Results 111 to 120 of about 591,485 (302)

Quantitative proteomic (iTRAQ) analysis of 1st trimester maternal plasma samples in pregnancies at risk for preeclampsia [PDF]

, 2012
A current major obstacle is that no reliable screening markers exist to detect pregnancies at risk for preeclampsia. Quantitative proteomic analysis employing isobaric labelling (iTRAQ) has been suggested to be suitable for the detection of potential ...
Hoesli, I., Hahn, S., Jeno, P., Kolla, V., Moes, S., Lapaire, O.   +5 more
core   +1 more source

Spatially resolved proteomic mapping in living cells with the engineered peroxidase APEX2

Nature Protocols, 2016
In this protocol, Hung et al. describe a method for performing cell compartment–specific proteomics for regions of interest using the engineered ascorbate peroxidase APEX2.
Victoria Hung, N. Udeshi, Stephanie S. Lam, Ken H. Loh, Kurt J. Cox, Kayvon Pedram, S. Carr, Alice Y. Ting   +7 more
semanticscholar   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Proteomic insights into parasite biology [PDF]

, 2012
McKean, P.G., Burchmore, R.J.S., McKean, Paul G., Grant, Karen M., Grant, K.M., Burchmore, Richard, Ginger, M.L., Ginger, Michael L.   +7 more
core   +6 more sources

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Proteomic analysis of porcine bone-conditioned medium. [PDF]

, 2014
PURPOSE Autografts are considered to support bone regeneration. Paracrine factors released from cortical bone might contribute to the overall process of graft consolidation.
Gruber, Reinhard, Buser, Daniel, Bosshardt, Dieter, Caballé-Serrano, Jordi   +3 more
core   +2 more sources

OSI-027 as a Potential Drug Candidate Targeting Upregulated Hub Protein TAF1 in Potential Mechanism of Sinonasal Squamous Cell Carcinoma: Insights from Proteomics and Molecular Docking

Biology
Sinonasal squamous cell carcinoma (SNSCC) is a rare tumor with high mortality and recurrence rates. However, SNSCC carcinogenesis mechanisms and potential therapeutic drugs have not been fully elucidated.
Watcharapong Panthong, Chamsai Pientong, Thawaree Nukpook, Chukkris Heawchaiyaphum, Sirinart Aromseree, Tipaya Ekalaksananan   +5 more
doaj   +1 more source

Proteomic analysis of unbounded cellular compartments: synaptic clefts

Cell, 2016
SUMMARY Cellular compartments that cannot be biochemically isolated are challenging to characterize. Here we demonstrate the proteomic characterization of the synaptic clefts that exist at both excitatory and inhibitory synapses.
Ken H. Loh, Philipp S. Stawski, Austin S Draycott, N. Udeshi, Emily K. Lehrman, D. Wilton, Tanya Svinkina, T. Deerinck, Mark Ellisman, B. Stevens, S. Carr, Alice Y. Ting   +11 more
semanticscholar   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source