Results 141 to 150 of about 599,323 (353)

Multi-omics profiling reveals peripheral blood biomarkers of multiple sclerosis: implications for diagnosis and stratification

Frontiers in Pharmacology
BackgroundMultiple sclerosis (MS), a chronic autoimmune disorder marked by demyelination in the central nervous system, is exceptionally uncommon in China, and remains poorly understood in terms of its peripheral blood manifestations.MethodsWe conducted ...
Qinming Zhou, Qinming Zhou, Qinming Zhou, Zuoquan Xie, Lu He, Lu He, Guangqiang Sun, Huanyu Meng, Huanyu Meng, Zhiyu Luo, Yuan Feng, Xingkun Chu, Liang Li, Jing Zhang, Yong Hao, Meiyu Geng, Meiyu Geng, Xiang Zhang, Xiang Zhang, Sheng Chen, Sheng Chen, Sheng Chen   +21 more
doaj   +1 more source

Advances in Proteomics and Bioinformatics

, 2020

openalex   +1 more source

Supplementary Data for Stabilizing the Proteomes of Acute Myeloid Leukemia Cells: Implications for Cancer Proteomics

, 2023
James P. Malone, Robert W. Sprung, Qiang Zhang, Michael H. Kramer, Matthew Christopher, Petra Erdmann-Gilmore, Yiling Mi, Timothy J. Ley, Reid Townsend   +8 more
openalex   +1 more source

Proteomics [PDF]

Nature Biotechnology, 2019
openaire   +2 more sources

Fluid Biomarkers of Disease Burden and Cognitive Dysfunction in Progressive Supranuclear Palsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Identifying objective biomarkers for progressive supranuclear palsy (PSP) is crucial to improving diagnosis and establishing clinical trial and treatment endpoints. This study evaluated fluid biomarkers in PSP versus controls and their associations with regional 18F‐PI‐2620 tau‐PET, clinical, and cognitive outcomes.
Roxane Dilcher, Charles B. Malpas, Stuart J. McDonald, William T. O’Brien, Craig Despott, Kelly L. Bertram, Matthew P. Pase, Lukas Frontzkowski, Meng Law, Terence J. O’Brien, Lucy Vivash   +10 more
wiley   +1 more source

Rapid pre-gel visualization of proteins with mass spectrometry compatibility [PDF]

, 2010
Despite all of the prophecies of doom, gel electrophoresis is still prevalent in modern proteomic workflows. However, the currently used protein staining methods represent a serious bottleneck for a quick subsequent protein analysis using mass ...
Marco A. Mata-Gomez, Matthew T. Yasui, Robert Winkler   +2 more
core   +1 more source

Ketogenic Diet as an Epigenetic Therapy in SETD1B‐Related Epilepsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Histone lysine methyltransferases such as SETD1B regulate chromatin structure and gene transcription. Ketone bodies, including butyrate, act as histone deacetylase inhibitors. We report a 4‐year‐old boy with SETD1B‐related absence epilepsy, refractory to conventional medications, who achieved sustained > 90% seizure reduction on the Modified ...
Erica Tsang, Brian S. Gloss, Jessica P. Hayes, Andrew J. A. Holland, Manoj P. Menezes, Joceline A. Branson, Shekeeb S. Mohammad, Jingya J. Yan, Shrujna Patel, Velda X. Han, Russell C. Dale   +10 more
wiley   +1 more source

Integrating proteomics and explainable artificial intelligence: a comprehensive analysis of protein biomarkers for endometrial cancer diagnosis and prognosis

Frontiers in Molecular Biosciences
Endometrial cancer, which is the most common gynaecological cancer in women after breast, colorectal and lung cancer, can be diagnosed at an early stage.
Seyma Yasar, Fatma Hilal Yagin, Rauf Melekoglu, Luca Paolo Ardigò   +3 more
doaj   +1 more source

Contents – Proteomics 13'2009 [PDF]

, 2009
Maria Pernemalm, Luigi De Petris, Hanna Eriksson, Eva Brande, Hirsh Koyi, Lena Kanter, Rolf Lewensohn, Janne Lehtio, Ping Ninglingwang, Xuejiang Zhang, Jin Guo, Ran Xie, Huo, Lin Fuqiangwang, Jian Chen, Zuomin Shen, Qinghua Zhou, Baige Shi, Jiahao Zhao, Sha, Alina Zamfir, Corina Flangea, Eugen Sisu, Alina Serb, Nicolae Dinca, Peter Bruckner, Daniela Seidler, Shin-Yiyu Zhangungyang, Kay-Hooi Khoo, Albert Wu, Rene Zahedi, Christianvo Lzing, Andreas Schmitt, Michael Frien, Martin Jung, Johanna Dudek, Albert Stefaniewortelkamp, Richard Sickmann, Zimmermann, Juan Bustamante, Leticia Gonzalez, Christophera Carroll, Susant Weintraub, Roberto Aguilar, Jesus Mun Oz, Andrew Martinez, Luis Haro   +46 more
openalex   +1 more source

RNA Sequencing Resolves Cryptic Pathogenic Variants in Mitochondrial Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Mitochondrial diseases are the most common inherited metabolic disorders, characterized by pronounced clinical and genetic heterogeneity that complicates molecular diagnosis. Although DNA‐based sequencing approaches have become standard in genetic testing, up to half of patients remain without a definitive diagnosis.
Zhimei Liu, Xin Duan, Fatemeh Peymani, Jia Wang, Chengjia Bao, Chaolong Xu, Ying Zou, Zixuan Zhang, Yunxi Zhang, Tongyue Li, Martin Pavlov, Junling Wang, Minhan Song, Tianyu Song, Xiaodi Han, Mingxi Sun, Danmin Shen, Ruoyu Duan, Huafang Jiang, Manting Xu, Holger Prokisch, Fang Fang   +21 more
wiley   +1 more source