Results 291 to 300 of about 461,354 (348)

Protein turnover downstream of the Nipbl/CRL4 axis contributes to abnormal development in zebrafish embryos

Developmental Dynamics, EarlyView.
Abstract Background Mutations in cohesins cause cohesinopathies such as Cornelia de Lange Syndrome (CdLS) and Roberts Syndrome (RBS). Prior findings demonstrate that Esco2 (a cohesin activator) and Smc3 (a core cohesin subunit) regulate the CRL4 E3 ubiquitin ligase. SMC3 mutations, however, account for a small percentage of CdLS.
Annie C. Sanchez, Niusha Banoukh, Fiona Mensching, Robert V. Skibbens, M. Kathryn Iovine   +4 more
wiley   +1 more source

Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues

ESC Heart Failure, Volume 12, Issue 2, Page 1059-1080, April 2025.
Abstract Systemic aging influences various physiological processes and contributes to structural and functional decline in cardiac tissue. These alterations include an increased incidence of left ventricular hypertrophy, a decline in left ventricular diastolic function, left atrial dilation, atrial fibrillation, myocardial fibrosis and cardiac ...
Zhuyubing Fang, Umar Raza, Jia Song, Junyan Lu, Shun Yao, Xiaohong Liu, Wei Zhang, Shujuan Li   +7 more
wiley   +1 more source

Remodeling of the neutrophil proteome upon exposure to <i>Pseudomonas aeruginosa</i> biofilms. [PDF]

Microbiol Resour Announc
Rizakos T, Geddes-McAlister J.
europepmc   +1 more source

GEO combined with quantitative protein trait loci identify causative proteins in hypertrophic cardiomyopathy

ESC Heart Failure, EarlyView.
Abstract Aims Hypertrophic cardiomyopathy (HCM) is a rare genetic heart disease characterized by a limited patient population and scarce research and treatment resources. This study aimed to identify HCM‐associated proteins by integrating cardiac tissue data from the Gene Expression Omnibus (GEO) database with the latest protein quantitative trait ...
Bo Li, Xu Zhao, Yan Ding, Yi Zhang
wiley   +1 more source

Carbon upshift in <i>Lactococcus cremoris</i> elicits immediate initiation of proteome-wide adaptation, coinciding with growth acceleration and pyruvate dissipation switching. [PDF]

mBio
van Olst B, Boeren S, Vervoort J, Kleerebezem M.   +3 more
europepmc   +1 more source

Identification of serum C4BPA as a potential diagnostic marker of right ventricular remodelling via proteomic analysis

ESC Heart Failure, EarlyView.
Abstract Aims Right ventricular (RV) remodelling, a progressive condition characterized by maladaptive cardiac structural and functional changes, primarily results from prolonged pressure overload in patients with pulmonary hypertension (PH). Accurate, universal and easy‐to‐use biomarkers for assessing the severity of RV remodelling are lacking.
Xuenan Wang, Cheng Yu, Meiling Li, Huiling Cai, Yongjian Yang, Cong Lan   +5 more
wiley   +1 more source

ProSIMSIt: The Best of Both Worlds in Data-Driven Rescoring and Identification Transfer. [PDF]

J Proteome Res
Hamood F, Gabriel W, Pfeiffer P, Kuster B, Wilhelm M, The M.   +5 more
europepmc   +1 more source

Microvascular obstruction in cardiac amyloidosis

European Journal of Heart Failure, EarlyView.
Abstract Aims Cardiac amyloidosis (CA) is characterized by deposition of amyloid fibrils within the extracellular space, causing disarray of the myocardial structure and capillary architecture. This study aims to characterize the prevalence of microvascular obstruction (MVO) in patients with CA and to assess the association between MVO and prognosis ...
Lucrezia Netti, Adam Ioannou, Ana Martinez‐Naharro, Yousuf Razvi, Aldostefano Porcari, Lucia Venneri, Viviana Maestrini, Dan Knight, Ruta Virsinskaite, Muhammad U. Rauf, Tushar Kotecha, Rishi K. Patel, Ashutosh Wechelakar, Helen Lachmann, Peter Kellman, Charlotte Manisty, James Moon, Philip N. Hawkins, Julian D. Gillmore, Marianna Fontana   +19 more
wiley   +1 more source

Corrigendum: A proteome-level investigation into <i>Plasmodiophora brassicae</i> resistance in <i>Brassica napus</i> canola. [PDF]

Front Plant Sci
Adhikary D, Mehta D, Uhrig RG, Rahman H, Kav NNV.   +4 more
europepmc   +1 more source

Proteomic biomarkers and pathway analysis for progression to heart failure in three epidemiological representative cohorts

European Journal of Heart Failure, EarlyView.
Markers of progression to heart failure (HF). Gal‐4, galectin‐4; GDF‐15, growth differentiation factor 15; NT‐proBNP, N‐terminal pro‐B‐type natriuretic peptide; ST2, suppression of tumorigenicity‐2. ABSTRACT Aims Biomarkers associated with asymptomatic ventricular dysfunction might improve risk stratification and identify pathways leading to heart ...
Anna Dieden, Nicolas Girerd, Filip Ottosson, John Molvin, Manan Pareek, Olle Melander, Erasmus Bachus, Lennart Råstam, Ulf Lindblad, Bledar Daka, Margrét Leósdóttir, Peter M. Nilsson, Michael H. Olsen, Andrew L. Clark, John G.F. Cleland, Christian Delles, Arantxa González, Zohra Lamiral, Kevin Duarte, Patrick Rossignol, Faiez Zannad, Petri Gudmundsson, Amra Jujić, Martin Magnusson   +23 more
wiley   +1 more source