Results 251 to 260 of about 434,903 (321)

Chemical Approaches for Functionally Probing the Proteome [PDF]

, 2002
Doron C. Greenbaum, Amos Baruch, Linda Hayrapetian, Zsuzsanna Darula, Alma L. Burlingame, Katlin F. Medzihradszky, Matthew Bogyo   +6 more
openalex   +1 more source

Among-population proteomic differences in Schistocephalus solidus based on excretory/secretory and total body protein predictions. [PDF]

Parasit Vectors
Wang A, Bolnick DI.
europepmc   +1 more source

Identification of HLA-B27-Restricted Peptides from the Chlamydia trachomatis Proteome with Possible Relevance to HLA-B27-Associated Diseases

, 2001
Wolfgang Kuon, Hermann‐Georg Holzhütter, Heiner Appel, Martina Grolms, Simon Kollnberger, Alexander Traeder, Peter Henklein, Elisabeth H. Weiss, Andreas Thiel, Roland Lauster, Paul Bowness, Andreas Radbruch, Peter‐Michael Kloetzel, Joachim Sieper   +13 more
openalex   +1 more source

Bicyclic Selenenyl Sulfides with Tuned Bioreductive Step Rates Reveal Constraints for Probes Targeting Thioredoxin Reductase

Angewandte Chemie, EarlyView.
Thiol reductants activate dichalcogenide probes by a cascade of partly reversible steps. Careful dichalcogenide engineering can tune the rates of these steps separately, to aim at probes that are kinetically selective for specific oxidoreductases in live cells.
Lukas Zeisel, Lucas Dessen Weissenhorn, Karoline C. Scholzen, Andrea Madabeni, Laura Orian, Elias S. J. Arnér, Oliver Thorn‐Seshold   +6 more
wiley   +2 more sources

In-Depth Cell-Type-Specific Proteome Landscape of the Brain from Human Amyloid-β Overexpression Mouse Model. [PDF]

Adv Sci (Weinh)
Ryu T, Kim SY, Thuraisamy T, Shin J, Jang Y, Kam TI, Na CH.   +6 more
europepmc   +1 more source

Extracellular Vesicles in Calcium Oxalate Nephrolithiasis: Emerging Biomarkers and Therapeutic Potential

Advanced NanoBiomed Research, EarlyView.
Kidney stones cause significant pain and healthcare costs. Current prediction, diagnosis, and treatment options are limited. Extracellular vesicles (EVs), rich in proteins, lipids, and nucleic acids, offer a promising solution. This review explores the roles of EVs in kidney stone management, highlighting their potential as biomarkers and therapeutic ...
Wang Zhu, Xu Changzhi, Deng Qiong, Liang Hui   +3 more
wiley   +1 more source

Small Molecule‐Induced Alterations of Protein Polyubiquitination Revealed by Mass‐Spectrometric Ubiquitome Analysis

Angewandte Chemie, EarlyView.
To monitor small molecule‐induced changes in protein polyubiquitination in an unbiased manner, we employ enrichment through tandem ubiquitin binding entities coupled to LC‐MS/MS analysis (TUBE‐MS). By applying the workflow to PROTAC, p97‐ and deubiquitinase‐inhibitor treatment of cells, we demonstrate its broad applicability and reveal the induction of
Siska Führer, Kai Gallant, Farnusch Kaschani, Markus Kaiser, Petra Janning, Herbert Waldmann, Malte Gersch   +6 more
wiley   +2 more sources

Editorial: Exploring small molecule probes: advancements and applications in pharmacological research. [PDF]

Front Pharmacol
Yeh IJ.
europepmc   +1 more source

Progress in Biomimetic Microdevices for Anticancer Drug Screening and their Potential for Enhancing In Vivo Efficacy

Advanced NanoBiomed Research, EarlyView.
Biomimetic microdevices are redefining anticancer drug screening by mimicking complex tumor microenvironments. This review highlights advances in microfluidic systems, cell microarrays, and in vivo‐like models, offering new insights into drug efficacy prediction and personalized medicine. The development of effective anticancer drugs remains a critical
Ching‐Te Kuo, Yen‐Tzu Liao, Hsinyu Lee   +2 more
wiley   +1 more source

The Iron–Sulfur Cluster of Bacterioferritin‐Associated Ferredoxin (Bfd): a “Biological Fuse” that Prevents Oxidative Damage to Cells?

Angewandte Chemie, EarlyView.
When cellular iron is low, bacterioferritin (Bfr) releases its stored iron through a reductive process dependent on the [2Fe–2S] ferredoxin Bfd. Why accessing stored iron should depend on an iron‐requiring protein when iron is scarce is unclear. Here, we show that the Bfd [2Fe–2S] cluster is sensitive to oxidative stress, suggesting that it may act as ...
Justin M. Bradley, Aiden M. Carter, Zinnia Bugg, Simon C. Andrews, Nick E. Le Brun   +4 more
wiley   +2 more sources