Results 121 to 130 of about 599,323 (353)

Integrated Proteomics and Metabolomics Analysis in Pregnant Rat Mammary Glands after Circadian Rhythm Inversion

, 2023
Xinyue Sun, Jingjing Lin, Xiaofeng Dai, Jingping Yang, Qirong Zheng, Qiaosong Wang, Xueling Zhang, Yuanyuan He, Liping Kang, Rongjin Lin   +9 more
openalex   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

A Proteomic Approach Identified TFEB as a Key Player in the Protective Action of Novel CB2R Bitopic Ligand FD22a against the Deleterious Effects Induced by β-Amyloid in Glial Cells

Cells
Neurodegenerative diseases (NDDs) are progressive multifactorial disorders of the nervous system sharing common pathogenic features, including intracellular misfolded protein aggregation, mitochondrial deficit, and inflammation. Taking into consideration
Beatrice Polini, Lorenzo Zallocco, Francesca Gado, Rebecca Ferrisi, Caterina Ricardi, Mariachiara Zuccarini, Vittoria Carnicelli, Clementina Manera, Maurizio Ronci, Antonio Lucacchini, Riccardo Zucchi, Laura Giusti, Grazia Chiellini   +12 more
doaj   +1 more source

Peer Review #3 of "Identification of potential glioma drug resistance target proteins based on ultra-performance liquid chromatography-mass spectrometry differential proteomics (v0.1)"

, 2023

openalex   +1 more source

Quantitative proteomic analysis reveals different characteristics of bladder cancer cells after exposure to bisphenol A

FEBS Open Bio, EarlyView.
Bisphenol A (BPA), a common chemical in plastics, exerts dual effects on bladder cancer cells: low doses promote growth and migration, while high doses suppress growth and migration. Multi‐omics and bioinformatics reveal BPA acts via MAPK and inflammatory pathways.
Shaomin Niu, Lanlan Li, Wenjuan Jia, Hanzhong Feng, Xiaoquan Yu, Youli Zhao, Fengzhi Yuan, Hui Ding, Junqiang Tian, Yong‐Xing He, Zhiping Wang   +10 more
wiley   +1 more source

Comparative Analysis of Angora Rabbit Colostrum and Mature Milk Using Quantitative Proteomics

Biology
Colostrum intake is a crucial determinant of survival in newborn rabbits. Neonates rely entirely on passive immunity transfer from their mothers while suckling colostrum. The goal of this study was to explore the protein differences of rabbit milk during
Dongwei Huang, Yuanlang Wang, Haisheng Ding, Huiling Zhao   +3 more
doaj   +1 more source

Reprograming of gut microbiome energy metabolism by the FUT2 Crohn's disease risk polymorphism. [PDF]

, 2014
Fucosyltransferase 2 (FUT2) is an enzyme that is responsible for the synthesis of the H antigen in body fluids and on the intestinal mucosa. The H antigen is an oligosaccharide moiety that acts as both an attachment site and carbon source for intestinal ...
Borneman, James, Braun, Jonathan, Fornace, Albert J, Goudarzi, Maryam, Graeber, Thomas G, Haritunians, Talin, Huttenhower, Curtis, Kashyap, Purna C, Li, Xiaoxiao, McGovern, Dermot PB, McHardy, Ian, Ruegger, Paul, Schwager, Emma, Sonnenburg, Justin L, Tong, Maomeng   +14 more
core  

Contents: Proteomics 18'19 [PDF]

, 2019
Melissa Pergande, Fidel Serna-Perez, Banu Mohsin, Jonathon Hanek, Stephanie Cologna, Jace Jones, Chinmoy Sarkar, Marta Lipinski, Maureen Kane, Viktor Brovkovych, Alyssa Aldrich, Nasi Li, G Ekin, Jonna Frasor, Giovanni Forcina, Scott Dixon, Carlos Bozelli, Richard Epand   +17 more
openalex   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Molecular Effects of Inorganic and Methyl Mercury in Aquatic Primary Producers: Comparing Impact to A Macrophyte and A Green Microalga in Controlled Conditions

Geosciences, 2018
Mercury (Hg) remains hazardous in aquatic environments, because of its toxicity and high biomagnification in food webs. In phytoplankton and macrophytes, Hg compounds at high concentration have been reported to affect the growth, photosynthesis, and ...
Rebecca Beauvais-Flück, Vera I. Slaveykova, Claudia Cosio   +2 more
doaj   +1 more source