Results 261 to 270 of about 205,179 (309)

Proteome-Wide Identification and Comparison of Drug Pockets for Discovering New Drug Indications and Side Effects. [PDF]

Molecules
Zhang R, Chen Z, Li S, Lv H, Li J, Yang N, Dai S.   +6 more
europepmc   +1 more source

Cutting‐Edge Aptasensing Approaches for Electrochemical Detection of Exosomes Utilizing MXenes

ChemElectroChem, EarlyView.
This work notably summarizes research on 2D MXenes/MXene's‐hybrid‐based nanoplatforms patterned with aptamers as an alternative to antibodies affording highly sensitive and robust biosensing of exosomes as well as their efficient isolation. The exosomes are highlighted as a valuable source of biomarkers and with the immobilization approaches of ...
Andrej Vikartovský, Natália Košútová, Lenka Lorencová, Peter Kasák, Tomáš Bertók, Ján Tkáč   +5 more
wiley   +1 more source

The proteomic landscape of trophoblasts unravels calcium-dependent syncytialization processes and beta-chorionic gonadotropin (ß-hCG) production. [PDF]

Reprod Biol Endocrinol
Gehl AL, Klawitter D, Wissenbach U, Cole M, Wesely C, Löhr H, Weissgerber P, Sota A, Meyer MR, Fecher-Trost C.   +9 more
europepmc   +1 more source

Tryptophan‐Selective Chemical Modification of Peptides by Thioether‐Mediated Sulfenylation

ChemistryEurope, EarlyView.
A thioether‐mediated sulfenylation method based on 4‐fluorophenyl 3‐nitro‐2‐pyridinesulfenate (Npys‐OPh(pF)) is developed for Trp‐selective chemical modification. This sulfenylation proceeds under mild, metal‐free, and weakly acidic conditions and is broadly applicable to the chemical modification of various Trp‐containing peptides as well as the late ...
Hayate Shida, Akihiro Taguchi, Yuma Tokita, Yan Cui, Momoka Sakamaki, Sho Konno, Atsuhiko Taniguchi, Young Sook Yun, Yuuta Fujikawa, Hiroshi Kaneko, Hidemasa Nakaminami, Yoshio Hayashi   +11 more
wiley   +1 more source

Dexamethasone vs. placebo modulation of the perioperative blood immune proteome in patients undergoing total knee arthroplasty. [PDF]

BMC Anesthesiol
Mølgaard AK, Gasbjerg KS, Mathiesen O, Hägi-Pedersen D, Gögenur I.   +4 more
europepmc   +1 more source

In Vitro Psilocybin Synthesis by Co‐Immobilized Enzymes

Chemistry – A European Journal, Accepted Article.
Advanced clinical trials investigate the Psilocybe magic mushroom natural product psilocybin as a treatment against major depressive disorder. Currently, synthetic material is used to meet the demand for legitimate pharmaceutical purposes. Here, we report an in vitro approach to biocatalytically produce psilocybin on a solid‐phase matrix charged with ...
Tim Schäfer, Alexander Sherwood, Thomas Kirkland, Thomas Krüger, Jakob Worbs, Olaf Kniemeyer, Markus Gressler, Dirk Hoffmeister   +7 more
wiley   +1 more source

Plasma proteomics in pediatric patients with sepsis- hopes and challenges. [PDF]

Clin Proteomics
Fan S, Zeng S.
europepmc   +1 more source

The Heterotaxy Gene CCDC11 Is Important for Cytokinesis via RhoA Regulation

Cytoskeleton, EarlyView.
ABSTRACT Mutations in CCDC11 (cfap53) have been identified in multiple patients with heterotaxy (Htx), a disorder of left–right (LR) patterning of the internal organs. In Xenopus, depletion of Ccdc11 causes defects in LR patterning, recapitulating the patient phenotype. Upon Ccdc11 depletion, monociliated cells of the Left–Right Organizer (LRO) exhibit
Saurabh S. Kulkarni, Rachel E. Stephenson, Sarah Amalraj, Angelo Arrigo, Ewelina Betleja, James J. Moresco, John R. Yates III, Moe R. Mahjoub, Ann L. Miller, Mustafa K. Khokha   +9 more
wiley   +1 more source

Low-complexity regions in fungi display functional groups and are depleted in positively charged amino acids. [PDF]

NAR Genom Bioinform
Steczkiewicz K, Kossakowski A, Janik S, Muszewska A.   +3 more
europepmc   +1 more source

SEC‐SAXS/MC Ensemble Structural Studies of the Microtubule Binding Protein Cdt1 Show Monomeric, Folded‐Over Conformations

Cytoskeleton, EarlyView.
ABSTRACT Cdt1 is a mixed folded protein critical for DNA replication licensing and it also has a “moonlighting” role at the kinetochore via direct binding to microtubules and the Ndc80 complex. However, it is unknown how the structure and conformations of Cdt1 could allow it to participate in these multiple, unique sets of protein complexes.
Kyle P. Smith, Srinivas Chakravarthy, Amit Rahi, Manas Chakraborty, Kristen M. Vosberg, Marco Tonelli, Maximilian G. Plach, Arabela A. Grigorescu, Joseph E. Curtis, Dileep Varma   +9 more
wiley   +1 more source