Results 261 to 270 of about 538,471 (385)

Soft‐Drug‐Inspired MnSTF Nano‐Adjuvant for Safe and Synergistic cGAS–STING Activation in Tumor Immunotherapy

Advanced Science, EarlyView.
This study introduces MnSTF, a soft‐drug‐inspired nanoadjuvant that overcomes the systemic toxicity of STING agonists. Through Mn2+ coordination with an ENPP1 inhibitor, it enables safe cGAS‐STING activation, remodels the tumor immune microenvironment, and synergizes with radiotherapy or vaccines to elicit robust antitumor immunity.
Guangfei Sun, Jiancheng Pan, Rui Li, Ruoxi Li, Ziyan Liu, Jinhui Wu, Tingsheng Lin, Yiqiao Hu, Ahu Yuan   +8 more
wiley   +1 more source

Functional and druggability analysis of the SARS-CoV-2 proteome

, 2020
Claudio N. Cavasotto, Maximiliano Sánchez‐Lamas, Julián Maggini   +2 more
openalex   +2 more sources

The Human Omnibus of Targetable Pockets. [PDF]

J Cheminform
Carpenter KA, Altman RB.
europepmc   +1 more source

IL‐4/STAT6‐signaling Influences Local Inflammation and Regeneration Processes During Acute Pancreatitis and Promotes Fibrosis by a Direct Activation of Pancreatic Fibroblasts During Chronic Pancreatitis

Advanced Science, EarlyView.
IL‐4/IL‐13/STAT6 signaling plays a crucial for the suppression of pro‐inflammation during acute pancreatitis and supports acinar cell regeneration but has only minor impact on fibrogenesis during chronic form of the disease. IL‐4/IL‐13 induce the expression of certain collagens directly in pancreatic fibroblasts via STAT6 activation, whereas ...
ElSheikh H, Salvers A, Piesker J, Buchholz S, Lange R, Ameling S, Steil L, Hammer E, Homuth G, Völker U, Bröker BM, Weiss FU, Sendler M, Glaubitz J   +13 more
wiley   +1 more source

Disease proteomics

Genomic Medicine, 2008
openaire   +4 more sources

Author response: Genome concentration limits cell growth and modulates proteome composition in Escherichia coli

Jarno Mäkelä, Alexandros Papagiannakis, Wei-Hsiang Lin, Michael C. Lanz, Skye Glenn, Matthew P. Swaffer, Georgi K. Marinov, Jan M. Skotheim, Christine Jacobs‐Wagner   +8 more
openalex   +1 more source

Effect of resistance training and protein intake pattern on myofibrillar protein synthesis and proteome kinetics in older men in energy restriction

, 2018
C. H. Murphy, Mahalakshmi Shankaran, Tyler A. Churchward‐Venne, Cameron J. Mitchell, Nathan M. Kolar, Louise M. Burke, John A. Hawley, Amira Kassis, Leonidas G. Karagounis, Kelvin W. Li, Chelsea King, Marc K. Hellerstein, Stuart M. Phillips   +12 more
openalex   +2 more sources

A Novel 10‐Protein Score for Liver Fat Content Predicts Cardiovascular‐Kidney‐Metabolic Disease Risk

Advanced Science, EarlyView.
A novel 10‐protein plasma score precisely quantifies liver fat, outperforming the fatty liver index. It robustly predicts the risk of numerous cardiovascular‐kidney‐metabolic diseases and integrates with genetic data for precision prevention, offering a practical alternative to magnetic resonance imaging (MRI). Abstract Liver fat content (LFC) is a key
Xiaoqin Gan, Yuanxiu Wei, Yiting Wu, Xinyue Su, Gangling Wang, Sisi Yang, Ziliang Ye, Yanjun Zhang, Hao Xiang, Yu Huang, Yiwei Zhang, Yuanyuan Zhang, Xianhui Qin   +12 more
wiley   +1 more source

Proteome Birthdating: A Single-Sample Approach for Measuring Global Turnover Dynamics and “Protein Age”

Michael E. Meadow, Sarah Broas, Margaret Hoare, M.W. Ahmed, Fatemeh Alimohammadi, Kevin Welle, Kyle Swovick, Jennifer R. Hryhorenko, Ankur Jain, John C Martinez, Andrei Seluanov, Vera Gorbunova, Abigail Buchwalter, Sina Ghaemmaghami   +13 more
openalex   +1 more source

SynaptopathyDB integrates synaptic proteomes, genetic and phenotypic data to advance research on nervous system disorders. [PDF]

Sci Rep
Sorokina O, Dominic D, Bayés À, Armstrong JD, Grant SGN.   +4 more
europepmc   +1 more source