUB)-mediated deubiquitination.
Yuan Liu, Dianke Li, Xin Zhang, Simin Xia, Yingjie Qu, Xinping Ling, Yang Li, Xiangren Kong, Lingqiang Zhang, Chun-Ping Cui, Dong Li   +10 more
doaj   +1 more source

Amino acid metabolism conflicts with protein diversity [PDF]

arXiv, 2014
The twenty protein coding amino acids are found in proteomes with different relative abundances. The most abundant amino acid, leucine, is nearly an order of magnitude more prevalent than the least abundant amino acid, cysteine. Amino acid metabolic costs differ similarly, constraining their incorporation into proteins.
arxiv